Visual function restoration with a highly sensitive and fast Channelrhodopsin in blind mice  

作　　者：Fei Chen Xiaodong Duan Yao Yu Shang Yang Yuanyuan Chen Christine EGee Georg Nagel Kang Zhang Shiqiang Gao Yin Shen 

机构地区：[1]Eye Center,Wuhan University Renmin Hospital,Wuhan,China [2]Department of Neurophysiology,Institute of Physiology,Biocenter,University of Wuerzburg,Wuerzburg,Germany [3]Institute for Synaptic Physiology,University Medical Center Hamburg Eppendorf,Hamburg,Germany [4]Center for Biomedicine and Innovations,Faculty of Medicine,Macao University of Science and Technology and University Hospital,Macao,China [5]Frontier Science Center for Immunology and Metabolism,and Medical Research Institute at School of Medicine,Wuhan University,Wuhan,China

出　　处：《Signal Transduction and Targeted Therapy》2022年第5期1389-1391,共3页信号转导与靶向治疗（英文）

基　　金：This work was supported by National Key R&D Program of China(2017YFE0103400)to Y.S.;National Nature Science Foundation of China(81900874)to Y.C.,Macao Science and Technology Development Fund to Kang Zhang(0007/2020/AFJ);the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)Projektnummer 374031971 TRR 240 A04 and DFG Projektnummer 417451587 to G.N.

摘　　要：Inherited and age-related retinal degenerative diseases cause progressive loss of photoreceptors,ultimately leading to blindness.Optogenetics is a promising strategy for restoring visual function through photosensitive proteins’ectopic expression in surviving retinal neurons.1 Very recently,the optogenetic method with a red-shifted Channelrhodopsin was clinically applied for partial recovery of visual function in a blind patient.2 However,major obstacles to achieving optimal optogenetic vision restoration are either the low light sensitivity or the slow kinetics of existing rhodopsin-based optogenetic tools,which can be improved by molecular engineering to enhance the efficacy of fast Channelrhodopsins(ChRs).

关 键 词：VISUAL VISUAL function 

分 类 号：R774.1[医药卫生—眼科]