RHODOPSIN

作品数:30被引量:32H指数:3
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相关领域:医药卫生生物学更多>>
相关作者:刘畅王薇俞海燕张纯吴文涛更多>>
相关机构:北京大学第三医院苏州大学中山大学中国科学院更多>>
相关期刊:《Signal Transduction and Targeted Therapy》《Chinese Physics Letters》《生物化学与生物物理进展》《Magnetic Resonance Letters》更多>>
相关基金:国家自然科学基金国家教育部博士点基金北京市科委基金湖北省自然科学基金更多>>
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Lycium barbarum glycopeptide(wolfberry extract)slows N-methyl-N-nitrosourea-induced degradation of photoreceptors被引量:1
《Neural Regeneration Research》2024年第10期2290-2298,共9页Qihang Kong Xiu Han Haiyang Cheng Jiayu Liu Huijun Zhang Tangrong Dong Jiansu Chen Kwok-Fai So Xuesong Mi Ying Xu Shibo Tang 
supported by Guangzhou Key Projects of Brain Science and Brain-Like Intelligence Technology,No.20200730009 (to YX);the National Natural Science Foundation of China,No.82074169 (to XM);the Guangdong Basic and Applied Basic Research Foundation,No.2021A1515012473 (to XM);Project of Administration of Traditional Chinese Medicine of Guangdong Province,No.20202045 (to XM);Aier Eye Hospital Group,No.AF2019001 (to ST,KFS,YX,XM)。
Photoreceptor cell degeneration leads to blindness, for which there is currently no effective treatment. Our previous studies have shown that Lycium barbarum(L. barbarum) polysaccharide(LBP) protects degenerated photo...
关键词:anti-inflammation inherited retinal diseases Lycium barbarum glycopeptide N-METHYL-N-NITROSOUREA OPSIN photoreceptor reactive gliosis retinal degeneration retinitis pigmentosa RHODOPSIN 
Solid-state NMR of the retinal protonated Schiff base in microbial rhodopsins
《Magnetic Resonance Letters》2024年第3期11-18,共8页Sari Kumagai Izuru Kawamura 
supported in part by JSPS KAKENHI Grant Numbers in Japan(JP21H05229 to I.K.);JST CREST(JPMJCR21B2);The authors also thank Nobuko Yamaguchi for the financial support.
Rhodopsin is a seven-helical transmembrane protein with a retinal chromophore covalently bound to a conserved lysine in helix G via a retinal protonated Schiff base(RPSB).Microbial rhodopsins absorb light through chro...
关键词:Membrane proteins Microbial rhodopsin RETINAL Solid-state NMR Protonated Schiff base 
The endoplasmic reticulum membrane protein complex subunit Emc6 is essential for rhodopsin localization and photoreceptor cell survival
《Genes & Diseases》2024年第2期1035-1049,共15页Kuanxiang Sun Lu Liu Xiaoyan Jiang Heting Wang Lin Wang Yeming Yang Wenjing Liu Lin Zhang Xiaohui Zhao Xianjun Zhu 
supported by The National Natural Science Foundation of China(No.82121003,81970841,82101160);the program of Science and Technology International Cooperation Project of Qinghai province(China)(No.2022-HZ-814);the CAMS Innovation Fund for Medical Sciences(No.2019-12M-5-032);Sichuan Intellectual Property Office(China)(No.2022-ZS-0070);the Department of Chengdu Science and Technology(Sichuan,China)(No.2021-YF05-01316-SN).
The endoplasmic reticulum(ER)membrane protein complex(EMC)is responsible for monitoring the biogenesis and synthetic quality of membrane proteins with tail-anchored or multiple transmembrane domains.The EMC subunit EM...
关键词:ANO2 CILIUM EMC6 ER membrane protein complex Mislocalization Photoreceptor degeneration TMEM67 
普通大蓟马MuRhodopsin基因的全长克隆及生物信息学分析被引量:3
《热带生物学报》2023年第6期651-659,共9页金海峰 王朝政 侯清芳 咸利民 张华剑 吴少英 
三亚崖州湾科技城管理局资助项目(SYND-2021-21,HNF202202);海南省重大科技计划项目(ZDKJ2021007)。
为了解蓟马害虫视蛋白分子结构及特征,根据普通大蓟马(Megalurothrips usitatus)转录组信息克隆获得了视紫红质MuRhodopsin的基因cDNA全长,并利用DNAMan 9.0和SWISSMODEL等软件对视紫红质MuRhodopsin的基因进行序列同源性比对并构建基...
关键词:普通大蓟马 Rhodopsin基因 视蛋白 序列分析 结构预测 
Mitochondrial phylogeography and molecular evolution of the rhodopsin visual pigment in troglobitic populations of Astyanax mexicanus(De Filippi,1853)
《Zoological Research》2023年第4期761-775,共15页Marco A.A.Garduño-Sánchez Vladimir de Jesus-Bonilla Silvia Perea Ramses Miranda-Gamboa Andrea Herrera-García Mauricio de la Maza Benignos Claudia Patricia Ornelas-García 
supported by the Project No.191986,Fronteras de la Ciencia-CONACyT;Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica(PAPIIT),UNAM No.IN212419。
Cave-adapted animals provide a unique opportunity to study the evolutionary mechanisms underlying phenotypic,metabolic,behavioral,and genetic evolution in response to cave environments.The Mexican tetra(Astyanax mexic...
