云南高校图书馆联盟文献共享服务平台- CHEMOENZYMATIC

CHEMOENZYMATIC: 作品数：20被引量：19H指数：2; 导出分析报告; 相关领域：理学医药卫生更多>>; 相关作者：易文更多>>; 相关机构：浙江大学山东大学更多>>; 相关期刊：《Chemical Research in Chinese Universities》《中国生物学文摘》《Chinese Journal of Chemical Engineering》《Engineering Microbiology》更多>>; 相关基金：国家自然科学基金中国博士后科学基金更多>>

Chemoenzymatic Synthesis of Common Legionaminic Acid−Containing Pentasaccharide of Capsular Polysaccharides from Acinetobacter baumannii K27 and K44: 《Chinese Journal of Chemistry》2025年第1期33-38,共6页Jiarong Peng Tianhui Hao Wenjing Ma Zhuojia Xu Tiehai Li; financially supported by the National Natural Science Foundation of China(22077130 and 22377134);Shanghai Municipal Science and Technology Major Project.; Acinetobacter baumannii infections pose a great threat to public health owing to upsurging antibiotic resistance.Capsular polysaccharides(CPS)are major virulence determinants of pathogenic bacteria and have attracted ...; 关键词：Acinetobacterbaumanni Capsular polysaccharide Legionaminic acid Bacterial oligosaccharide Chemoenzymatic synthesisl Stereoselectiveglycosylation Enzyme-catalyzed synthesis Synthesis design

A chemoenzymatic cascade for sustainable production of chiral N-arylated aspartic acids from furfural and waste: 《Chinese Journal of Catalysis》2024年第12期102-111,共10页Guang-Hui Lu Jian Yu Ning Li; 国家重点研发计划(2021YFC_(2)102700);国家自然科学基金(21971076).; Both biomass valorization and waste upcycling are important routes to sustain the circular bioeconomy.In this work,we present a chemoenzymatic cascade for selective synthesis of chiral N-arylated aspartic acids from b...; 关键词：Asymmetric synthesis Biomass conversion Continuous flow photocatalysis Paired electrosynthesis Waste upcycling

Chemoenzymatic Synthesis of N,N,N-Trimethyl-D-Glucosamine Chitotriomycin and Its Analogues: 《Chinese Journal of Chemistry》2024年第19期2293-2298,共6页Jianghua Li Yan Zhang Zhifei Hu Jinfeng Ye Hongzhi Cao; supported by the National Key Research and Development Program of China(2021YFC2101500);the National Natural Science Foundation of China(22277111 and 22107094);Taishan Scholar Project(TSTP20221114);Department of Science and Technology of Shandong Province(2020CXGC010601,ZR2023ZD45,and ZR2021QB061).; Comprehensive Summary,N,N,N-Trimethyl-D-glucosamine(TMG)-chitotriomycin,a naturally occurring chitin related oligosaccharide,is a specificβ-N-acetylhexosaminidases(HexNAcases)inhibitor for insects and fungi.Although ...; 关键词：Carbohydrates GLYCOSYLATION Chitosan OLIGOSACCHARIDES BIOCATALYSIS

Practical Synthesis of Valbenazine via 1,3-Dipolar Cycloaddition: 《Chinese Journal of Chemistry》2024年第8期841-845,共5页Yalan Peng Zuming Lin Lili Zhu Shiqing Han Sha-Hua Huang Ran Hong; the National Natural Science Foundation of China(22271194 and 22371295);the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture(Grant No.XTD 2210);the Science and Technology Commission of Shanghai Municipality(20XD1404700)is greatly appreciated.; Comprehensive Summary,Valbenazine(Ingrezza),a potent and highly selective inhibitor of vesicular monoamine transporter type 2(VMAT2)through the active metabolite hydrotetrabenazine(HTBZ),has been approved for the trea...; 关键词：CYCLOADDITION CHEMOENZYMATIC Kinetic resolution PRODRUGS VMAT2 inhibitor

Breakthrough in the challenging P450-catalyzed chemoenzymatic synthesis of C14-functionalized steroids: 《Science China Chemistry》2023年第9期2435-2436,共2页Manfred T.Reetz Frank Hollmann; Intensive past research has demonstrated that cytochrome P450 monooxygenases are involved in the biosynthesis of numerous natural products and in human metabolism of various pharmaceuticals [1]. This inspired syntheti...; 关键词：STEROIDS CATALYZED synthesis

