Amoenucles A-F,novel nucleoside derivatives with TNF-α inhibitory activities from Aspergillus amoenus TJ507  

作　　者：Yeting Zhang Zhengyi Shi Chunhua Zhao Lanqin Li Ming Chen Yunfang Cao Fengqing Wang Bo Tao Xinye Huang Jieru Guo Changxing Qi Weiguang Sun Yonghui Zhang 

机构地区：[1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [2]Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Key Laboratory of Organ Transplantation,Ministry of Education,NHC Key Laboratory of Organ Transplantation,Chinese Academy of Medical Sciences,Wuhan 430030,China [3]Department of Pharmacy,Tongji Hospital,Tongji Medical college,Huazhong University of Science and Technology,Wuhan 430033,China

出　　处：《Chinese Journal of Natural Medicines》2025年第1期111-118,共8页中国天然药物(英文版)

基　　金：supported by the National Natural Science Foundation for Distinguished Young Scholars (No. 81725021);the National Natural Science Foundation of China (Nos.82003633 and 82173705)。

摘　　要：Amoenucles A-F(1-6),six previously undescribed nucleoside derivatives,and two known analogs(7 and 8)were isolated from the culture of Aspergillus amoenus TJ507.Their structures were elucidated through spectroscopic analysis,single-crystal X-ray crystallography,and chemical reactions.Notably,3 and 4 represent the first reported instances of nucleosides with an attached pyrrole moiety.Of particular significance,the absolute configuration of the sugar moiety of 1-4 was determined using nuclear magnetic resonance(NMR),electric circular dichroism(ECD)calculations,and a hydrolysis reaction,presenting a potentially valuable method for confirming nucleoside structures.Furthermore,1,2,and 5-8 exhibited potential tumor necrosis factorα(TNF-α)inhibitory activities,which may provide a novel chemical template for the development of agents targeting autoimmune and inflammatory diseases.

关 键 词：Aspergillus amoenus TJ507 Nucleoside derivatives Intramolecular transesterification Tumor necrosis factorα(TNF-α) 

分 类 号：R914[医药卫生—药物化学]