PYRIMIDINE

作品数：185被引量：165H指数：7
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相关领域：理学更多>>
相关作者：余从煊周松刘敬镛徐洪耀徐耀春更多>>
相关机构：中国科学院浙江工业大学之江学院北京理工大学中国药科大学更多>>
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相关基金：国家自然科学基金湖北省自然科学基金中国博士后科学基金国家重点基础研究发展计划更多>>
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Pyrimidine derivative as eco-friendly corrosion inhibitor for nickel−aluminum bronze in seawater
《Transactions of Nonferrous Metals Society of China》2025年第1期207-224,共18页Jin-yu PI Qi WANG Chao-yang FU 
supported by the National Natural Science Foundation of China(No.52171069).
A pyrimidine derivative,6-phenyl-2-thiouracil(PT),was synthesized for developing a corrosion inhibitor(CI)applied in the protection of the nickel−aluminum bronze(NAB)in seawater.The anti-corrosion effect of PT was eva...
关键词：nickel−aluminum bronze corrosion inhibitor diffusion coefficient ADSORPTION seawater 
Benzo[4,5]imidazo[1,2-a]pyrimidine-based structure-inherent targeting fluorescent sensor for imaging lysosomal viscosity and diagnosis of lysosomal storage disorders
《Chinese Chemical Letters》2024年第11期454-460,共7页Jiao Chen Zihan Zhang Guojin Sun Yudi Cheng Aihua Wu Zefan Wang Wenwen Jiang Fulin Chen Xiuying Xie Jianli Li 
supported by the National Natural Science Foundation of China(Nos.22077099,22171223 and 22307102);the Innovation Capability Support Program of Shaanxi(Nos.2023-CXTD-75 and 2022KJXX-32);the Technology Innovation Leading Program of Shaanxi(Nos.2023KXJ-209 and 2024QCY-KXJ-142);the Key Research and Development Program of Shaanxi(No.2024GHZDXM-22);the Natural Science Basic Research Program of Shaanxi(Nos.2023-JC-YB-141 and 2022JQ-151);Young Talent Fund of Association for Science and Technology in Shaanxi,China(No.SWYY202206);the Shaanxi Fundamental Science Research Project for Chemistry&Biology(Nos.22JHZ010 and 22JHQ080);the Yan’an City Science and Technology Project(No.2022SLZDCY-002)。
Benzo[4,5]imidazo[1,2-a]pyrimidine-based derivatives play crucial roles in medicines,pesticides,tracers and photoelectric materials.However,their synthesis approach still needs to be optimized,and their fluorescent pr...
关键词：Fluorescent sensor Benzo[4 5]imidazo[1 2-a]pyrimidine Lysosome VISCOSITY Lysosomal storage disorders Structure-inherent targeting Fluorescence imaging 
Pyrimidine-containing covalent organic frameworks for efficient photosynthesis of hydrogen peroxide via one-step two electron oxygen reduction process
《Nano Research》2024年第11期9498-9506,共9页Hongyu Chen Hao Zhang Kai Chi Yan Zhao 
financially supported by the Nation Key Research and Development(R&D)Program of China(No.2022YFB3603804);Natural Science Foundation of Shanghai(No.22ZR1407800).
The photocatalytic oxygen reduction reaction (ORR), particularly the one-step two-electron (2e−) pathway, is a highly promising strategy for efficient and selective hydrogen peroxide (H_(2)O_(2)) synthesis. However, c...
关键词：covalent organic frameworks photocatalysis hydrogen peroxide oxygen reduction reaction pyrimidine units 
Visible-Light-Induced Domino Cyclization to Access Pyrido[2,3-d]pyrimidine-2,4-diones via a Radical-Polar Crossover Reaction
《Chinese Journal of Chemistry》2024年第19期2346-2350,共5页Wanqing Zuo Yu Cheng Zhizhen Zhu Lingling Zuo Xiao Geng Zhifang Li Lei Wang 
the National Natural Science Foundation of China(22071171);the Natural Science Foundation of Zhejiang Province(LZ22B020003)for financial support of this work.
Comprehensive Summary Catalytic and green strategies for the synthesis of privileged scaffolds are synthetically appealing.We now report a radical-polar crossover(RPC)-enabled three-component cyclization of bromodiflu...
关键词：Photocatalysis HETEROCYCLES RADICALS Bromodifluoroalkyls 6-Aminouraciles ENAMINONES 
NH_(4)SCN-Promoted Formal[3+3]Annulation for the Synthesis of 5-Arylated Pyrazolo[1,5-a]pyrimidines
《有机化学》2024年第9期2832-2840,共9页Li Longlong He Xinyue Zhou Longsheng Qu Hengtong Feng Chengtao Xu Kun 
安徽省自然科学基金(No.2008085MB50);安徽省高校自然科学研究重点(No.KJ2021A0598)资助项目.
