C-GLYCOSIDES

作品数:21被引量:39H指数:4
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相关领域:理学医药卫生更多>>
相关作者:陈世忠王弘肖培根卞庆亚曹丽更多>>
相关机构:北京大学中国医学科学院北京协和医学院更多>>
相关期刊:《Precision Chemistry》《Chinese Journal of Chemistry》《Synthetic and Systems Biotechnology》《Chinese Journal of Natural Medicines》更多>>
相关基金:国家自然科学基金高等学校学科创新引智计划北京市自然科学基金天津市自然科学基金更多>>
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Stereoselective synthesis of 2-deoxy-α-C-glycosides from glycals
《Chinese Chemical Letters》2024年第12期422-426,共5页Hongjin Shi Guoyin Yin Xi Lu Yangyang Li 
supported by grants from the Fundamental Research Funds for Central Universities(No.2042021kf0190)。
2-Deoxy-α-C-Glycosides are a significant class of carbohydrates found in numerous bioactive molecules and medicines.Developing a concise strategy for the assembly of theseα-configured C-glycosides is crucial in the ...
关键词:Nickel catalysis STEREOSELECTIVITY 2-Deoxy-α-C-glycosides Glycals Cross-coupling reaction 
Pd-Catalyzed Stereospecific Glycosyl Cross-Coupling of Reversed Anomeric Stannanes for Modular Synthesis of Nonclassical C‑Glycosides
《Precision Chemistry》2024年第11期587-599,共13页Guoqiang Cheng Bo Yang Yang Han Wei Lin Siyuan Tao Yong Nian Yingzi Li Maciej A.Walczak Feng Zhu 
sponsored by the National Key R&D Program of China(Grant No.2023YFA1508800);National Science Foundation(Grant No.22301178);Shanghai Pilot Program for Basic Research-Shanghai Jiao Tong University(Grant No.21TQ1400210);Fundamental Research Funds for the Central Universities(Grant No.22X010201631);the Open Grant from the Pingyuan Laboratory(2023PY-OP-0102);Excellent Young Scientists Fund Program(Overseas),Natural Science Founda-tion of Shanghai(Grant No.21ZR1435600);Shanghai Sailing Program(Grant No 21YF1420600);start-up fundings from Shanghai Jiao Tong University(SJTU);Part of this study was supported by the National Science Foundation(Grant No.82204192 to Y.N.);National Key R&D Program of China(Grant No.2023YFC2308200 to Y.N.);Natural Science Foundation of Jiangsu Province(BK20220471 to Y.N.);Beatriu de Pinós programme from AGAUR(Grant No.2022 BP 00055 to Y.L);the China Postdoctoral Science Foundation(2022M722071 to B.Y.).
Nonclassical C-glycosides,distinguished by their unique glycosidic bond connection mode,represent a promising avenue for the development of carbohydrate-based drugs.However,the accessibility of nonclassical C-glycosid...
关键词:Glycosylation CROSS-COUPLING Nonclassical C-glycosides Reversed anomeric stannanes STEREOSPECIFICITY 
Photoredox-catalyzed C-glycosylation of peptides with glycosyl bromides
《Chinese Chemical Letters》2024年第6期263-267,共5页Chen Li Ziyuan Zhao Shouyun Yu 
supported by National Natural Science Foundation of China(No.22171133);State Key Laboratory of Analytical Chemistry for Life Science(No.5431ZZXM2308)。
Glycosyl radicals,produced under mild photoredox conditions,show unique utility in the preparation of C-linked glycoconjugates.We herein report the construction of C-glycosidic bonds on α,β-dehydroalanine(DHA)of pep...
关键词:Glycosylation C-GLYCOSIDES GLYCOPEPTIDES DEHYDROALANINE Photoredox catalysis 
C-Aryl Glycosylation via Interrupted Pummerer Rearrangement
《Chinese Journal of Chemistry》2023年第21期2843-2847,共5页Jiagen Li Xuefeng Jiang 
The authors are grateful for financial support provided by NSFC(22125103and21971065);STCSM(22JC1401000,20xD1421500 and 20JC1416800);the Fundamental Research FundsfortheCentral Universities.
C-aryl glycosides are an important kind of carbohydrate derivatives for drug discovery,due to their distinctive attributes of resistance to hydrolysis from enzymes.Herein,C-aryl glycosylation was established for the s...
关键词:GLYCAL GLYCOSYLATION Interrupted pummerer REARRANGEMENT SULFOXIDE Carbohydrates C-GLYCOSIDES Drug discovery 
C-Glycoside Synthesis Enabled by Nickel Catalysis被引量:4
《Chinese Journal of Chemistry》2023年第17期2217-2236,共20页Weidong Shang Rong Shi Dawen Niu 
the National Natural Science Foundation of China(21907071,21922106,and T2221004);Fok Ying Tung Education Foundation for financial support.
