The roles of intraflagellar transport (IFT) protein 25 in mammalian signaling transduction and flagellogenesis  

作　　者：Yong-Hong Man Isabella Warmbrunn Ling Zhang Zhi-Bing Zhang 

机构地区：[1]Department of Occupational and Environmental Medicine,School of Public Health,Wuhan University of Science and Technology,Wuhan 430065,China [2]Center of Scientific Research and Experiment,Nanyang Medical College,Nanyang 473006,China [3]Department of Physiology,Wayne State University School of Medicine,Detroit,MI 48201,USA [4]Department of Obstetrics and Gynecology,Wayne State University School of Medicine,Detroit,MI 48201,USA

出　　处：《Asian Journal of Andrology》2022年第3期238-242,共5页亚洲男性学杂志（英文版）

基　　金：supported by the Natural Science Foundation of Hubei Province(Excellent Youth Foundation,No.2018CFA040);the Outstanding Young and Middle-aged Technology Innovation Team Project of the Hubei Provincial Department of Education(No.T2020003);NIH grant(No.HD076257);Wayne State University Start-up fund.

摘　　要：Cilium,an organelle with a unique proteome and organization,protruding from the cell surface,generally serves as a force generator and signaling compartment.During ciliogenesis,ciliary proteins are synthesized in cytoplasm and transported into cilia by intraflagellar transport(IFT)particles,where the inner counterparts undergo reverse trafficking.The homeostasis of IFT plays a key role in cilial structure assembly and signaling transduction.Much progress has been made on the mechanisms and functions of IFT;however,recent studies have revealed the involvement of IFT particle subunits in organogenesis and spermatogenesis.In this review,we discuss new concepts concerning the molecular functions of IFT protein IFT25 and how its interactions with other IFT particle subunits are involved in mammalian development and fertility.

关 键 词：IFT25 CILIUM hedgehog signaling intraflagellar transport SPERMATOGENESIS 

分 类 号：R697[医药卫生—泌尿科学]