N-METHYL-N-NITROSOUREA

作品数：9被引量：10H指数：2
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相关领域：医药卫生更多>>
相关作者：王克岩汪巨峰徐格致吕建军李芊芊更多>>
相关机构：复旦大学中国食品药品检定研究院更多>>
相关期刊：《癌变．畸变．突变》《World Journal of Gastroenterology》《Advances in Biological Chemistry》《International Journal of Ophthalmology(English edition)》更多>>
相关基金：国家自然科学基金更多>>
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Lycium barbarum glycopeptide(wolfberry extract)slows N-methyl-N-nitrosourea-induced degradation of photoreceptors被引量：1
《Neural Regeneration Research》2024年第10期2290-2298,共9页Qihang Kong Xiu Han Haiyang Cheng Jiayu Liu Huijun Zhang Tangrong Dong Jiansu Chen Kwok-Fai So Xuesong Mi Ying Xu Shibo Tang 
supported by Guangzhou Key Projects of Brain Science and Brain-Like Intelligence Technology,No.20200730009 (to YX);the National Natural Science Foundation of China,No.82074169 (to XM);the Guangdong Basic and Applied Basic Research Foundation,No.2021A1515012473 (to XM);Project of Administration of Traditional Chinese Medicine of Guangdong Province,No.20202045 (to XM);Aier Eye Hospital Group,No.AF2019001 (to ST,KFS,YX,XM)。
Photoreceptor cell degeneration leads to blindness, for which there is currently no effective treatment. Our previous studies have shown that Lycium barbarum(L. barbarum) polysaccharide(LBP) protects degenerated photo...
关键词：anti-inflammation inherited retinal diseases Lycium barbarum glycopeptide N-METHYL-N-NITROSOUREA OPSIN photoreceptor reactive gliosis retinal degeneration retinitis pigmentosa RHODOPSIN 
The reason for the amelioration of N-methyl-N-nitrosourea-induced retinitis pigmentosa in rats by hydrogen-rich saline被引量：2
《International Journal of Ophthalmology(English edition)》2017年第10期1495-1503,共9页Wei-Ming Yan Tao Chen Xiao-Cheng Wang Lin-Song Qi Guan-Hua Zhao Guo-Qing Yang Yi-Fei Ma Ye Tao Lei Zhang Zuo-Ming Zhang 
Supported by the Natural Science Foundation of China(No.81300836);the Foundation of Open Sharing Platform of Science and Technology of Shaanxi Province,China(No.2015FWPT-02)
AIM：To investigate the effects of hydrogen-rich saline（HRS）on microglia activation and Sirtuin type 1（Sirt1）in rats with N-methyl-N-nitrosourea（MNU）-induced retinitis pigmentosa（RP）.METHODS：Rats were divided...
关键词：HYDROGEN hydrogen-rich saline ELECTRORETINOGRAM microglia Sirtl retinitis pigmentosa 
Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice被引量：3
《World Journal of Gastroenterology》2017年第23期4233-4242,共10页shan zhuang yong-mei jian yong-ning sun 
AIM To investigate the inhibitory effect of Liuwei Dihuang Pill(LDP) on gastric tumorigenesis induced by N-methyl-N-nitrosourea(MNU) in diabetic mice.METHODS Four-week-old mice were divided into four groups: A, 12 db/...
关键词：DIABETES Gastric cancer Liuwei Dihuang Pill INSULIN Insulin-like growth factor 
HSP70 cleavage-induced photoreceptor cell death caused by N-methyl-N-nitrosourea
《Neural Regeneration Research》2016年第11期1758-1759,共2页Yoshiki Koriyama Ayako Furukawa 
Retinal degenerative diseases （RDs） such as retinitis pigmentosa （RP） are characterized by slowly progressive photoreceptor cell death, but the molecular mechanism underlying RP remains unclear. Animal models for ...