Comprehensive Summary,C-Glycosides are critical,naturally occurring products and medicinal candidates,and extensive efforts have been made to explore efficient approaches for creating C-glycosidic bonds.Transition-met...
关键词:C-GLYCOSIDES NICKEL GLYCOSYLATION Glycosyl radical Carbohydrates 
Highly Stereoselective C-Glycosylation by Photocatalytic Decarboxylative Alkynylation on Anomeric Position:A Facile Access to Alkynyl C-Glycosides被引量:2
《Chinese Journal of Chemistry》2022年第6期681-686,共6页Kailin Lu Yingying Ma Shihui Liu Shixun Guo Yongqiang Zhang 
Financial support from the program of the National Natural Science Foundation of China(No.21871086,Y.-Q.Z.)is gratefully acknowledged.
The highly stereoselective synthesis of diverse medicinally valuable alkynyl C-glycosides under mild and green reaction conditions remains a great challenge.Herein,we wish to report a visible-light induced photocataly...
关键词:Photocatalysis Anomeric position Decarboxylative alkynylation C-C coupling GLYCOSIDES 
Exploring the catalytic function and active sites of a novel C-glycosyltransferase from Anemarrhena asphodeloides被引量:1
《Synthetic and Systems Biotechnology》2022年第1期621-630,共10页Jia Huang Yaru She Jingyang Yue Yidu Chen Yu Li Jing Li Yonger Hu Deying Yang Jiabo Chen Lu Yang Zhongqiu Liu Ruibo Wu Pengfei Jin Lixin Duan 
the National Natural Science Foundation of China No.81874333;the Guangdong Foundation for Basic and Applied Basic Research No.2020A1515010926.
Anemarrhena asphodeloides is an immensely popular medicinal herb in China,which contains an abundant of mangiferin.As an important bioactive xanthone C-glycoside,mangiferin possesses a variety of pharmacological activ...
关键词:C-GLYCOSIDES Anemarrhena asphodeloides C-glycosyltransferases BENZOPHENONE Active sites 
Flavonoid C-glycosides from the seeds of Hovenia dulcis Thunb.被引量:3
《Journal of Chinese Pharmaceutical Sciences》2020年第11期813-818,共6页Fangfang Xu Biao Sun Xiaoqi Zhang Bo Liu 
National Natural Science Foundation of China(Grant Nos.81703379 and U1801287);Key-Area Research and Development Program of Guangdong Province(Grant No.2020B1111110007);Science and Technology Planning Project of Guangdong Province(Grant No.2018B020207008);Key Laboratory Program of Guangzhou(Grant 201902010082);the Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine(Grant Nos.YN2016QJ05 and YN2015MS03);Key Project of High-level University Construction of Guangzhou University of Chinese Medicine(Grant No.XK2018019)。
Ten known flavonoid C-glycosides identified as 2′′-O-β-D-glucopyranosyl isovitexin(1),spinosin(2),6′′′-acetyl spinosin(3),6′′′-p-hydroxycinnamoyl-2′′O-β-D-glucopyranosyl isovitexin(4),6′′′-p-hydroxy-cin...
关键词:Hovenia dulcis Thunb Chemical constituents Flavonoid C-glycosides 
Synthesis of non-classical heteroaryl C-glycosides via Minisci-type alkylation of N‑heteroarenes with 4-glycosyl-dihydropyridines被引量:2
《Science China Chemistry》2020年第11期1613-1618,共6页Qingbing Wang Juan Duan Pingping Tang Gong Chen Gang He 
This work was supported by the National Natural Science Foundation of China(21672105,21725204,91753124);Natural Science Foundation of Tianjin(17JCYBJC19700,18JCZDJC32800);the Fundamental Research Funds for the Central Universities(Nankai University)(63191746).
A radical-mediated method was reported for diastereoselective synthesis of non-classical heteroaryl C-glycosides via Minisci-type alkylation of N-heteroarenes with 4-glycosyl-1,4-dihydropyridine(DHP)reagents.These DHP...
关键词:non-classical C-glycoside Minisci reaction 4-gIycosyl-dihydropyridine 
Rapid characterization of 96 chemical constituents in Citri Reticulatae Folium(leaves of ‘Fuju') using HPLC-DAD-ESI-MS^n被引量:6
《Journal of Chinese Pharmaceutical Sciences》2016年第2期91-110,共20页曹规划 付庆荣 张藏曼 王弘 陈世忠 
Beijing Natural Science Foundation(Grant No.7142088)
In order to systematically investigate the chemical constituents of Citri Reticulatae Folium (leaves of 'Fuju'), an analytical method that included high-performance liquid chromatography, diode array detection, el...
关键词:Citri Reticulatae Folium (leaves of ‘Fuju') HPLC-DAD-ESI-MS^n Flavonoid O C-GLYCOSIDES PMFs 
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