NITRONE

作品数:19被引量:5H指数:1
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相关领域:理学更多>>
相关作者:叶小翠李琳琳李沙蒋杰更多>>
相关机构:广西师范大学暨南大学更多>>
相关期刊:《Optics and Photonics Journal》《Chinese Journal of Structural Chemistry》《光谱学与光谱分析》《Chinese Journal of Chemistry》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划更多>>
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Yb(OTf)_(3)-Catalyzed Asymmetric[3+3]Cycloaddition of N-Vinyl Nitrones with Activated Cyclopropanes to Prepare 1,2-Oxazines
《Chinese Journal of Chemistry》2025年第4期417-422,共6页Yu-Zheng Wu Yue Leng Yi-Xin Chen Shi-Qiu Huang Ning Zou Chun-Hua Chen Dong-Liang Mo 
Financial support from the NSFC(22071035);Natural Science Foundation of Guangxi(2023GXNSFDA026025);Guangxi Science and Technology Plan Project(AD23026046);Graduate Innovation Training Program of Guangxi(YCSW2024160);Natural Science Foundation of Sichuan(2023NSFSC1087);Guangxi Bagui Young Scholar is greatly appreciated.
We described a Yb(OTf)_(3) combined with Pybox ligand catalyzed asymmetric[3+3]cycloaddition of N-vinyl cinnamaldehyde nitrones with activated cyclopropanes to prepare various functionalized 1,2-oxazines in 24%—95% y...
关键词:CYCLOADDITION Cyclopropane NITRONE 1 2-Oxazine Asymmetric catalysis Domino reactions Michael addition N-Heterocycle 
Benzisoxazole core and benzoxazolopyrrolidine via HDDA-derived benzyne with PTIO/DMPO
《Chinese Chemical Letters》2023年第4期318-321,共4页Yu Lei Wenjing Zhu Yajuan Zhang Qiong Hu Jie Dong Yimin Hu 
the National Natural Science Foundation of China (No. 22071001);The Research Culture Funds of Anhui Normal University;Department of Human Resources of Anhui Province for financial support。
A novel method for HDDA-derived benzyne trapped by nitrone was developed. This research described a simple and efficient pathway for the synthesis of benzisoxazoles from arynes and PTIO(2-phenyl-4,4,5,5-tetramethylimi...
关键词:Benzisoxazole HDDA reaction BENZYNE NITRONE HETEROCYCLE 
A Bioorthogonal-Activated Fluorescence Turn-On Probe Based on Nitrone-Modified 1,8-Naphthalimide for Live-Cell Imaging被引量:1
《Chinese Journal of Chemistry》2022年第2期209-214,共6页Yu Teng Hong Yang Xiang Li Yongcheng Wang Dali Yin Yulin Tian 
This work was supported by the Beijing Nova Program(Z201100006820049);the National Natural Science Foundation of China(No.21907109).
A nitrone-modified 1,8-naphthalimide was desig ned as a novel bioorthog on alactivated turn-on probe based on strain-promoted alkyne-nitrone cycloadditio n(SPANC).The bioorthog onal cycloadducts were subseque ntly tra...
关键词:Bioorthogonal reaction FLUORESCENCE NAPHTHALIMIDE Imaging agents CYCLOADDITION 
Visible Light-Promoted Amide Bond Formation via One-Pot Nitrone in Situ Formation/Rearrangement Cascade
《CCS Chemistry》2021年第11期2764-2771,共8页Bao-Gui Cai Shuai-Shuai Luo Lin Li Lei Li Jun Xuan Wen-Jing Xiao 
The authors acknowledge the National Natural Science Foundation of China(nos.21971001 and 21702001);the Start-up Grant from Anhui University for financial support of this work.
A green and sustainable synthetic strategy for amide bond formation utilizing a visible light-promoted nitrone formation/rearrangement cascade was developed.This method utilized visible light as the sole and clean ene...
关键词:AMIDES visible light CARBENE photocascade REARRANGEMENT 
TBN improves motor function and prolongs survival in SOD1G93A and TDP-43M337V mouse model of amyotrophic lateral sclerosis被引量:1
《中国药理学与毒理学杂志》2021年第9期647-648,共2页HUANG Chun-hui LI Jun ZHANG Gui-liang LIN Ying-qi LI Cai-juan ZHENG Xiao SONG Xi-cheng HAN Bo-feng GUO Bao-jian TU Zhu-chi ZHANG Jun SUN Ye-wei WANG Yu-qiang YAN Sen ZHANG Zai-jun 
OBJECTIVE Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative dis⁃ease characterized by progressive loss of upper and lower motor neurons that results in skeletal muscle atrophy,weakness and paralysis.Oxida...
