supported by Guangzhou Key Projects of Brain Science and Brain-Like Intelligence Technology,No.20200730009 (to YX);the National Natural Science Foundation of China,No.82074169 (to XM);the Guangdong Basic and Applied Basic Research Foundation,No.2021A1515012473 (to XM);Project of Administration of Traditional Chinese Medicine of Guangdong Province,No.20202045 (to XM);Aier Eye Hospital Group,No.AF2019001 (to ST,KFS,YX,XM)。
Photoreceptor cell degeneration leads to blindness, for which there is currently no effective treatment. Our previous studies have shown that Lycium barbarum(L. barbarum) polysaccharide(LBP) protects degenerated photo...
supported in part by JSPS KAKENHI Grant Numbers in Japan(JP21H05229 to I.K.);JST CREST(JPMJCR21B2);The authors also thank Nobuko Yamaguchi for the financial support.
Rhodopsin is a seven-helical transmembrane protein with a retinal chromophore covalently bound to a conserved lysine in helix G via a retinal protonated Schiff base(RPSB).Microbial rhodopsins absorb light through chro...
supported by The National Natural Science Foundation of China(No.82121003,81970841,82101160);the program of Science and Technology International Cooperation Project of Qinghai province(China)(No.2022-HZ-814);the CAMS Innovation Fund for Medical Sciences(No.2019-12M-5-032);Sichuan Intellectual Property Office(China)(No.2022-ZS-0070);the Department of Chengdu Science and Technology(Sichuan,China)(No.2021-YF05-01316-SN).
The endoplasmic reticulum(ER)membrane protein complex(EMC)is responsible for monitoring the biogenesis and synthetic quality of membrane proteins with tail-anchored or multiple transmembrane domains.The EMC subunit EM...
supported by the Project No.191986,Fronteras de la Ciencia-CONACyT;Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica(PAPIIT),UNAM No.IN212419。
Cave-adapted animals provide a unique opportunity to study the evolutionary mechanisms underlying phenotypic,metabolic,behavioral,and genetic evolution in response to cave environments.The Mexican tetra(Astyanax mexic...
supported by the National Key Research and Development Program of China(No.2018YFC0309904);the National Natural Science Foundation of China(Nos.91751202,41806174,91751108);the Key Research and Development Program of Hainan Province(No.ZDKJ2019011);Grant Y9719105 from the Institute of Deep-sea Technology Innovation,Chinese Academy of Sciences(IDSTI-CAS);Grant 2019YD16 from Sanya City and Grant INSB-DBM2021;support to LIA-MagMC from Centre National de la Recherche Scientifique.
Deep-sea hydrothermal vents are known as chemosynthetic ecosystems.However,high temperature vents emit light that hypothetically can drive photosynthesis in this habitat.Metagenomic studies have sporadically reported ...
This work was supported by National Key R&D Program of China(2017YFE0103400)to Y.S.;National Nature Science Foundation of China(81900874)to Y.C.,Macao Science and Technology Development Fund to Kang Zhang(0007/2020/AFJ);the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)Projektnummer 374031971 TRR 240 A04 and DFG Projektnummer 417451587 to G.N.
Inherited and age-related retinal degenerative diseases cause progressive loss of photoreceptors,ultimately leading to blindness.Optogenetics is a promising strategy for restoring visual function through photosensitiv...
the National Key Research and Development Program of China(2020YFA0112200,2016YFA0400900,and 2018YFA0801403);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16020603,XDB39000000,and XDB32060200);the National Natural Science Foundation of China(81925009,81790644,61890953,31322024,81371066,91432104,81900855,31900712,and 31800901);Guangdong Provincial Key Research and Development Program(2019B030335001 and 2018B030338001);Anhui Provincial Natural Science Foundation(1808085MH289 and 1908085MC66);the Fundamental Research Funds for the Central Universities(WK2070000174 and WK2090050048)。
Retinitis pigmentosa(RP)is a form of inherited retinal degenerative diseases that ultimately involves the macula,which is present in primates but not in the rodents.Therefore,creating nonhuman primate(NHP)models of RP...
The work was supported by the National Key Research and Development Program Grant(No.2017YFC1404302);Natural Science Foundation of China Grants NSFC(Nos.31661143029 and 41776116).
Rhodopsins are now found in all domains of life,and are classified into two large groups:type II,found in animals and type I found in microbes including Bacteria,Archaea,and Eukarya.While type II rhodopsin functions i...
supported by the National Natural Science Foundation of China(No.41706137);the Natural Science Foundation of Guangdong Province in China(No.2017A030310332)
The regeneration rates of rhodopsin under weak and bright light are stimulated, and a model of three energy levels is founded to simulate the photocycle and regeneration rhodopsin when rhodopsin is illuminated by weak...