关键词:Visual pigments Selection CAVEFISH Vision loss Loss of function 
Metagenomic analysis reveals wide distribution of phototrophic bacteria in hydrothermal vents on the ultraslow-spreading Southwest Indian Ridge
《Marine Life Science & Technology》2022年第2期255-267,共13页Hong Chen Deng Hui Li Ai Jun Jiang Xue Gong Li Shi Jun Wu Jian Wei Chen Meng Jie Qu Xiao Qing Qi Jie Dai Rui Zhao Wei-Jia Zhang Shan Shan Liu Long-Fei Wu 
supported by the National Key Research and Development Program of China(No.2018YFC0309904);the National Natural Science Foundation of China(Nos.91751202,41806174,91751108);the Key Research and Development Program of Hainan Province(No.ZDKJ2019011);Grant Y9719105 from the Institute of Deep-sea Technology Innovation,Chinese Academy of Sciences(IDSTI-CAS);Grant 2019YD16 from Sanya City and Grant INSB-DBM2021;support to LIA-MagMC from Centre National de la Recherche Scientifique.
Deep-sea hydrothermal vents are known as chemosynthetic ecosystems.However,high temperature vents emit light that hypothetically can drive photosynthesis in this habitat.Metagenomic studies have sporadically reported ...
关键词:CHLOROPHYLL RHODOPSIN Phototrophic bacteria Hydrothermal vent Southwest Indian Ridge 
Visual function restoration with a highly sensitive and fast Channelrhodopsin in blind mice被引量:1
《Signal Transduction and Targeted Therapy》2022年第5期1389-1391,共3页Fei Chen Xiaodong Duan Yao Yu Shang Yang Yuanyuan Chen Christine EGee Georg Nagel Kang Zhang Shiqiang Gao Yin Shen 
This work was supported by National Key R&D Program of China(2017YFE0103400)to Y.S.;National Nature Science Foundation of China(81900874)to Y.C.,Macao Science and Technology Development Fund to Kang Zhang(0007/2020/AFJ);the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)Projektnummer 374031971 TRR 240 A04 and DFG Projektnummer 417451587 to G.N.
Inherited and age-related retinal degenerative diseases cause progressive loss of photoreceptors,ultimately leading to blindness.Optogenetics is a promising strategy for restoring visual function through photosensitiv...
关键词:VISUAL VISUAL function 
Generation of nonhuman primate retinitis pigmentosa model by in situ knockout of RHO in rhesus macaque retina被引量:4
《Science Bulletin》2021年第4期374-385,M0004,共13页Shouzhen Li Yingzhou Hu Yunqin Li Min Hu Wenchao Wang Yuqian Ma Yuan Cai Min Wei Yichuan Yao Yun Wang Kai Dong Yonghao Gu Huan Zhao Jin Bao Zilong Qiu Mei Zhanga Xintian Hu Tian Xue 
the National Key Research and Development Program of China(2020YFA0112200,2016YFA0400900,and 2018YFA0801403);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16020603,XDB39000000,and XDB32060200);the National Natural Science Foundation of China(81925009,81790644,61890953,31322024,81371066,91432104,81900855,31900712,and 31800901);Guangdong Provincial Key Research and Development Program(2019B030335001 and 2018B030338001);Anhui Provincial Natural Science Foundation(1808085MH289 and 1908085MC66);the Fundamental Research Funds for the Central Universities(WK2070000174 and WK2090050048)。
Retinitis pigmentosa(RP)is a form of inherited retinal degenerative diseases that ultimately involves the macula,which is present in primates but not in the rodents.Therefore,creating nonhuman primate(NHP)models of RP...
关键词:Nonhuman primate model Retinitis pigmentosa RHODOPSIN Disease model Gene editing SaCas9 
Heterologous expression and cell membrane localization of dinoflagellate opsins (rhodopsin proteins) in mammalian cells
《Marine Life Science & Technology》2020年第3期302-308,共7页Minglei Ma Xinguo Shi Senjie Lin 
The work was supported by the National Key Research and Development Program Grant(No.2017YFC1404302);Natural Science Foundation of China Grants NSFC(Nos.31661143029 and 41776116).
Rhodopsins are now found in all domains of life,and are classified into two large groups:type II,found in animals and type I found in microbes including Bacteria,Archaea,and Eukarya.While type II rhodopsin functions i...
关键词:Dinoflagellate rhodopsins Proteorhodopsin-Subcellular localization HEK 293T cells 
Simulation of contribution of rhodopsin for forming afterimage
《Optoelectronics Letters》2019年第3期236-240,共5页HE Zhen-ni SHANG Chen-jing ZHANG Chun-ping 
supported by the National Natural Science Foundation of China(No.41706137);the Natural Science Foundation of Guangdong Province in China(No.2017A030310332)
The regeneration rates of rhodopsin under weak and bright light are stimulated, and a model of three energy levels is founded to simulate the photocycle and regeneration rhodopsin when rhodopsin is illuminated by weak...
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