TRANSAMINASE

作品数：36被引量：88H指数：5
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相关领域：医药卫生更多>>
相关作者：陈孝辛志勇徐惠君马有志李辉更多>>
相关机构：中国农业科学院作物育种栽培研究所华中科技大学中国中医科学院西苑医院东吴大学更多>>
相关期刊：《Journal of Ocean University of China》《World Journal of Gastroenterology》《Oncology and Translational Medicine》《Advances in Enzyme Research》更多>>
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Mild liver injury following withdrawal of long-term prednisonetherapy: A case report
《World Journal of Gastroenterology》2025年第4期144-150,共7页Jing-Wen Zhu Jun Yan Zhi-Han Zhang Tian-Qi Wang 
BACKGROUND Liver injury manifesting as hepatic enzyme abnormalities,has been occasionally identified to be a feature of primary or secondary Addison's disease,an uncommon endocrine disease characterized by adrenal ins...
关键词：Liver injury TRANSAMINASE PREDNISONE Addison's disease Adrenal insufficiency Case report 
Divergent Protein Engineering of Transaminase for the Synthesis of Chiral Rivastigmine and Apremilast Precursors
《Chinese Journal of Chemistry》2024年第19期2335-2340,共6页Langyu Tang Xinjie Yang Ningning Sun Guojiao Wu Yuzhou Wu Fangrui Zhong 
the National Key R&D Program of China(No.2021YFF1200203 to G.W.and 2018YFA0903500 to F.Z.);Hubei Provincial Key R&D program(2021BAA168 to Y.W.);Shen-Zhen Science and Technology Program(JCYJ20220530160805011 to F.Z.);the interdisciplinary research program of Huazhong University of Science and Technology(HUST)(2023JCYJ001 to F.Z.);the China Postdoctoral Science Foundation(2023M741259 to X.Y.)for financial supports.
Comprehensive Summary The implementation of divergent protein engineering on the natural transaminase Vf-ω-TA led to the development of two effective mutants(M2 and M8),enabling the enzymatic synthesis of chiral amin...
关键词：Asymmetric catalysis Chiral amine Protein engineering Directed evolution BIOCATALYSIS TRANSAMINASE ENANTIOSELECTIVITY Syntheticmethods AMINATION Enzymes 
Branched-chain amino acid transaminase 1 confers EGFRTKI resistance through epigenetic glycolytic activation
《Signal Transduction and Targeted Therapy》2024年第9期4103-4119,共17页Tao Zhang Zilu Pan Jing Gao Qingqing Wu Gang Bai Yan Li Linjiang Tong Fang Feng Mengzhen Lai Yingqiang Liu Peiran Song Yi Ning Haotian Tang Wen Luo Yi Chen Yan Fang Hui Zhang Qiupei Liu Yudi Zhang Hua Wang Zhiwei Chen Yi Chen Meiyu Geng Hongbin Ji Guilong Zhao Hu Zhou Jian Ding Hua Xie 
supported by grants from the National Natural Science Foundation of China(82273948 and 81903638);High-level Innovative Research Institute(2021B0909050003);State Key Laboratory of Drug Research(SKLDR-2023-TT-01 and SIMM2205KF-09);Lingang Laboratory(LG202103-02-02);Institutes for Drug Discovery and Development,Chinese Academy of Sciences(CASIMM0120225003-1 and-2);Guangdong Basic and Applied Basic Research Foundation(2021A1515010197 and 2023A1515012259);Zhongshan Municipal Natural Science Foundation(200805173640573 and 210730214049987);Project of Shanghai Institute of Materia Medica,Chinese Academy of Sciences(SIMM0120231001).
Third-generation EGFR tyrosine kinase inhibitors(TKIs),exemplified by osimertinib,have demonstrated promising clinical efficacy in the treatment of non-small cell lung cancer(NSCLC).Our previous work has identified AS...
关键词：METABOLISM IMPAIRED RESISTANCE 
Getting Physical before a Medical Physical and How It Leads to Doctor Becoming Patient: A Curious Case of Transient Raised Transaminases
《Open Journal of Gastroenterology》2024年第8期261-266,共6页Peter Cassar Nicholas Delicata 
This case report sheds light on a curious case of rhabdomyolysis in an otherwise healthy twenty-eight-year-old male and its direct effect on liver function tests. This case report provides a fresh perspective on the d...
关键词：RHABDOMYOLYSIS TRANSAMINASE Creatinine Kinase 
Analysis and Characterization of the GABA Transaminase and Succinate Semialdehyde Dehydrogenase Genes in the Microalga Isochrysis zhanjiangensis in Response to Abiotic Stresses
《Journal of Ocean University of China》2024年第3期775-785,共11页TIAN Jiaojiao ZHANG Lin LU Xinyue YE Lingzhi WU Yuanyuan CHEN Deshui CAO Jiayi JIANG Jiaxin XU Jilin YAN Xiaojun 
supported by the Zhejiang Provincial Natural Science Foundation of China(No.LY22C190001);the Natural Science Foundation of Ningbo Government(No.2021J114);the Ningbo Science and Technology Research Projects,China(No.2019B10006);the Zhejiang Provincial Department of Education Scientific Research Project(No.Y202249030);the Earmarked Fund for CARS-49;partly sponsored by K.C.Wong Magna Fund in Ningbo University.
