机构地区:[1]Department of Ophthalmology,Aier Eye Hospital,Jinan University,Guangzhou,Guangdong Province,China [2]Department of Ophthalmology,The First Affiliated Hospital of Jinan University,Guangzhou,Guangdong Province,China [3]Guangdong-Hong Kong-Macao Institute of CNS Regeneration,Key Laboratory of CNS Regeneration(Ministry of Education),Jinan University,Guangzhou,Guangdong Province,China [4]Department of Ophthalmology,Guangzhou Panyu Central Hospital,Guangzhou,Guangdong Province,China [5]School of Stomatology,Jinan University,Guangzhou,Guangdong Province,China [6]Aier Academician Station,Changsha,Hunan Province,China [7]Co-Innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China [8]State Key Laboratory of Brain and Cognitive Sciences,Hong Kong Special Administrative Region,China
出 处:《Neural Regeneration Research》2024年第10期2290-2298,共9页中国神经再生研究(英文版)
基 金:supported by Guangzhou Key Projects of Brain Science and Brain-Like Intelligence Technology,No.20200730009 (to YX);the National Natural Science Foundation of China,No.82074169 (to XM);the Guangdong Basic and Applied Basic Research Foundation,No.2021A1515012473 (to XM);Project of Administration of Traditional Chinese Medicine of Guangdong Province,No.20202045 (to XM);Aier Eye Hospital Group,No.AF2019001 (to ST,KFS,YX,XM)。
摘 要:Photoreceptor cell degeneration leads to blindness, for which there is currently no effective treatment. Our previous studies have shown that Lycium barbarum(L. barbarum) polysaccharide(LBP) protects degenerated photoreceptors in rd1, a transgenic mouse model of retinitis pigmentosa. L. barbarum glycopeptide(Lb GP) is an immunoreactive glycoprotein extracted from LBP. In this study, we investigated the potential protective effect of Lb GP on a chemically induced photoreceptor-degenerative mouse model. Wild-type mice received the following: oral administration of Lb GP as a protective pre-treatment on days 1–7;intraperitoneal administration of 40 mg/kg N-methylN-nitrosourea to induce photoreceptor injury on day 7;and continuation of orally administered Lb GP on days 8–14. Treatment with Lb GP increased photoreceptor survival and improved the structure of photoreceptors, retinal photoresponse, and visual behaviors of mice with photoreceptor degeneration. Lb GP was also found to partially inhibit the activation of microglia in N-methyl-N-nitrosourea-injured retinas and significantly decreased the expression of two pro-inflammatory cytokines. In conclusion, Lb GP effectively slowed the rate of photoreceptor degeneration in N-methyl-N-nitrosourea-injured mice, possibly through an anti-inflammatory mechanism, and has potential as a candidate drug for the clinical treatment of photoreceptor degeneration.
关 键 词:anti-inflammation inherited retinal diseases Lycium barbarum glycopeptide N-METHYL-N-NITROSOUREA OPSIN photoreceptor reactive gliosis retinal degeneration retinitis pigmentosa RHODOPSIN
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