Emerging non-antibody‒drug conjugates (non-ADCs) therapeutics of toxins for cancer treatment  

作　　者：Xiaolan Xu Jiaming Zhang Tao Wang Jing Li Yukang Rong Yanfang Wang Chenxia Bai Qing Yan Xiaohua Ran Yingli Wang Tianhong Zhang Jin Sun Qikun Jiang 

机构地区：[1]Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang 110016,China [2]School of Education,University of Nottingham,Nottingham NG72RD,UK [3]Department of Pharmacy,Linyi People's Hospital,Shandong University,Linyi 276000,China [4]State Key Laboratory of Natural and Biomimetic Drugs,Peking University,Beijing 100871,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第4期1542-1559,共18页药学学报（英文版）

基　　金：This work was supported by the National Postdoctoral Foundation of China(No.2023M730375);Liaoning Province Department of Education Project(No.LJKMZ20221365,China);the State Key Laboratory of Natural and Biomimetic Drugs(No.K202215,China);the National Natural Science Foundation of China(No.82173766);Liaoning Province Applied Basic Research Program(No.2022JH2/101300097,China);the Natural Science Foundation of Shandong Province(No.ZR2021QH084,China)。

摘　　要：The non-selective cytotoxicity of toxins limits the clinical relevance of the toxins.In recent years,toxins have been widely used as warheads for antibody-drug conjugates(ADCs)due to their eff-cient killing activity against various cancer cells.Although ADCs confer certain targeting properties to the toxins,low drug loading capacity,possible immunogenicity,and other drawbacks also limit the po-tential application of ADCs.Recently,non-ADC delivery strategies for toxins have been extensively investigated.To further understand the application of toxins in anti-tumor,this paper provided an over-view of prodrugs,nanodrug delivery systems,and biomimetic drug delivery systems.In addition,toxins and their combination strategies with other therapies were discussed.Finally,the prospect and challenge of toxins in cancertreatmentwerealso summarized.

关 键 词：TOXINS Non-antibody-drug conjugates Delivery strategies PRODRUGS Nano drug delivery systems Biomimetic drugdelivery systems Combination strategies Cancer treatment 

分 类 号：R285[医药卫生—中药学]