CILIUM

作品数：19被引量：40H指数：3
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相关领域：生物学医药卫生更多>>
相关机构：兰州军区兰州总医院更多>>
相关期刊：《Genes & Diseases》《World Journal of Nephrology》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金湖北省自然科学基金World Health Organization国家重点基础研究发展计划更多>>
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An improved method for tubulin staining of ciliated eukaryotes
《Water Biology and Security》2024年第3期65-71,共7页Tingting Pan Jing Zhang Che Hu Guanxiong Yan Weiwei Qin Zixin Cheng Dongxia Yuan Fang Zhou Jie Xiong Wei Miao Chuanqi Jiang 
supported by the Third Xinjiang Scientific Expedition Program(2021xjkk0204,2021xjkk0604);Science&Technology Fundamental Resources Investigation Program(2022FY100400);Background Resources Survey in Shennongjia National Park(SNJNP2022008);Hubei Provincial Key Laboratory for Conservation Biology of Shennongjia Snub-nosed Monkeys(SNJGKL2022008);Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation,Beibu Gulf University(2020KA05).
Ciliated microeukaryotes(ciliates)are distinguished by their cilia,which are rich in tubulin.We developed a method for tubulin staining in ciliate cells that involves using live-cell tubulin-staining dyes instead of a...
关键词：CILIATE CILIUM Live-cell tubulin dye Tubulin staining 
Acute Bacillus cereus endophthalmitis caused by ocular perforation injury and occult intravitreal cilium implantation:a case report
《International Journal of Ophthalmology(English edition)》2024年第5期976-978,共3页Ling Zhang Bin Chen Wei-Min He 
Dear Editor,We present a case of acute Bacillus cereus(B.cereus)endophthalmitis in a patient with an intraocular perforation injury combined with occult intravitreal cilium implantation.B.cereus endophthalmitis is a s...
关键词：ENDOPHTHALMITIS ILIUM injuries 
The endoplasmic reticulum membrane protein complex subunit Emc6 is essential for rhodopsin localization and photoreceptor cell survival
《Genes & Diseases》2024年第2期1035-1049,共15页Kuanxiang Sun Lu Liu Xiaoyan Jiang Heting Wang Lin Wang Yeming Yang Wenjing Liu Lin Zhang Xiaohui Zhao Xianjun Zhu 
supported by The National Natural Science Foundation of China(No.82121003,81970841,82101160);the program of Science and Technology International Cooperation Project of Qinghai province(China)(No.2022-HZ-814);the CAMS Innovation Fund for Medical Sciences(No.2019-12M-5-032);Sichuan Intellectual Property Office(China)(No.2022-ZS-0070);the Department of Chengdu Science and Technology(Sichuan,China)(No.2021-YF05-01316-SN).
The endoplasmic reticulum(ER)membrane protein complex(EMC)is responsible for monitoring the biogenesis and synthetic quality of membrane proteins with tail-anchored or multiple transmembrane domains.The EMC subunit EM...
关键词：ANO2 CILIUM EMC6 ER membrane protein complex Mislocalization Photoreceptor degeneration TMEM67 
Pathologically relevant aldoses and environmental aldehydes cause cilium disassembly via formyl group-mediated mechanisms
《Journal of Molecular Cell Biology》2024年第1期15-28,共14页Te Li Min Liu Fan Yu Song Yang Weiwen Bu Kai Liu Jia Yang Hua Ni Mulin Yang Hanxiao Yin Renjie Hong Dengwen Li Huijie Zhao Jun Zhou 
supported by grants from the National Natural Science Foundation of China(31991193 and 32230025);the National Key R&D Program of China(2021YFA1101001).
Carbohydrate metabolism disorders(CMDs),such as diabetes,galactosemia,and mannosidosis,cause ciliopathy-like multiorgan defects.However,the mechanistic link of cilia to CMD complications is still poorly understood.Her...
关键词：carbohydrate metabolism disorder ALDOSE ALDEHYDE cilium disassembly formyl group calcium influx HDAC6 
Cilia regeneration requires an RNA splicing factor from the ciliary base被引量：1
《Cell Regeneration》2022年第1期303-314,共12页Kaiming Xu Guangshuo Ou 
This work was supported by the National Natural Science Foundation of China(grants 31991190,31730052,31525015,31861143042,31561130153,31671444,31871352);the National Key R&D Program of China(2017YFA0503501,2019YFA0508401,and 2017YFA0102900)。
Cilia are microtubule-based organelles projected from most eukaryotic cell surfaces performing cell motility and signaling.Several previously recognized non-ciliary proteins play crucial roles in cilium formation and ...
