云南高校图书馆联盟文献共享服务平台- NUCLEOSIDE

NUCLEOSIDE: 作品数：132被引量：329H指数：9; 导出分析报告; 相关领域：医药卫生理学更多>>; 相关作者：张礼和张亮仁杨振军张衡展鹏更多>>; 相关机构：北京大学中国药科大学山东大学澳门大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划河南省自然科学基金更多>>

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord: 《Neural Regeneration Research》2025年第8期2311-2312,共2页Krisztián Pajer Tamás Bellák Antal Nógrádi; Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular factors.Although the spinal cord ...; 关键词：INJURED capacity MODIFIED

Amoenucles A-F,novel nucleoside derivatives with TNF-α inhibitory activities from Aspergillus amoenus TJ507: 《Chinese Journal of Natural Medicines》2025年第1期111-118,共8页Yeting Zhang Zhengyi Shi Chunhua Zhao Lanqin Li Ming Chen Yunfang Cao Fengqing Wang Bo Tao Xinye Huang Jieru Guo Changxing Qi Weiguang Sun Yonghui Zhang; supported by the National Natural Science Foundation for Distinguished Young Scholars (No. 81725021);the National Natural Science Foundation of China (Nos.82003633 and 82173705)。; Amoenucles A-F(1-6),six previously undescribed nucleoside derivatives,and two known analogs(7 and 8)were isolated from the culture of Aspergillus amoenus TJ507.Their structures were elucidated through spectroscopic an...; 关键词：Aspergillus amoenus TJ507 Nucleoside derivatives Intramolecular transesterification Tumor necrosis factorα(TNF-α)

Influence of nonalcoholic fatty liver disease on the therapeutic effect of nucleoside(acid)analogs for hepatitis B virus: 《World Journal of Hepatology》2024年第12期1395-1406,共12页Hua-Dong Li Ya-Nan Liu Shuang Wu Xu-Feng Quan Xiao-Yan Wang Tian-Dan Xiang Shu-Meng Li Ling Xu Tong Wang Hua Wang Xin Zheng; Supported by National Science and Technology Major Project of China,No.92169121;National Key R and D Projects,No.2022YFC2305100;Wuhan Science and Technology Bureau Knowledge Innovation Special Foundation of Hubei Province,No.2022020801010588.; BACKGROUND The effect of nonalcoholic fatty liver disease(NAFLD)on the efficacy of nucleoside analogues(NAs)in antiviral therapy for patients with chronic hepatitis B(CHB)remains controversial.AIM To investigate the i...; 关键词：Nonalcoholic fatty liver disease Chronic hepatitis B Nucleoside analogues Antiviral therapy Virological response

2′-Fluorinated nucleoside chemistry for new drug discovery:achievements and prospects: 《National Science Review》2024年第10期362-379,共18页Yonggang Meng Nannan Sun Lan Liang Bin Yu Junbiao Chang; supported by the National Natural Science Foundation of China(82130103,U1804283,81773570,22277110,82204209,and 82473761);the National Key R&D Program of China(2021YFC0864700 and 2022YFE0202700);the Central Plains Scholars and Scientists Studio Fund(2018002);China Postdoctoral Science Foundation(2023T160601);Henan Province Epidemic Prevention and Control Emergency Research Project(221111311400).; Fluorinated nucleosides are an important class of modified nucleosides that have demonstrated therapeutic potential for treating various human diseases,especially viral infections and cancer.Many fluorinated nucleosid...; 关键词：fluorinated nucleosides antitumor activity antiviral activity drug discovery

Clinical outcomes of cessation of nucleoside/nucleotide analogues in Chinese patients with HBeAg-negative chronic hepatitis B: 《iLIVER》2024年第2期22-27,共6页Fengyi Li Yadong Zhang Chao Liu Juan Li Dali Zhang Yinjie Gao; supported by the Beijing Municipal Foundation for Clinical Research[Z181100001718033];the Project for Prevention and Treatment of AIDS and Viral Hepatitis[2018ZX10301-404];the National Major Science and Technology Project of China[2019YFC0840704].; Background and aims:Cessation of nucleoside/nucleotide analogue(Nuc)therapy in patients with HBeAg-negative chronic hepatitis B(CHB)remains controversial.Methods:In this prospective,single-center cohort study,we recru...; 关键词：Nucleoside analogues Nucleotide analogues Therapy cessation HBeAg-negative Clinical relapse

