Highly Stereoselective C-Glycosylation by Photocatalytic Decarboxylative Alkynylation on Anomeric Position:A Facile Access to Alkynyl C-Glycosides  

作　　者：Kailin Lu Yingying Ma Shihui Liu Shixun Guo Yongqiang Zhang 

机构地区：[1]Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism,Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China [2]College of Medicine,Jiaxing University,Jiaxing,Zhejiang 314001,China

出　　处：《Chinese Journal of Chemistry》2022年第6期681-686,共6页中国化学（英文版）

基　　金：Financial support from the program of the National Natural Science Foundation of China(No.21871086,Y.-Q.Z.)is gratefully acknowledged.

摘　　要：The highly stereoselective synthesis of diverse medicinally valuable alkynyl C-glycosides under mild and green reaction conditions remains a great challenge.Herein,we wish to report a visible-light induced photocatalytic decarboxylative alkynylation approach.By utilizing an iridium photocatalyst in the presence of visible light,glycosyl radicals are in-situ generated via the decarboxylation of anomeric acids and efficiently coupled with a variety of ethynylbenziodoxolones(EBXs),which allows the facile synthesis of a variety of alkynyl C-glycosides in moderate to high yields and with excellent diastereoselectivity.

关 键 词：Photocatalysis Anomeric position Decarboxylative alkynylation C-C coupling GLYCOSIDES 

分 类 号：O63[理学—高分子化学]