Priming immunity via herbal components and their nanomedicines for the treatment of cancer  

作　　者：Xiang Li Chenkai Gong Abid Naeem Jing Liu Ming Yang Jing Zhang Hongming Shang 

机构地区：[1]National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine,State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine,Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Chinese Medicine,Nanchang,China [2]China Resources Jiangzhong Pharmaceutical Group Co.,Ltd.,Nanchang,China [3]School of Life Science,Advanced Research Institute of Multidisciplinary Science,School of Medical Technology,Key Laboratory of Molecular Medicine and Biotherapy,Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering,Beijing Institute of Technology,Beijing,China [4]Department of Biochemistry&Chemical Biology,Vanderbilt University,Nashville,TN,USA

出　　处：《Acupuncture and Herbal Medicine》2024年第4期436-462,共27页针灸和草药(英文)

基　　金：the National Natural Science Foundation of China(82260695,82360781);the Jiangxi Provincial Natural Science Foundation(20232ACB206062);Jiangxi Provincial Department of Education(GJJ2400823);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202207);Young Jinggang Scholar of Jiangxi Province(Jing Zhang)and New Century Talents Project of Jiangxi Province(2017082,Xiang Li and 2020028,Jing Zhang);the Science and Technology Innovation Team of Jiangxi University of Chinese Medicine(CXTD22001 and CXTD22006);Jiangxi University of Traditional Chinese Medicine Special Zone Construction Project of Traditional Chinese Medicine(New Drug Creation Direction)(TQ-20).

摘　　要：Recently,immunotherapy has redefined cancer treatment by promoting the rapid killing of tumor cells through the immune system.Herbal medicines have been increasingly used as adjunct therapies to complement cancer treatment along with chemotherapy and radiotherapy to delay tumor development,reduce pain,and prolong patient survival.However,the potential immunotherapeutic effects of these herbal derivatives are limited by their structural instability,poor membrane permeability,and low bioavailability.To address this issue,nanotechnology has been used to enhance the activity of active compounds.Therefore,this review focuses on the effectiveness of the active ingredients of herbal medicines in suppressing tumor progression by modulating both the innate and adaptive immune systems,challenges in their delivery,and the application of nanocarriers for the effective delivery of these herbal components.

关 键 词：ANTI-TUMOR Herbal components Immune system Nanodrug delivery systems 

分 类 号：R73[医药卫生—肿瘤]