GLYCOPEPTIDE

作品数：35被引量：32H指数：3
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相关领域：医药卫生生物学更多>>
相关作者：刘永强王岩周秋丽池岛乔杨明更多>>
相关机构：长春中医学院吉林省中医中药研究所吉林大学北京大学更多>>
相关期刊：《International Journal of Ophthalmology(English edition)》《中国感染与化疗杂志》《Precision Medicine Research》《Chemical Research in Chinese Universities》更多>>
相关基金：国家自然科学基金天津市自然科学基金国家重点基础研究发展计划更多>>
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Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation
《National Science Review》2024年第11期142-153,共12页Yingying Xiong Zhuoer Lu Yuyin Shao Peiyi Meng Guoli Wang Xinwen Zhou Jun Yao Huimin Bao Haojie Lu 
supported by the National Key Research and Development Program of China(2023YFF1205900);the National Natural Science Foundation of China(22434001 and 82121004);the Shanghai Science and Technology Program(2023SHZDZX02,22DZ2291700 and 22142202400).
Protein glycosylation,the most universal post-translational modification,is thought to play a crucial role in regulating multiple essential cellular processes.However,the low abundance of glycoproteins and the heterog...
关键词：GLYCOPROTEOMICS large-scale enrichment O-GLCNACYLATION N-GLYCOSYLATION oxidative stress 
Lycium barbarum glycopeptide(wolfberry extract)slows N-methyl-N-nitrosourea-induced degradation of photoreceptors被引量：1
《Neural Regeneration Research》2024年第10期2290-2298,共9页Qihang Kong Xiu Han Haiyang Cheng Jiayu Liu Huijun Zhang Tangrong Dong Jiansu Chen Kwok-Fai So Xuesong Mi Ying Xu Shibo Tang 
supported by Guangzhou Key Projects of Brain Science and Brain-Like Intelligence Technology,No.20200730009 (to YX);the National Natural Science Foundation of China,No.82074169 (to XM);the Guangdong Basic and Applied Basic Research Foundation,No.2021A1515012473 (to XM);Project of Administration of Traditional Chinese Medicine of Guangdong Province,No.20202045 (to XM);Aier Eye Hospital Group,No.AF2019001 (to ST,KFS,YX,XM)。
Photoreceptor cell degeneration leads to blindness, for which there is currently no effective treatment. Our previous studies have shown that Lycium barbarum(L. barbarum) polysaccharide(LBP) protects degenerated photo...
关键词：anti-inflammation inherited retinal diseases Lycium barbarum glycopeptide N-METHYL-N-NITROSOUREA OPSIN photoreceptor reactive gliosis retinal degeneration retinitis pigmentosa RHODOPSIN 
Retinal ischemia-reperfusion injury and pretreatment with Lycium barbarum glycopeptide
《International Journal of Ophthalmology(English edition)》2024年第9期1599-1605,共7页Yan-Xia Wu Shuo Yin Shan-Shan Song Xiang Liu Yu-Xuan Deng Xue-Jing Lu 
Supported by the National Natural Science Foundation of China(No.82174444);the Chengdu University of Traditional Chinese Medicine Xinglin Scholar Discipline Talent Research Promotion Program Project(No.XKTD2022009);the Inheritance and Communication Department of Science and Technology Innovation Engineering Department of Chinese Academy of Chinese Medical Sciences(No.XJ2023001701).
AIM:To investigate the antioxidant protective effect of Lycium barbarum glycopeptide(LbGP)pretreatment on retinal ischemia-reperfusion(I/R)injury(RIRI)in rats.METHODS:RIRI was induced in Sprague Dawley rats through an...
关键词：retinal ischemia-reperfusion Lycium barbarum glycopeptide PRETREATMENT ANTI-INFLAMMATORY ANTIOXIDATIVE RAT 
Glyco-signatures in patients with advanced lung cancer during anti-PD-1/PD-L1 immunotherapy被引量：1
《Acta Biochimica et Biophysica Sinica》2024年第8期1099-1107,共9页Xinyi Cao Zhihuang Hu Xiangying Sheng Zhenyu Sun Lijun Yang Hong Shu Xiaojing Liu Guoquan Yan Lei Zhang Chao Liu Ying Zhang Huijie Wang Haojie Lu 
supported by the grants from the National Key Research and Development Program of China(No.2022YFC3400800);the National Natural Science Foundation of China(Nos.21974025 and 82121004);the Shanghai Projects(Nos.22142202400 and 22DZ2291700);the Greater Bay Area Institute of Precision Medicine(No.IPM2021C005).
Immune checkpoint inhibitors(ICIs)targeting programmed cell death 1/programmed cell death ligand-1(PD-1/PDL1)have significantly prolonged the survival of advanced/metastatic patients with lung cancer.However,only a sm...