A novel strain of Levilactobacillus brevis PDD-5 isolated from salty vegetables has beneficial effects on hyperuricemia through anti-inflammation and improvement of kidney damage被引量：1: 《Food Science and Human Wellness》2024年第2期898-908,共11页Jue Xu Maolin Tu Xiankang Fan Yuxing Guo Tao Zhang Xiaoqun Zeng Zhendong Cai Zhen Wu Daodong Pan; the National Natural Science Foundation of China(31972048,32272339);the National Key R&D Program of China(2021YFD2100104)for financial support。; Hyperuricemia is a metabolic disorder caused by abnormal purine metabolism,resulting in abnormally high serum uric acid.In this study,a novel Levilactobacillus brevis PDD-5 isolated from salty vegetables was verified ...; 关键词：Lactic acid bacteria Purine nucleoside HYPERURICEMIA Uric acid nephropathy

Mitochondrial deoxyguanosine kinase is required for female fertility in mice: 《Acta Biochimica et Biophysica Sinica》2024年第3期427-439,共13页Yake Gao Rui Dong Jiacong Yan Huicheng Chen Lei Sang Xinyi Yao Die Fan Xin Wang Xiaoyuan Zuo Xu Zhang Shengyu Yang Ze Wu Jianwei Sun; This work was supported by the grants from the National Natural Science Foundation of China(Nos.82273460,32260167,82360305 and 32270981);the Yunnan Applied and Basic Research Program(No.202101AV070002);the Major Science and Technique Programs in Yunnan Province(Nos.202102AA310055 and 202302AA310044);grants from Yunnan University(Nos.KC-22221062,ZC-22223104,ZC-23236296 and TM-23236924);the Excellent Doctor Program(No.XDYC-MY-2022-0055).; Mitochondrial homeostasis plays a pivotal role in oocyte maturation and embryonic development.Deoxyguanosine kinase(DGUOK)is a nucleoside kinase that salvages purine nucleosides in mitochondria and is critical for mit...; 关键词：DGUOK INFERTILITY MITOCHONDRIA nucleoside salvage pathway oocyte maturation

Restoration of Motor Function through Delayed Intraspinal Delivery of Human IL-10-Encoding Nucleoside-Modified mRNA after Spinal Cord Injury被引量：3: 《Research》2023年第4期131-144,共14页LászlóGál Tamás Bellák Annamária Marton Zoltán Fekécs Drew Weissman Dénes Török Rachana Biju Csaba Vizler Rebeka Kristóf Mitchell B.Beattie Paulo J.C.Lin Norbert Pardi Antal Nógrádi Krisztián Pajer; N.P.was supported by NIH R01-AI153064.C.V.and A.M.received generous support from the following grants:2020-1.1.6-JÖVŐ2021-00012 and 2022-2.1.1-NL-2022-00008 for the National Biotechnology Laboratory.A.N.was supported by the NKFIH KLINO-117031 grant.; Efficient in vivo delivery of anti-inflammatory proteins to modulate the microenvironment of an injured spinal cord and promote neuroprotection and functional recovery is a great challenge.Nucleoside-modified messenge...; 关键词：protective RESTORATION utilized

Nucleoside deaminases:the key players in base editing toolkit: 《Biophysics Reports》2023年第6期325-337,共13页Jiangchao Xiang Wenchao Xu Jing Wu Yaxin Luo Bei Yang Jia Chen; supported by National Key Research and Development Program National Key R&D Program of China(2023YFC3403400,2018YFA0801401 and 2019YFA0802804);the National Natural Science Foundation of China(32371514 and 32070170);Ministry of Agriculture and Rural Affairs of the People’s Republic of China(NK2022010207);Shanghai Municipal Science and Technology Commission(21JC1404600 and 23ZR1442500);Program of Shanghai Academic/Technology Research Leader(23XD1422500);Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine,Shanghai Tech University; The development of nucleoside deaminase-containing base editors realized targeted single base change with high efficiency and precision.Such nucleoside deaminases include adenosine and cytidine deaminases,which can ca...; 关键词：Nucleoside deaminase Base editors

Catalyst-Free Regio-and Diastereoselective Synthesis of Heterocyclic Nucleosides in the Eco-friendly Solvent 2-Methyltetrahydrofurant: 《Chinese Journal of Chemistry》2023年第2期167-172,共6页Xiaodong Gu Qingwei Du Weijian Song Jun(Joelle)Wang; We gratefully acknowledge HKBU RC-Tier 2 Start-up Grant for financial support.; An efficient and practical synthesis of heterocyclic nucleosides is developed by a catalyst-free highly regioselective and diastereose-lective[3+2]annulation of a-purine-substituted acrylates with nitrones.The reactio...; 关键词：HETEROCYCLE NUCLEOSIDE CATALYST-FREE ANNULATION Regioselectivity Synthetic methods Cycloaddition

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