Gamma-aminobutyric acid(GABA),widely existing in different organisms,is rapidly accumulated in plants in response to environmental stresses.The main biosynthesis and degradation pathways of GABA constitute the GABA sh...
关键词：abiotic stress GABA heterologous expression Isochrysis zhanjiangensis TRANSCRIPTION 
Pocket Modification of x-Amine Transaminase AtATA for Overcoming the Trade-Off Between Activity and Stability Toward 1-Acetonaphthone被引量：1
《Engineering》2023年第11期203-214,共12页Jiaren Cao Fangfang Fan Changjiang Lyu Sheng Hu Weirui Zhao Jiaqi Mei Shuai Qiu Lehe Mei Jun Huang 
National Natural Science Foundation of China(32071268 and 31971372);the Ningbo"Scientific and Technological Innovation 2025"Key Project(2020Z080)for financial support。
Amine transaminases(ATAs)catalyze the asymmetric amination of prochiral ketones or aldehydes to their corresponding chiral amines.However,the trade-off between activity and stability in enzyme engineering represents a...
关键词：Trade-off CO-EVOLUTION Amine transaminase (R)-(+)-1(1-naphthyl)ethylamine 
Diagnostic value of methylated branched chain amino acid transaminase 1/IKAROS family zinc finger 1 for colorectal cancer被引量：1
《World Journal of Gastroenterology》2023年第36期5240-5253,共14页Ke Xu Ai-Ru Yu Shen-Bin Pan Jie He 
Supported by Natural Science Foundation of Sichuan Province,No.2023NSFSC0729;Wu Jieping Foundation Special Fund for Clinical Research,No.320.6750.2022-19-100;Foundation of Key Clinical Specialty of Sichuan Province,No.2022;School Foundation of Chengdu Medical College,No.CYZYB21-05.
BACKGROUND The diagnostic value of combined methylated branched chain amino acid transaminase 1(BCAT1)/IKAROS family zinc finger 1(IKZF1)in plasma for colorectal cancer(CRC)has been explored since 2015.Recently,severa...
关键词：Branched chain amino acid transaminase 1 IKAROS family zinc finger 1 METHYLATION Liquid biopsy Colorectal cancer 
Effect of Purified Paper Wasp Ropalidia marginata Venom Toxin Enzyme Activity in Blood Serum, Liver, and Gastrocnemius Muscle of Albino Mice
《Advances in Enzyme Research》2023年第3期113-145,共33页Simran Sharma Ravi Kant Upadhyay 
In the present, investigation effects of sub-lethal dose of purified paper wasp Ropalidia marginata venom toxins were evaluated on important metabolic enzymes i.e. ALP ACP, GPT, GOT, LDH, and AchE enzyme activity in s...
关键词：Ropalidia marginata SERUM Liver and Rectus Abdominis GASTROCNEMIUS Muscle Atria and Ventricle Acid Phosphatase (ACP) Alkaline Phosphatase (ALP) Glutamate Pyruvate Transaminase (GPT) and Glutamate Oxaloacetate Transaminase (GOT) Lactic Dehydrogenase (LDH) Acetylcholinesterase (AchE) 
Effects of Purified Indian Cattle Tick Rhipicephalus microplus Saliva Toxins on Various Enzymes in Blood Serum, Liver and Muscles of Albino Mice
《Advances in Enzyme Research》2023年第2期82-112,共31页Nidhi Yadav Ravi Kant Upadhyay 
In the present investigation, in vivo effects of purified ticks’ saliva toxin were evaluated on the level of certain important cellular metabolic enzymes i.e. acid phosphatase (ACP), alkaline phosphatase (ALP), gluta...
关键词：Rhipicephalus microplus SERUM Liver and Rectus Abdominis GASTROCNEMIUS Muscle Atria and Ventricle Acid Phosphatase (ACP) Alkaline Phosphatase (ALP) Glutamate Pyruvate Transaminase (GPT) and Glutamate Oxaloacetate Transaminase (GOT) Lactic Dehydrogenase (LDH) and Acetylcholinesterase (AchE) 
Enzymatic and chemo-enzymatic strategies to produce highly valuable chiral amines from biomass withω-transaminases on 2D zeolites
《National Science Review》2022年第9期5-13,共9页J.Miguel Carceller Karen S.Arias Maria J.Climent Sara Iborra Avelino Corma 
supported by the Spanish Government through the‘Severo Ochoa Program’(SEV-2016–0683);the PGC2018-097277-B-100(MCIU/AEI/FEDER,UE)Project。
Amino transaminases(ATAs)have been supported on a 2D ITQ-2 zeolite through electrostatic interactions,resulting in a highly stable active biocatalyst to obtain a variety of valuable chiral amines starting from prochir...
关键词：amino transaminase ITQ-2 zeolite chemo-enzymatic process BIOMASS semi-continuous process Pd/MgO 
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