关键词：PRP-8/PRPF8 RNA splicing factor CILIOGENESIS Cilium regeneration 
The roles of intraflagellar transport (IFT) protein 25 in mammalian signaling transduction and flagellogenesis被引量：1
《Asian Journal of Andrology》2022年第3期238-242,共5页Yong-Hong Man Isabella Warmbrunn Ling Zhang Zhi-Bing Zhang 
supported by the Natural Science Foundation of Hubei Province(Excellent Youth Foundation,No.2018CFA040);the Outstanding Young and Middle-aged Technology Innovation Team Project of the Hubei Provincial Department of Education(No.T2020003);NIH grant(No.HD076257);Wayne State University Start-up fund.
Cilium,an organelle with a unique proteome and organization,protruding from the cell surface,generally serves as a force generator and signaling compartment.During ciliogenesis,ciliary proteins are synthesized in cyto...
关键词：IFT25 CILIUM hedgehog signaling intraflagellar transport SPERMATOGENESIS 
Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly被引量：1
《Cell Research》2022年第2期190-209,共20页Lei Wang Sharad C.Paudyal Yuchen Kang Mikito Owa Feng-Xia Liang Alexander Spektor Holger Knaut Irma Sánchez Brian D.Dynlacht 
We are especially grateful to C.Janke for the gift of antibodies and plasmids and advice about polyglutamylation experiments and reagents.We thank NYULH DART Microscopy Laboratory Chris Petzold,Yan Deng and Kristen Dancel-Manning for assistance with CLEM work,and this core is partially funded by NYU Cancer Center Support Grant NIH/NCI P30CA016087;We thank B.Ueberheide and the NYU Langone’s Proteomics Laboratory for assistance with MS analysis.The Proteomics Laboratory is supported in part by NYU Langone Health and the Laura and Isaac Perlmutter Cancer Center support grant P30CA016087 from the National Cancer Institute.The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Research Resources or the National Institutes of Health.We thank D.-S.Lim,J.Kim,Y.Lin,J.I.Cheeseman,K.Ikegami,S.Mitsutoshi and A.Lennon-Duménil for the generous gifts of plasmids and antibodies detailed in Materials and methods.Work in H.Knaut’s laboratory was supported by R01NS102322;Work in BDD’s laboratory was supported by 9R01GM120776;a DOD prostate cancer postdoctoral training award W81XWH-16-1-0392 to L.W.
Cytoskeletal networks play an important role in regulating nuclear morphology and ciliogenesis.However,the role of microtubule(MT)post-translational modifications in nuclear shape regulation and cilium disassembly has...
关键词：thereby finding shape 
Primary cilia in hard tissue development and diseases被引量：4
《Frontiers of Medicine》2021年第5期657-678,共22页Sijin Li Han Zhang Yao Sun 
This work was supported by grants from the National Natural Science Foundation of China(Nos.82061130222,81822012,81771043,92049201,81770873,and 81802193);the National Science and Technology Major Project of China(No.2016YFC1102705);the Shanghai Academic Leader of Science and Technology Innovation Action Plan(No.20XD1424000);the Shanghai Experimental Animal Research Project of Science and Technology Innovation Action Plan(No.8191101676).
Bone and teeth are hard tissues.Hard tissue diseases have a serious effect on human survival and quality of life.Primary cilia are protrusions on the surfaces of cells.As antennas,they are distributed on the membrane ...
关键词：primary cilia BONE mechanical sensing hard tissue cilium-related bone disease TOOTH 
A non-mitotic role for Eg5 in regulating cilium formation and sonic hedgehog signaling被引量：1
《Science Bulletin》2021年第16期1620-1623,M0003,共5页Jie Ran Haixia Li Yao Zhang Fan Yu Yunfan Yang Chao Nie Song Yang Dengwen Li Jun Zhou Min Liu 
This work was supported by the National Key R&D Program of China(2018YFA0107001);the National Natural Science Foundation of China(31671403 and 31701169).
Cilia are hair-like organelles that protrude from the surface of many types of eukaryotic cells.Each cilium possesses a microtubule-based central core,known as the axoneme,surrounded by the ciliary membrane.Ciliogenes...
关键词：家族其他成员 小头畸形 驱动蛋白 Eg5 有丝分裂 人类疾病 ATP酶活性 环境感知 
A cilium-independent role for intraflagellar transport 88 in regulating angiogenesis被引量：3
《Science Bulletin》2021年第7期727-739,M0004,共14页Yang Yang Miao Chen Jingrui Li Renjie Hong Jia Yang Fan Yu Te Li Song Yang Jie Ran Chunyue Guo Yi Zhao Yi Luan Min Liu Dengwen Li Songbo Xie Jun Zhou 
supported by grants from the National Key R&D Program of China(2017YFA0503502);the National Natural Science Foundation of China(31730050,31871347,and 31900502)。
Endothelial cilia are microtubule-based hair-like protrusions in the lumen of blood vessels that function as fluid mechanosensors to regulate vascular hemodynamics. However, the functions of endothelial cilia in vascu...
关键词：IFT88 ANGIOGENESIS CILIUM Cell migration Cell division Microtubule stability 
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