Financial support from the NSFC(22071035);Natural Science Foundation of Guangxi(2023GXNSFDA026025);Guangxi Science and Technology Plan Project(AD23026046);Graduate Innovation Training Program of Guangxi(YCSW2024160);Natural Science Foundation of Sichuan(2023NSFSC1087);Guangxi Bagui Young Scholar is greatly appreciated.
We described a Yb(OTf)_(3) combined with Pybox ligand catalyzed asymmetric[3+3]cycloaddition of N-vinyl cinnamaldehyde nitrones with activated cyclopropanes to prepare various functionalized 1,2-oxazines in 24%—95% y...
the National Natural Science Foundation of China (No. 22071001);The Research Culture Funds of Anhui Normal University;Department of Human Resources of Anhui Province for financial support。
A novel method for HDDA-derived benzyne trapped by nitrone was developed. This research described a simple and efficient pathway for the synthesis of benzisoxazoles from arynes and PTIO(2-phenyl-4,4,5,5-tetramethylimi...
This work was supported by the Beijing Nova Program(Z201100006820049);the National Natural Science Foundation of China(No.21907109).
A nitrone-modified 1,8-naphthalimide was desig ned as a novel bioorthog on alactivated turn-on probe based on strain-promoted alkyne-nitrone cycloadditio n(SPANC).The bioorthog onal cycloadducts were subseque ntly tra...
The authors acknowledge the National Natural Science Foundation of China(nos.21971001 and 21702001);the Start-up Grant from Anhui University for financial support of this work.
A green and sustainable synthetic strategy for amide bond formation utilizing a visible light-promoted nitrone formation/rearrangement cascade was developed.This method utilized visible light as the sole and clean ene...
OBJECTIVE Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative dis⁃ease characterized by progressive loss of upper and lower motor neurons that results in skeletal muscle atrophy,weakness and paralysis.Oxida...
This work was supported by the Oklahoma Medical Research Foundation,and Oblato,Inc.,as reported in published manuscripts.
The poor prognosis of glioblastoma multiforme(GBM)patients is in part due to resistance to current standard-of-care treatments including chemotherapy[predominantly temozolomide(TMZ;Temodar)],radiation therapy and an a...
Duchenne muscular dystrophy (DMD) is a lethal X-linked recessive neuromuscular disorder caused by mutations in the dystrophin encoding gene, with the characteristics of a severe and progressive destruction of muscle s...
The compound(4-chlorophenyl)-N-(4-methylphenyl)nitrone(4CPNMPN)has been selected as one of the new nitrone derivative for our study.The molecular structure of the compound was investigated based on frontier orbital an...
Objective:Disease-modifying therapies are not available for Parkinson’s disease(PD)and several trials targeting individual pathways implicated in PD pathogenesis have failed.We hypothesize that a potentially more pow...
Financial support from the National Natural Science Foundation of China(Nos.21642012 and 21272240);National Science and Technology Major Projects for“Major New Drugs Innovation and Development”(No.2013ZX09508104);National Engineering Research Center for Carbohydrate Synthesis of Jiangxi Normal University;supported in part by a Grant-in-Aid for Scientific Research(C)(No.26460143)(AK)from the Japanese Society for the Promotion of Science(JSPS)
A series of C-7 modified analogues of casuarine have been synthesized from sugar-derived nitrone and assayed against various glycosidases. Introduction of C-7 aminomethyl or amide group led to sharp decrease of the in...