C-Glycoside Synthesis Enabled by Nickel Catalysis  

作　　者：Weidong Shang Rong Shi Dawen Niu 

机构地区：[1]Targeted Tracer Research and Development Laboratory,Institute of Respiratory Health,State Key Laboratory of Biotherapy and Cancer Center West China Hospital and Schoolof Chemical Engineering,Sichuan University,Chengdu,Sichuan 610041,China [2]State Key Laboratory of Biotherapy and Cancer Center,West China Hospital and Department of Chemical Engineering,Sichuan University,Chengdu,Sichuan 610041,China

出　　处：《Chinese Journal of Chemistry》2023年第17期2217-2236,共20页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(21907071,21922106,and T2221004);Fok Ying Tung Education Foundation for financial support.

摘　　要：Comprehensive Summary,C-Glycosides are critical,naturally occurring products and medicinal candidates,and extensive efforts have been made to explore efficient approaches for creating C-glycosidic bonds.Transition-metal-catalysis,particularly nickel-catalyzed C-glycosylation reactions constitute a promising strategy.However,achieving a stereoselective synthesis ofα-andβ-C-glycosides has been a long-standing challenge.To address this problem,a variety of nickel-mediated strategies have been developed.This review highlights recent developments in the nickel-catalyzed diastereoselective C-glycosylation reactions and briefly summarizes the mechanistic understandings of these methods.

关 键 词：C-GLYCOSIDES NICKEL GLYCOSYLATION Glycosyl radical Carbohydrates 

分 类 号：O63[理学—高分子化学]