关键词：HSP70 cleavage-induced photoreceptor cell death caused by N-methyl-N-nitrosourea cell MNU 
Protective effects of naringenin eye drops on N-methylN-nitrosourea-induced photoreceptor cell death in rats被引量：1
《International Journal of Ophthalmology(English edition)》2014年第3期391-396,共6页Jun-Li Lin Yan-Dong Wang Yan Ma Chun-Mei Zhong Mei-Rong Zhu Wen-Pei Chen Bao-Qin Lin 
Supported by Guangdong Provincial Department of Science and Technology Grant(No.2011B031700052)
AIM:To investigate the effects of naringenin eye drops on N-methyl-N-nitrosourea (MNU)-induced photoreceptor cell death in rats.METHODS:Photoreceptor cell death was induced by single intraperitoneal injection of MNU(6...
关键词：NARINGENIN N-METHYL-N-NITROSOUREA photoreceptor cell death retinitis pigmentosa 
Suppression of <i>N</i>-Methyl-<i>N</i>-Nitrosourea-Induced Retinal Damage in Mice by Oligonol, an Oligomerized Polyphenol Formulation
《Advances in Biological Chemistry》2014年第2期138-147,共10页Jun Kisugi Miwako Nasui Koji Wakame Jun Takanari Masatoshi Yamazaki Satoru Yui 
Oligonol is a lychee fruit-derived functional food that contains oligomerized polyphenol compounds. Oligonol exhibits a number of beneficial biological effects, primarily due to its antioxidant activity. Retinitis pig...
关键词：Oligonol Oligomerized Polyphenols RETINITIS Pigmentosa N-METHYL-N-NITROSOUREA RETINAL Degeneration Antioxidant 
N-methyl-N-nitrosourea-induced apoptosis of photoreceptor cells in Sprague-Dawley rats via nuclear factor-κB被引量：2
《Chinese Medical Journal》2005年第13期1081-1086,共6页YANGJin-nan LUOLin LINShao-chun CHENJin-mao LIDai HUShi-xing 
ThisstudywassupportedbyagrantfromtheNationalNaturalScienceFoundationofChina(No 30300467)
Background Previous studies have showed that photooxidative stress can leadto down-modulation of nuclear factor-κappa B ( NF-κB ) activity causing apoptosis of culturedphotoreceptor cells. This study aimed at invest...
关键词：METHYLNITROSOUREA PHOTORECEPTORS APOPTOSIS nuclear factor-kappa B 
QUALITATIVE　STUDY　OF　SIALOMUCINS　CHANGES　DURING　N－METHYL－N－NITROSOUREA－INDUCED　C　OLONIC　CARCINOGENESIS　IN　MICE
《Chinese Journal of Cancer Research》1994年第4期235-240,共6页王强 王元和 高瀚 陈咏莲 何金 
The sequential histological and sialomucins histochemical changes in colonic epithelium during the N-methyl-N-nitrosourea (MNU) induced colonic carcinogenesis were studied in female ICR mice. The sialomucin histochemi...
关键词：Experimental colonic neoplasm Sialomucin Mucin histochemistry. 
ANALYSIS OF N-METHYL-N-NITROSOUREA-INDUCED MUTATIONS IN A SHUTTLE VECTOR PLASMID PROPAGATED IN MOUSE O^6-METHYLGUANINE-DNA METHYLTRANSFERASE-DEFICIENT CELLS IN COMPARISON WITH PROFICIENT CELLS.被引量：1
《癌变．畸变．突变》1991年第S1期132-132,共1页Shin-ichiMoriwaki TakashiYagi ChikakoNishigori HirakuTakebe 
To investigate a contribution of O-methylguanineto mutagenesis in mouse cells,we constructed ashuttle vector plasmid,pYZ289,from a part ofpZ189 plasmid and polyoma virus DNA.The plasmidcontains a supF gene as a marker...
关键词：PLASMID mutagenesis DNA PURINE marker mutation mutated GUANINE methy shuttle 
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