GLYCOPEPTIDES

作品数：31被引量：31H指数：4
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相关领域：医药卫生生物学更多>>
相关作者：刘永强王岩周秋丽池岛乔杨明更多>>
相关机构：长春中医学院吉林省中医中药研究所吉林大学山东大学更多>>
相关期刊：《Asian Journal of Pharmaceutical Sciences》《Journal of Microbiology and Immunology》《National Science Review》《Biophysics Reports》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划上海市浦江人才计划项目北京市自然科学基金更多>>
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Photoredox-catalyzed C-glycosylation of peptides with glycosyl bromides
《Chinese Chemical Letters》2024年第6期263-267,共5页Chen Li Ziyuan Zhao Shouyun Yu 
supported by National Natural Science Foundation of China(No.22171133);State Key Laboratory of Analytical Chemistry for Life Science(No.5431ZZXM2308)。
Glycosyl radicals,produced under mild photoredox conditions,show unique utility in the preparation of C-linked glycoconjugates.We herein report the construction of C-glycosidic bonds on α,β-dehydroalanine(DHA)of pep...
关键词：Glycosylation C-GLYCOSIDES GLYCOPEPTIDES DEHYDROALANINE Photoredox catalysis 
Encouraging Solution to the Problem of Synthesizing Protein α-Thioester被引量：1
《Chinese Journal of Chemistry》2024年第10期1114-1120,共7页Xinliang Liu Zijun Gao Jie Zhao Farong Ye Ping Huang Ping Wang 
supported by the National Science Fund for Distinguished Young Scholars(22225701);the Interdisciplinary Program of Shanghai Jiao Tong University(20230102);the National Natural Science Foundation of China(22077080,92253302 and 22275122);the Shanghai Pilot Program for Basic Research Shanghai Jiao Tong University(21TQ1400210);the Special Projects of the Central Government in Guidance of Local Science and Technology Development(2021Szvup077);the China Post-doctoral Science Foundation(2023M732214).
Expressed protein ligation(EPL)provides a powerful tool to access large-size proteins with precise structures.Existing methods for constructing the critical protein thioester for EPL have predominantly relied on the r...
关键词：DESULFURIZATION GLYCOPROTEINS GLYCOPEPTIDES Protein expression Peptide thioester 
Recent Advances in Glycopeptide and Glycoprotein Synthesis:A Refined Synthetic Probe towards the Biological World被引量：1
《Chinese Journal of Chemistry》2023年第16期2010-2024,共15页Haoru Zhuang Huiran Hao Yongshun Qiu Jinjuan Gan Tianlu Li 
Shenzhen Fundamental Research Program(RCBS20200714114957255);the National Natural Science Foundation of China(Grant No.22177061);the National Key Research and Development Program of China(2018YFA0902000);the Open Projects Fund of Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology(2021CCG01).
Comprehensive Summary Protein glycosylation is the most complex and diverse form of post-translational modification in human body.Meanwhile,glycosylation of peptides and proteins emerges as a promising strategy to imp...
关键词：GLYCOPROTEINS GLYCOPEPTIDES GLYCOSYLATION Total synthesis BIOSYNTHESIS Structure-activity relationships 
Application of StrucGP in medical immunology:site-specific N-glycoproteomic analysis of macrophages
《Frontiers of Medicine》2023年第2期304-316,共13页Pengfei Li Zexuan Chen Shanshan You Yintai Xu Zhifang Hao Didi Liu Jiechen Shen Bojing Zhu Wei Dan Shisheng Sun 
supported by the National Key Research and Development Program of China(No.2019YFA0905200);the National Natural Science Foundation of China(Nos.91853123,81773180,and 21705127).
The structure of N-glycans on specific proteins can regulate innate and adaptive immunity via sensing environmental signals.Meanwhile,the structural diversity of N-glycans poses analytical challenges that limit the ex...
关键词：macrophage GLYCOPROTEOME GLYCOPEPTIDES N-glycan structures PD-L1 
Design and fabrication of highly hydrophilic magnetic material by anchoring L-cysteine onto chitosan for efficient enrichment of glycopeptides
《Chinese Chemical Letters》2023年第3期148-152,共5页Binfen Zhao Wenhui Xu Jiutong Ma Qiong Jia 
financially supported by Open Project of State Key Laboratory of Supramolecular Structure and Materials,Jilin University,China(No.sklssm2022012);the Fundamental Research Funds for the Central Universities,JLU,China。
Hydrophilic interaction liquid chromatography(HILIC) has been recognized as an effective strategy for glycopeptide enrichment. Hydrophilic materials pave the way to solve the limit of low enrichment capacity and poor ...
