SPERMATOGENESIS

作品数：359被引量：1218H指数：16
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A convenient research strategy for functional verification of epigenetic regulators during spermatogenesis
《Asian Journal of Andrology》2025年第2期261-267,共7页Shan Li Ying Yuan Ke-Yu Zhang Yi-Dan Guo Lu-Tong Wang Xiao-Yuan Zhang Shu Zhang Qi Yan Rong Zhang Jie Chen Feng-Tang Yang Jing-Rui Li 
financially supported by the Shandong Provincial Natural Science Foundation(No.ZR2021QC182).
Spermatogenesis is a fundamental process that requires a tightly controlled epigenetic event in spermatogonial stem cells(SSCs).The mechanisms underlying the transition from SSCs to sperm are largely unknown.Most stud...
关键词：JMJD1A JMJD2C H3K9me2 SPERMATOGENESIS spermatogonial stem cell 
The circadian clock orchestrates spermatogonial differentiation and fertilization by regulating retinoic acid signaling in vertebrates
《National Science Review》2025年第3期134-152,共19页Taole Liu Wei He Zhaomin Zhong Chenchen Lu Lianxin Wu Ziming Wang William Kojo Smith Quan Shi Qiaoming Long Han Wang 
supported by the National Key R&D Program of China(2019YFA0802400 and 2018YFA0801000);the National Basic Research Program of China(2012CB947600);the National Natural Science Foundation of China(31961133026,31871187,31030062,81570171 and 81070455);the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions.
The circadian clock generates and maintains~24-hour oscillations in almost all organs.The testis,however,remains mysterious,without a clear understanding of its circadian functions.Our time-series transcriptome analys...
关键词：TESTIS circadian clock SPERMATOGENESIS FERTILIZATION retinoic acid ZEBRAFISH mice 
Single-cell analyses reveal impaired type B spermatogonia differentiation and meiotic entry in C-Nap1-null testes
《Quantitative Biology》2025年第1期63-75,共13页Junlin Li Liheng Yang Liansheng Li Min Li Juntao Gao Li Yuan 
The Fundamental Research Funds for the Central Universities,Grant/Award Number:E1E43201X2;The Beijing Municipal Natural Science Foundation,Grant/Award Number:Z200021;The CAS Interdisciplinary Innovation Team,Grant/Award Number:JCTD-2020-04;The National Key Research and Development Program of China,Grant/Award Numbers:2021YFE0201100,2022YFA1103401;The National Natural Science Foundation of China,Grant/Award Number:31872839。
Sperm development is critical for male reproductive capability;any disruption during the process of spermatogenesis will result in male infertility.In this research,we used the C-Nap1 encoded by the gene of Cep250 kno...
关键词：C-Nap1 mouse testis single-cell RNA sequencing SPERMATOGENESIS 
G6PC3 is involved in spermatogenesis by maintaining meiotic sex chromosome inactivation
《Acta Biochimica et Biophysica Sinica》2025年第2期286-294,共9页Yuming Cao Shengnan Wang Liyang Li Wenwen Li Yan Liang Fei Ao Zexiao Wei Li Wang 
supported by the grants from the National Natural Science Foundation of China(No.82301804);the China Postdoctoral Science Foundation(No.2023M734014).
Meiosis,a process unique to germ cells,involves formation and repair of double-stranded nicks in DNA,pairing and segregation of homologous chromosomes,which ultimately achieves recombination of homologous chromosomes....
关键词：glucose 6 phosphatase catalytic 3(G6PC3) SPERMATOGENESIS sex chromosomes pachytene arrest meiotic sex chromosome inactivation 
Dual roles ofα1,4-galactosyltransferase 1 in spermatogenesis of Drosophila melanogaster
《Insect Science》2025年第1期127-139,共13页Yanhong Xiao Bo Huang Sibo Chen Zhikai Lin Zhiying Zhu Yuzhen Lu Xiao-Qiang Yu Liang Wen Qihao Hu 
supported by the National Natural Science Foundation of China(32300389);Guangdong Basic and Applied Basic Research(2022A1515111055).
Spermatogenesis is critical for insect reproduction and the process is regulated by multiple genes.Glycosyltransferases have been shown to participate in the development of Drosophila melanogaster;however,their role i...
关键词：APOPTOSIS α4GT1 GALACTOSYLTRANSFERASE INDIVIDUALIZATION SPERMATOGENESIS 
A behind-the-scenes role of BDNF in the survival and differentiation of spermatogonia
《Asian Journal of Andrology》2025年第1期37-43,共7页Shin-ichi Tomizawa Kazushige Kuroha Michio Ono Kuniko Nakajima Kazuyuki Ohbo 
partly supported by Grant-in-Aid for Scientific Research on Innovative Areas funding from the Ministry of Education,Culture,Sports,Science,and Technology(MEXT)KAKENHI(No.22H04677 to KO);a grant from the Japan Society for the Promotion of Science KAKENHI(No.20K09543 to ST,No.20K07228 to KK,and No.19KK0183 to KO);the Takeda Science Foundation(2021 to KK).
