Amyloid fibrils are highly organized protein or peptide aggregates,often characterized by a distinctive supramolecular cross-β-sheet structure.The formation and accumulation of these structures have been traditionall...
supported by the National Key Research and Development Program of China(2019YFA0905100);the National Natural Science Foundation of China(21991102,22378227).
Constructing a framework carrier to stabilize protein conformation,induce high embedding efficiency,and acquire low mass-transfer resistance is an urgent issue in the development of immobilized enzymes.Hydrogen-bonded...
Vicinal diamines are key motifs widely-found in many pharmaceuticals and biologically active molecules.An appealing approach for synthesizing these molecules is the amination of enamines,but few examples have been exp...
Chiral cyclic amino alcohols with contiguous stereocenters are key building blocks in the synthesis of bioactive molecules and pharmaceuticals.Artificial cascade biocatalysis represents an attractive method for the sy...
funded by the National Natural Science Foundation of China(Nos.22322705,22171243,22301276);National Key Research and Development Program of China(No.2021YFC2102000);Zhejiang Provincial Natural Science Foundation of China(No.LQ24B020009);Scientific Research Starting Foundation of Zhejiang University of Technology(No.2020105009029).
The concurrent implementation of cascade reactions that combine biocatalysis and chemocatalysis is a challenging undertaking.Electrocatalysis provides versatile catalytic abilities and allows for mild reaction conditi...
the financial support from the National Natural Science Foundation of China(No.22274159)。
The construction of enzyme reactors based on metal-organic frameworks(MOFs)as the immobilized matrix is a proven strategy that has achieved the widespread application of enzymes across industries.Although many MOFs an...
supported by the National Key Research and Development Program of China(2021YFC2101500);the National Natural Science Foundation of China(22277111 and 22107094);Taishan Scholar Project(TSTP20221114);Department of Science and Technology of Shandong Province(2020CXGC010601,ZR2023ZD45,and ZR2021QB061).
Comprehensive Summary,N,N,N-Trimethyl-D-glucosamine(TMG)-chitotriomycin,a naturally occurring chitin related oligosaccharide,is a specificβ-N-acetylhexosaminidases(HexNAcases)inhibitor for insects and fungi.Although ...
the National Key R&D Program of China(No.2021YFF1200203 to G.W.and 2018YFA0903500 to F.Z.);Hubei Provincial Key R&D program(2021BAA168 to Y.W.);Shen-Zhen Science and Technology Program(JCYJ20220530160805011 to F.Z.);the interdisciplinary research program of Huazhong University of Science and Technology(HUST)(2023JCYJ001 to F.Z.);the China Postdoctoral Science Foundation(2023M741259 to X.Y.)for financial supports.
Comprehensive Summary The implementation of divergent protein engineering on the natural transaminase Vf-ω-TA led to the development of two effective mutants(M2 and M8),enabling the enzymatic synthesis of chiral amin...
supported by the National Key R&D Program of China (2018YFA0901700);National Natural Science Foundation of China (22278241);a grant from the Institute Guo Qiang, Tsinghua University (2021GQG1016);Department of Chemical Engineering-iBHE Joint Cooperation Fund。
The increasing atmospheric carbon dioxide (CO_(2)) concentration has exposed a series of crises in the earth's ecological environment.How to effectively fix and convert carbon dioxide into products with added value ha...
supported by the National Key Research and Development Program of China(2020YFA0210800);the National Natural Science Foundation of China(22334004,22027805,22277011,22107019,22176035);the Major Project of Science and Technology of Fujian Province(2020HZ06006)。
Chemical warfare agents represent a severe threat to mankind and their efficient decontamination is a global necessity.However,traditional disposal strategies have limitations,including high energy consumption,use of ...