Exploiting Complex-Type N-Glycan to Improve the in Vivo Stability of Bioactive Peptides被引量：1: 《CCS Chemistry》2023年第7期1623-1634,共12页Qijia Wei Jun Zhang Yuankun Dao Mengliang Ye Dangliang Liu Weidong Dong Ning Yuan Hongxing Li Chunli Song Mo Li Xiaomeng Shi Suwei Dong; This research was made possible as a result of a generous grant from the Beijing National Science Foundation(grant no.JQ18024);the National Key R&D Program of China(grant no.2018YFA0507602);the National Natural Science Foundation of China(grant nos.91953111 and 91853113).; Peptides can be potentmolecules with high efficacy and selectivity in the development of biotherapeutics.However,the poor pharmacokinetic properties of peptides pose major challenges for their broader medicinal applic...; 关键词：therapeutic peptides STABILITY Nglycosylation solid-phase peptide synthesis chemoenzymatic approach hydrogen-deuterium exchange mass spectrometry

Divergent Synthesis of Core m1,Core m2 and Core m3 O-Mannosyi Glycopeptides via a Chemoenzymatic Approach: 《Chinese Journal of Chemistry》2022年第13期1571-1577,I0002,共8页Tianlu Li Youqin Zhang Tong Li Haoru Zhuang Fengshan Wang Ning Wang Richard R.Schmidt Peng Peng; This work is financially supported by the National Natural Science Foundation of China(Grant Nos.22177061,92053110,21977063,21907056);the China Postdoctoral Science Foundation(2020M680090);the Shenzhen Science and Technology Program(RCBS20200714114957255);the Open Projects Fund of Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology(2021CCG01&02);the Central Government Guide Local Science and Technology Development Funds(YDZX20203700002579).; O-Mannosylation plays a vital role in the regulation of a variety range of biological processes,for instance,brain and muscle development.However,the precise function remains largely unknown due to its innate heteroge...; 关键词：GLYCOPEPTIDES OLIGOSACCHARIDES Regioselectivity Enzyme catalysis Divergent synthesis

A chemoenzymatic cascade with the potential to feed the world and allow humans to live in space: 《Engineering Microbiology》2022年第1期39-41,共3页Shuke Wu Uwe T.Bornscheuer; Huazhong Agricultural University for a startup grant and a grant from the Fundamental Research Funds for the Central Uni-versities(Project No.2662021JC006).; While the typical targets of(chemo-)enzymatic cascades are fine chemicals(e.g.,pharmaceuticals),a chemoen-zymatic cascade,artificial starch anabolic pathway(ASAP),was recently developed to synthesize starch from CO_(2...; 关键词：Chemoenzymatic cascade Cell-free system Carbon dioxide Artificial pathway

Chemical and chemoenzymatic stereoselectivesynthesis of β-nucleosides and their analogues被引量：1: 《Organic Chemistry Frontiers》2022年第6期1719-1741,共23页Hui-Jing Wang Yang-Yang Zhong You-Cai Xiao Fen-Er Chen; support from the Fundamental Research Funds for the Central Universities(Grants YJ201853,YJ201805 and YJ202120);the National Natural Science Foundation(Grant 21907072).; β-Nucleosides are fundamental building blocks of biological systems and are widely used as therapeuticagents for the treatment of cancer and viral infections, among others. In the last two years, nucleosideanalogues ...; 关键词：synthesis ANALOGUES NUCLEOSIDE

Recent advance of chemoenzymatic catalysis for the synthesis of chemicals: Scope and challenge被引量：2: 《Chinese Journal of Chemical Engineering》2021年第2期146-167,共22页Mengjiao Xu Zhuotao Tan Chenjie Zhu Wei Zhuang Hanjie Ying Pingkai Ouyang; The authors thank the financial support by National Natural Science Foundation of China(21776132,21878142);Jiangsu Province Natural Science Foundation for Distinguished Young Scholars(BK20190035);National Key Research and Development Program of China(2019YFD1101202);Jiangsu Province Natural Science Foundation for Youths(BK20200685);China Postdoctoral Science Foundation(2019M660113).; Chemoenzymatic catalysis can give full play to the advantages of versatile reactivity of chemocatalysis and excellent chemo-,regio-,and stereoselectivities of biocatalysis.These chemoenzymatic methods can not only sav...; 关键词：CHEMOENZYMATIC Dynamic kinetic resolution Cofactor regeneration BIOCATALYSIS Chemocatalysis

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