关键词：CHITOSAN L-CYSTEINE Hydrophilic material GLYCOPEPTIDE ENRICHMENT 
Hydrophilic adamantane derivatives engineered β-cyclodextrin-based self-assembly materials for highly efficient enrichment of glycopeptides
《Chinese Chemical Letters》2023年第3期283-287,共5页Ping Li Zheng Li Dawei Zhang Qiong Jia 
financially supported by the Fundamental Research Funds for the Central Universities, Jilin University, China。
β-Cyclodextrin(β-CD) based materials have attracted great attention in the separation of hydrophilic glycopeptides due to the abundant hydroxyl groups in its exterior. However, the current materials based on β-CD g...
关键词：Β-CYCLODEXTRIN HYDROPHILIC SELF-ASSEMBLY ENRICHMENT GLYCOPEPTIDES 
Specific enrichment of urinary exosomes and exosomal glycopeptides by coefficient affinity of integrated L-cysteine and titania
《Chinese Chemical Letters》2023年第2期254-258,共5页Yijie Chen Haolin Chen Chenjie Yang Yonglei Wu Chunhui Deng Nianrong Sun 
supported by National Key R&D Program of China (No. 2018YFA0507501);the National Science Foundation for Distinguished Young Scholars of China (No. 21425518);the National Natural Science Foundation of China (Nos. 22074019, 22004017);Shanghai Sailing Program (No. 20YF1405300)。
Exosome and inclusive cargoes have manifested significant function in different biological events. In particular, glycopeptides in exosome are closely associated with occurrence and development of various diseases. De...
关键词：GLYCOPEPTIDES ENRICHMENT Nanomaterials EXOSOMES Urine 
High-throughput site-specific N-glycoproteomics reveals glyco-signatures for liver disease diagnosis被引量：2
《National Science Review》2023年第1期209-220,共12页Zhenyu Sun Bin Fu Guoli Wang Lei Zhang Ruofan Xu Ying Zhang Haojie Lu 
the National Key Research and Development Program of China(2020YFE0202200);the National Natural Science Foundation of China(22174021,21974025and 82121004);the project of Shanghai Key Laboratory of Kidney and Blood Purification;Shanghai Pujiang Program(2019PJD003);the Innovative Research Team of High-Level Local University in Shanghai。
The glycoproteome has emerged as a prominent target for screening biomarkers,as altered glycosylation is a hallmark of cancer cells.In this work,we incorporated tandem mass tag labeling into quantitative glycoproteomi...
关键词：GLYCOPROTEOMICS HIGH-THROUGHPUT quantification N-glycopeptides liver disease 
Enzymatic recovery of glycopeptides from different industrial grades edible bird’s nest and its by-products:nutrient,probiotic and antioxidant activities,and physicochemical characteristics被引量：1
《Food Science and Human Wellness》2022年第6期1555-1564,共10页Hidayati Syamimi Mohd Noor Rafi dah Mohd Ariff Lee Sin Chang Xin Yi Chai Hui Yan Tan Nur’Aliah Daud Abdul Salam Babji Seng Joe Lim 
funded by the Research Excellence Consortium(Konsortium Kecemerlangan Penyelidikan)(KKP/2020/UKMUKM/5/1)(JPT(BKPI)1000/016/018/25(21));the Fundamental Research Grant Scheme(FRGS/1/2019/WAB01/UKM/02/1)。
This study was conducted to recover edible bird’s nest(EBN)hydrolysates from different grades of EBN,including the industrial by-products,using enzymatic treatment.The nutrient,physicochemical properties and antioxid...
关键词：Edible bird’s nest by-products Enzymatic hydrolysis GLYCOPEPTIDES Lactobacillus plantarum Probiotic activity 
Xenopus GLP-1-based glycopeptides as dual glucagon-like peptide 1 receptor/glucagon receptor agonists with improved in vivo stability for treating diabetes and obesity被引量：1
《Chinese Journal of Natural Medicines》2022年第11期863-872,共10页LI Qiang YANG Qimeng HAN Jing LIU Xiaohan FU Junjie YIN Jian 
supported by the Fundamental Research Funds for the Central Universities(No.JUSRP51712B);the Natural Science Foundation of Xuzhou(No.KC19154);the Open Project Program of Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor,Ministry of Education,Guangxi Medical University(No.GKE-KF202006)。
Peptide dual agonists toward both glucagon-like peptide 1 receptor(GLP-1R)and glucagon receptor(GCGR)are emerging as novel therapeutics for the treatment of type 2 diabetes mellitus(T2DM)patients with obesity.Our prev...
关键词：Glucagon-like peptide-1 GLUCAGON DIABETES OBESITY O-GLCNACYLATION 
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