The authors are grateful for financial support provided by NSFC(22125103and21971065);STCSM(22JC1401000,20xD1421500 and 20JC1416800);the Fundamental Research FundsfortheCentral Universities.
C-aryl glycosides are an important kind of carbohydrate derivatives for drug discovery,due to their distinctive attributes of resistance to hydrolysis from enzymes.Herein,C-aryl glycosylation was established for the s...
supported by the National Natural Science Foundation of China(Nos.22077052,21877052,21907039);the China Postdoctoral Science Foundation(2020M681487);the National Key R&D Program of China(2020YFA0908304);the Natural Science Foundation of Jiangsu Province(BK20180030,BK20190575);the National First-class Discipline Program of Light Industry Technology and Engineering(LITE2018-14);the 111 Project(111-2-06);the Open Project of Key Laboratory of Carbohydrate Chemistry and Biotechnology(Jiangnan University),Ministry of Education(KLCCB-KF202005);the Natural Science Foundation of Xuzhou(KC19154).
Most bacterial cell surface glycans are structurally unique, and have been considered as ideal target molecules for the developments of detection and diagnosis techniques, as well as vaccines. Chemical synthesis has b...
National Natural Science Foundation of China(Grant No.81930097,21977005)。
Kdo residues are widely distributed in bacteria.They are components of bacterial lipopolysaccharide(LPS)and capsular polysaccharides,which can be recognized by the human adaptive immune system,and have great potential...
A convenient and environmentally benign procedure for the synthesis of glycals from glycosyl bromides with very low zinc dust loading (1.5 equiv.) is described. The process is activated by β-cyclodextrin and ultras...
Supported by the National Natural Science Foundations of China(20475015 ,20672027)
1 Results 1,3-Dipolar cycloaddition reaction is one of the most common methods for preparing various five membered heterocycles,and provides a conveniet protocols for constructing C-C bond with functional groups.The r...
Project supported by the National Natural Science Foundation of China (No. 20475015), the Natural Science Foundation of Hebei Province (No. B2005000106), the 0pen Research Fund Program of Key Laboratory of Marine Drugs (0cean University of China), and Ministry of Education of China (No. KLMD [0UC] 200407).
Novel β-C-disaccharides containing a three carbon linkage using exo-glycal as the precursor were prepared stereoselectively. The synthesis was achieved by the tandem reactions of the stereoselective hydroboration of ...