关键词:amyotrophic lateral sclerosis tetra⁃methylpyrazine nitrone superoxide dismutase 1 
Novel approaches to combat chemoresistance against glioblastomas被引量:2
《Cancer Drug Resistance》2020年第4期686-698,共13页Rheal A.Towner Michelle Zalles Debra Saunders Nataliya Smith 
This work was supported by the Oklahoma Medical Research Foundation,and Oblato,Inc.,as reported in published manuscripts.
The poor prognosis of glioblastoma multiforme(GBM)patients is in part due to resistance to current standard-of-care treatments including chemotherapy[predominantly temozolomide(TMZ;Temodar)],radiation therapy and an a...
关键词:GLIOBLASTOMA pre-clinical models OKlahoma Nitrone 007 transforming growth factor-β1 ELTD1 magnetic resonance imaging 
Tetramethylpyrazine Nitrone Improved Motor Deficits and Alleviated Dystrophic Muscle Pathology in the <i>mdx</i>Mouse Model of Duchenne Muscular Dystrophy
《Journal of Biosciences and Medicines》2020年第8期56-66,共11页Fengjiao Wang Jing Wen Guiliang Zhang Zheng Liu Haijing Zhong Gaoxiao Zhang Yewei Sun Pei Yu Yuqiang Wang Zaijun Zhang 
Duchenne muscular dystrophy (DMD) is a lethal X-linked recessive neuromuscular disorder caused by mutations in the dystrophin encoding gene, with the characteristics of a severe and progressive destruction of muscle s...
关键词:Duchenne Muscular Dystrophy Fibrosis DYSFERLIN TBN mdx Mouse 
Quantum Chemical and Corrosion Inhibition Studies of (4-Chlorophenyl)-N-(4-Methylphenyl) Nitrone
《光谱学与光谱分析》2019年第12期3940-3945,共6页Rubarani.P.Gangadharan S.Sampath Krishnan M.Thirumalaikumar 
The compound(4-chlorophenyl)-N-(4-methylphenyl)nitrone(4CPNMPN)has been selected as one of the new nitrone derivative for our study.The molecular structure of the compound was investigated based on frontier orbital an...
关键词:MOLECULAR ORBITAL ANALYSIS Corrosion INHIBITION NBO ANALYSIS 
NP-20 Tetramethylpyrazine Nitrone Activates PGC-1α/Nrf2 Pathway to Prevent Neurodegeneration in Experimental Models of Parkinson’s Disease
《神经药理学报》2018年第4期117-118,共2页ZHANG Zai-jun GUO Bao-jian ZHENG Cheng-you WANG Yu-qiang 
Objective:Disease-modifying therapies are not available for Parkinson’s disease(PD)and several trials targeting individual pathways implicated in PD pathogenesis have failed.We hypothesize that a potentially more pow...
关键词:Experimental PGC-1Α treatment Α-SYNUCLEIN multiple expression strategy effects 
Synthesis and glycosidase inhibition of C-7 modified casuarine derivatives
《Chinese Chemical Letters》2017年第8期1701-1704,共4页Bin Cheng Yuki Hirokami Yi-Xian Li Atsushi Kato Yue-Mei Jia Chu-Yi Yu 
Financial support from the National Natural Science Foundation of China(Nos.21642012 and 21272240);National Science and Technology Major Projects for“Major New Drugs Innovation and Development”(No.2013ZX09508104);National Engineering Research Center for Carbohydrate Synthesis of Jiangxi Normal University;supported in part by a Grant-in-Aid for Scientific Research(C)(No.26460143)(AK)from the Japanese Society for the Promotion of Science(JSPS)
A series of C-7 modified analogues of casuarine have been synthesized from sugar-derived nitrone and assayed against various glycosidases. Introduction of C-7 aminomethyl or amide group led to sharp decrease of the in...
关键词:Nitrone 1.3-Dipolar cycloaddition Ammonolysis Glycosidase inhibitors Polyhydroxylated pyrrolizidines 
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