A formal[3+3]annulation of 3-aminopyrazoles with cinnamaldehydes or cinnamyl alcohols mediated by NH_(4)SCN has been developed.This protocol provides a practical route to construct 5-arylated pyrazolo[1,5-a]pyrimidine...
关键词：tandem cyclization hypervalent iodine regioselectivity pyrazolo[1 5-a]pyrimidine CINNAMALDEHYDE 
Synthesis and molecular docking of pyrimidine derivatives as antibacterial agents
《Carbon Resources Conversion》2024年第3期32-40,共9页Karthikeyan Elumalai Anandakumar Shanmugam Mahalakshmi Devaraji Sivaneswari Srinivasan 
In this study,we aimed to synthesise and evaluate the antimicrobial activity of sulphanilamide-condensed pyrimidine derivatives.The compounds were synthesised using a one-pot,three-component reaction.The structures of...
关键词：Pyrimidine derivative COMPOUNDS Binding energy Active site Antibacterial activity 
A unique role of the pyrimidine de novo synthesis enzyme ODCase in Lysobacter enzymogenes
《Journal of Integrative Agriculture》2024年第9期3066-3077,共12页Mingming Yang Yunxiao Tan Jiabing Ma Yingjia Zhao Xia Yan Nana Wang Pingping Wang Jiaqi Tan Suilong Ai Xiaofei Liang Bangshuai Chang Obadah E.A.Yousif Chao Zhao Bo Wang Guoliang Qian Lili Huang 
supported by the National Natural Science Foundation of China(32102283 to Mingming Yang);the Science and Technology Major Project of China National Tobacco Corporation(110202101056(LS-16));the Science and Technology Project of Shaanxi Branch of China National Tobacco Corporation(KJ-2021-02 and KJ-2022-04).
Bacterial species of the genus Lysobacter are environmentally ubiquitous with strong antifungal biocontrol potential.Heat-stable antifungal factor(HSAF)secreted by the biocontrol bacterium Lysobacter enzymogenes OH11 ...
关键词：ODCase pyrimidine de novo synthesis secondary metabolite HSAF Lysobacter enzymogenes 
Heterogeneous photocatalytic methanol oxidation coupled with oxygen reduction toward pyrimidines synthesis
《Science Bulletin》2024年第16期2496-2500,共5页Hongru Wu Jie Wang Hongli Sun Haochuan Jing Zhenyuan Teng Wei Ou Zhaofei Zhang Yangsen Xu Bin Liu Chenliang Su 
supported by the National Key Research and Development Program of China(2021YFA1600800);the National Natural Science Foundation of China(21972094,22372102,and22102102);the Educational Commission of Guangdong Province(839-0000013131);Guangdong Basic and Applied Basic Re-search Foundation(2020A1515010982);Shenzhen Science and Technology Program(RCJC20200714114434086 and 20221425);the Research Team Cultivation Program of Shenzhen University(2023QNT013)。
Pyrimidines and their derivatives are widely found in natural products,agrochemicals,and pharmaceutical compounds,such as osimertinib,tofacitinnib,nilotinib,and fluoxastrobin(Fig.S1 online)[1].Considering their signif...
关键词：PYRIMIDINE METHANOL SYNTHESIS 
Covalent organic frameworks/carbon nanotubes composite with cobalt(II)pyrimidine sites for bifunctional oxygen electrocatalysis
《Nano Materials Science》2024年第4期419-427,共9页Zhuangzhuang Wu Lijuan Feng Zhe Lu Xinxin Yu Yuzhen Zhao Junming Luo Shaolei Wang Xinlong Tian Qi Chen 
supported by the Hainan Province Science and Technology Special Fund(ZDYF2022SHFZ299);the National Natural Science Foundation of China(Nos.52063014 and 51873053)。
With characteristics and advantages of functional composite materials,they are commendably adopted in numerous fields especially in oxygen electrocatalysis,which is due to the significant synergies between various com...
关键词：Oxygen electrocatalysis Covalent organic frameworks Carbon nanotubes Composite materials 
Design and optimization of piperidinesubstituted thiophene[3,2-d]pyrimidine-based HIV-1 NNRTIs with improved drug resistance and pharmacokinetic profiles
《Acta Pharmaceutica Sinica B》2024年第7期3110-3124,共15页Yanying Sun Zhenzhen Zhou Zhongling Shi Fabao Zhao Minghui Xie Zongji Zhuo Erik De Clercq Christophe Pannecouqueb Dongwei Kang Peng Zhan Xinyong Liu 
financial support from the National Natural Science Foundation of China(NSFC Nos.81973181,82273773);Shandong Provincial Natural Science Foundation(ZR2020YQ61,ZR2020JQ31,China);Qilu Young Scholars Program of Shandong University and Taishan Scholar Program at Shandong Province.
HIV-1 reverse transcriptase(RT)has received great attention as an attractive therapeutic target for acquired immune deficiency syndrome(AIDS),but the inevitable drug resistance and side effects have always been major ...
关键词：HIV-1 NNRTIS NNIBP Structural alert Anti-HIV-1 drug candidate 
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