关键词：lung cancer PD-1/PD-L1 IMMUNOTHERAPY GLYCOPEPTIDE IGG 
Cartilage-inspired self-assembly glycopeptide hydrogels for cartilage regeneration via ROS scavenging被引量：1
《Bioactive Materials》2024年第2期319-332,共14页Zhijian Zhao Xiaowei Xia Junlin Liu Mingzhuang Hou Yang Liu Zhangzhe Zhou Yong Xu Fan He Huilin Yang Yijian Zhang Changshun Ruan Xuesong Zhu 
supported by grants from National Key R&D Program of China(Grant Nos:2022YFC2502902);National Natural Science Foundation of China(Grant Nos:82072442,82272494,82072082 and 32122046);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);the Shenzhen Fundamental Research Foundation(Grant Nos.JCYJ20210324115814040 and JCYJ20210324113001005).
Cartilage injury represents a frequent dilemma in clinical practice owing to its inherently limited self-renewal capacity.Biomimetic strategy-based engineered biomaterial,capable of coordinated regulation for cellular...
关键词：Cartilage repair Self-assembly glycopeptide hydrogels FUCOIDAN ROS scavenging 
Hematoma-like dynamic hydrogelation through natural glycopeptide molecular recognition for infected bone fracture repair
《Bioactive Materials》2023年第12期73-84,共12页Shenghao Wang Wenbo He Huan Wang Dachuan Liu Miao Wang Huilin Yang Guoqing Pan Bin Li 
the National Natural Science Foundation of China(32222041,82102619,81925027,21875092);the Natural Science Foundation of Jiangsu Province(BK20220059);the National Key Research and Development Program of China(2019YFA0112000)。
Infected bone fractures remain a major clinical challenge for orthopedic surgeons.From a tissue regeneration perspective,biomaterial scaffolds with antibacterial and osteoinductive activities are highly desired,while ...
关键词：Dynamic biomaterial Molecular recognition Hematoma mimicking Infected fracture repair Inflammatory microenvironment restoration 
Efficient Coupling of Complex Fluorooligosaccharides to Phenolic Peptide Mediated by Calcium Iodide
《Chinese Journal of Chemistry》2023年第19期2483-2487,共5页Pei Liu Xing Quan Fangyu Wei Xianjun Deng Jie Shen Jiansong Cheng 
support from the National Key R&D Program of China(2018YFE0200501);the National Natu-ral Science Foundation of China(21977055).
Besides serving as therapeutic agents and building blocks for glycoprotein synthesis,homogeneous synthetic glycopeptides also benefit understanding function of specific glycoform.However,the selectivity coupling of ol...
关键词：Calcium iodide α-Fluoroglycoside GLYCOSYLATION COUPLING GLYCOPEPTIDE 
Insights on the molecular mechanism of neuroprotection exerted by edible bird’s nest and its bioactive constituents
《Food Science and Human Wellness》2023年第4期1008-1019,共12页Weiyi Chu Chia Wei Phan Seng Joe Lim Abdul Salam Babji 
supported by the Research Excellence Consortium(KKP/2020/UKM-UKM/5/1)provided by Ministry of Higher Education,Malaysia;supported by the Fundamental Research Grant Scheme(FRGS),Project No.FP016-2019A,Reference Code:FRGS/1/2019/SKK09/UM/02/2.
Neurodegenerative diseases are often associated with the accumulation of oxidative stress and neuroinflammation.Edible bird’s nest(EBN)is a glycoprotein(sialylated mucin glycopeptides)found to be beneficial against n...
关键词：Antioxidant Composition Edible bird nest Neurodegenerative disease NEUROPROTECTION Sialylated mucin glycopeptide 
Recent Advances in Glycopeptide and Glycoprotein Synthesis:A Refined Synthetic Probe towards the Biological World被引量：1
《Chinese Journal of Chemistry》2023年第16期2010-2024,共15页Haoru Zhuang Huiran Hao Yongshun Qiu Jinjuan Gan Tianlu Li 
Shenzhen Fundamental Research Program(RCBS20200714114957255);the National Natural Science Foundation of China(Grant No.22177061);the National Key Research and Development Program of China(2018YFA0902000);the Open Projects Fund of Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology(2021CCG01).
Comprehensive Summary Protein glycosylation is the most complex and diverse form of post-translational modification in human body.Meanwhile,glycosylation of peptides and proteins emerges as a promising strategy to imp...
关键词：GLYCOPROTEINS GLYCOPEPTIDES GLYCOSYLATION Total synthesis BIOSYNTHESIS Structure-activity relationships 
Synthesis and immunological evaluation of Mincle ligands-based antitumor vaccines
《Chinese Chemical Letters》2023年第7期141-145,共5页Kun Wang Tong Zhang Mingyang Liu Danyang Wang Haomiao Zhu Zhaoyu Wang Fan Yu Yonghui Liu Wei Zhao 
supported by the National Natural Science Foundation of China (Nos. 22077068, 82103984);the Fundamental Research Funds for the Central Universities。
The development of novel adjuvants constitutes a new strategy for the research of tumor vaccines.Immunomodulatory molecule adjuvants are one of the novel adjuvants that can effectively stimulate the pattern recognitio...
关键词：Cancer vaccine MUC1 antigen Mincle ligand GLYCOPEPTIDE Vaccine ligand 
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