Mouse spermatogenesis entails the maintenance and self-renewal of spermatogonial stem cells(SSCs),which require a complex web-like signaling network transduced by various cytokines.Although brain-derived neurotrophic ...
关键词：BDNF SPERMATOGENESIS SPERMATOGONIA stem cells 
Both 20S and 19S proteasome components are essential for meiosis in male mice
《Zoological Research》2025年第1期27-40,共14页Ting-Ting Han Li-Ying Wang Qiu-Xing Zhou Wei Wei Yan-Jie Ma Ying-Hong Chen Wei Li Zhen-Yu Ju Chao Liu 
supported by the National Science Fund for Distinguished Young Scholars (81925015);Science and Technology Project of Guangzhou (2023A03J0886,2023A03J0871);National Natural Science Foundation of China (82030039,32400709)。
The proteasome,an evolutionarily conserved proteolytic complex comprising the 20S core particle and 19S regulatory particles,performs both shared and distinct functions across various tissues and organs.Spermatogenesi...
关键词：PROTEASOME PSMA1 PSMD2 Meiotic initiation SPERMATOGENESIS 
Core factor of NEXT complex,ZCCHC8,governs the silencing of LINE1 during spermatogenesis
《National Science Review》2025年第1期37-47,共11页Rushuang Yan Meijie Qi Pengfei Zhang Bin Shen Jiqing Yin Chuan Chen Silin Tian Lin Chen Xingxu Huang Hong Wang Shaorong Gao You Wu Yawei Gao 
supported by the National Key R&D Program of China(2020YFA0113200[Y.G.],2021YFC2700300[S.G.]and 2022YFC2702200[S.G.]);the National Natural Science Foundation of China(32370869[Y.G.],32330030[S.G.],92168205[S.G.],32200694[Y.W],82301859[M.Q.]);Peak Disciplines(Type IV)of Institutions of Higher Learning in Shanghai(S.G.),Young Elite Scientists Sponsorship Program by CAST(2023QNRC001[Y.W]);the key project of the Science and Technology of Shanghai Municipality(21JC1405500[S.G.]);the Shanghai Rising-Star Program(22YF1436200[Y.W.]);the Shanghai Pilot Program for Basic Research(Y.G.),Special Fund for Health Science and Technology of Social Development Shanghai Pudong New Area(PKJ2022-Y20)(L.C.);Fundamental Research Funds for the Central Universities and the China Postdoctoral Science Foundation(2023M733267[P.Z.]).
The overactivation of transposable elements(TEs)is a significant threat to male reproduction,particularly during the delicate process of spermatogenesis.Here,we report that zinc finger protein ZCCHC8-a key component o...
关键词：transposon elements nuclear exosome targeting complex LINE1 spermatogonial stem cells SPERMATOGENESIS 
Photoperiod-regulated mitophagy in the germ cells of Brandt’s voles (Lasiopodomys brandtii)
《Integrative Zoology》2024年第6期1105-1120,共16页Lijuan ZHAO Chunxiao CHEN Lewen WANG Yan LIU Fanglei GONG Jingou WANG Hong SUN Dawei WANG Zhenlong WANG 
supported by the fellowship of China Postdoctoral Science Foundation(2022M712901);the National Natural Science Foundation of China(Grant 32301302 to Lijuan Zhao and Grants 31972284,31471790,and 32372571 to Dawei Wang);the Zhongyuan Science and Technology Innovation Leading Talent Project(Grant 224200510001 to Zhenlong Wang);the fellowship of China Postdoctoral Science Foundation(2022M712898).
Photoperiod is a pivotal factor in affecting testicular function and spermatogenesis in seasonal-breeding animals.Mitophagy is essential for spermatogenesis,but its association with seasonal photoperiods has not been ...
关键词：Brandt’s vole MITOPHAGY PHOTOPERIOD SPERMATOGENESIS 
The emerging and diverse roles of F-box proteins in spermatogenesis and male infertility
《Cell Regeneration》2024年第1期253-264,共12页Xuan Zhuang Jun Ruan Canquan Zhou Zhiming Li 
National Natural Science Foundation of China(82371627);Open Research Fund of Key Laboratory of Reproductive Medicine of Guangdong Province(2020B121206002902);Natural Science Foundation of Fujian Province(2021J011346);Xiamen Medical and Health Guidance Project(3502Z20244ZD1021).
F-box proteins play essential roles in various cellular processes of spermatogenesis by means of ubiquitylation and subsequent target protein degradation.They are the substrate-recognition subunits of SKP1–cullin 1–...
关键词：F-box proteins UBIQUITYLATION SPERMATOGENESIS Male infertility Male germ cells 
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