Vicinal diamines are key motifs widely-found in many pharmaceuticals and biologically active molecules.An appealing approach for synthesizing these molecules is the amination of enamines,but few examples have been exp...
supported by the National Natural Science Foundation of China(22122107).
The synthesis of N-glycosides has received significant attention due to their crucial role in carbohydrate chemistry.Despite considerable advancements developed in the construction of N-glycosides,methods for the ster...
supported by the National Natural Science Foundation of China(22171043,22193012,221831002);the Fundamental Research Funds for the Central Universities-Excellent Youth Team Program(2412023YQ001);Ten Thousand Talents Program for generous financial support。
Enantioenriched pyrrolidines and derivatives are ubiquitous substructures in compounds of importance to medicinal and biological chemistry.Herein,we report an efficient cobalt-catalyzed intramolecular asymmetric hydro...
financial supports from the Natural Science Foundation of Zhejiang Province(LY21B020005);the National Natural Science Foundation of China(21202152).
Fused polycyclic N-heterocycles are very important scaffolds in biomedicinal chemistry and materials science.Intramolecular alkyne hydroamination is a powerful method for the construction of N-heterocycles.In the last...
Financial supports were provided by the National Key R&D Program of China(2021YFA1500200 and 2021YFF0701600);the NSFC(22271249);the Fundamental Research Funds for the Central Universities(226-2022-00224 and 226-2023-00115).
Here,we report a cobalt-catalyzed sequential dehydrogenative Heck silylation/hydroamination of styrenes with hydrosilane and diazo compound to access 1-amino-2-silyl compounds with excellent regioselectivity.This difu...
the National Natural Science Foundation of China(NSFC 21971102);Guangdong Innovative Program(2019BT02Y335)for financial support.
γ-Aminobutyric acid is a major inhibitory neurotransmitter in the mammalian central nervous system that plays a substantial role in brain disorders.γ-Amino phosphonic acid is a unique surrogate of both natural and u...
We declare no competing financial interests or personal relationships exiting in this article.And our work was supported by the National Natural Science Foundation of China(No.31972287).
Cheap metal(Fe,Mn,and Co)-catalyzed hydroamination of alkenes has been an attractive method for synthesis of amines because of biocompatibility of metal,excellent Markovnikov selectivity and chemoselectivity.However,m...
the financial support from National Natural Science Foundation of China(No.22001121 and 21772093);Natural Science Foundation of Jiangsu Province(BK20180690);National Students’Platform for Innovation and Entrepreneurship Training Program(202110291019Z);Nanjing Tech University(Start-up Grant No.39837118 and 39837146).
An efficient defluorinative net-[3+3]-cyclization strategy for the construction of perfluoroalkyl-substituted pyrimidine derivatives by using a series of perfluoroalkyl alkynes and amidines as starting materials was d...
supported by the National Natural Science Foundation of China(Nos.22073066,21503143 and 21975179);the Natural Science Foundation of Tianjin(No.16JCQNJC05600)。
Density functional theory calculations have been performed to investigate the dipeptide phosphinecatalyzed hydroamination of enones with pyridazinones.The computations reveal that a number of the N-H...O hydrogen-bond...
by the National Natural Science Foundation of China(21702102 and 21772087),NSF of Jiangsu Province(BK20190281);the Six Kinds of Talent Project of Jiangsu Province(JNHB-003);the Program for High-Level Entrepreneurial and Innovative Talents Introduction of Jiangsu Province(Group Program).
Direct and positionally selective aliphatic C–H functionalization is an attractive means with which to streamline chemical synthesis.With many possible reaction sites,most traditional methods need a polar-directing g...