Recent advances in the bench-to-bedside translation of cancer nanomedicines  

作　　者：Yang Liu Yinchao Zhang Huikai Li Tony Y.Hu 

机构地区：[1]Department of Hepatobiliary Cancer,Liver Cancer Center,Tianjin Medical University Cancer Institute&Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin’s Clinical Research Center for Cancer,Tianjin 300060,China [2]Department of Hepatobiliary and Pancreatic Oncology,Tianjin Cancer Hospital Airport Hospital,National Clinical Research Center for Cancer,Tianjin 300308,China [3]Department of Biochemistry and Molecular Biology,Tulane University School of Medicine,New Orleans,LA 70112,USA

出　　处：《Acta Pharmaceutica Sinica B》2025年第1期97-122,共26页药学学报(英文版)

基　　金：supported by the National Natural Science Foundation of China(No.82202603);the Scientific Research Plan Project initiated by the Tianjin Municipal Education Commission(No.2022ZD066,China);the Science and Technology Project of Tianjin Municipal Health Commission(No.TJWJ2021QN008,China).

摘　　要：Cancer remains a complex and challenging medical problem,driving extensive research efforts.Despite significant progress in understanding its genetic and molecular aspects,the quest for effective treatments continues.Nanomedicines have shown great potential for revolutionizing cancer treatment by offering targeted and controlled drug delivery,reducing side effects,and improving patient outcomes.Accordingly,nanomedicines have been the focus of extensive research and development for clinical translation.As of September 2024,a search on the ClinicalTrials.gov website using the term“nanoparticles”revealed numerous ongoing and planned clinical trials.Motivated by recent advances in the field,this review explores the current frontier of cancer nanomedicine.Nanomedicines have supported chemotherapy,phototherapy and sonodynamic therapy,nucleic acid therapy,and immunotherapy.However,translating nanomedicines into practice has been challenged by complex interactions between nanoparticles and biological systems,variable permeability and retention of nanoparticles in tumors,safety concerns,difficulty achieving targeted delivery,and issues with scaling up manufacturing.Perspectives on addressing these challenges are offered.Future opportunities for cancer nanomedicines,including modifying the tumor microenvironment,integrating artificial intelligence and big data,and targeting new medical areas,are also discussed.This review underscores the potential of cancer nanomedicines to revolutionize treatment from a clinical standpoint.

关 键 词：Cancer nanomedicines Clinical translation Clinical trial landscape ANTICANCER Tumor microenvironment Combination therapies Clinical nanotechnology Drug delivery systems 

分 类 号：R73[医药卫生—肿瘤]