UBIQUITYLATION

作品数：29被引量：93H指数：6
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相关领域：生物学更多>>
相关作者：李亭亭张令强郑晓峰更多>>
相关机构：景德镇陶瓷大学北京大学军事医学科学院更多>>
相关期刊：《Frontiers in Biology》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《Journal of Clinical and Translational Hepatology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry更多>>
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NUMB endocytic adaptor protein(NUMB)mediates the anti-hepatic fibrosis effect of artesunate(ART)by inducing senescence in hepatic stellate cells(HSCs)
《Chinese Journal of Natural Medicines》2025年第3期322-333,共12页Yangling Qiu Yujia Li Mengran Li Yingqian Wang Min Shen Jiangjuan Shao Feng Zhang Xuefen Xu Feixia Wang Zili Zhang Shizhong Zheng 
supported by the National Natural Science Foundation of China(Nos.82474164,82374124,82073914,82173874,82274185,82305046 and 82304902);the Natural Science Foundation of Jiangsu Province(Nos.BK20230458 and BK20220467);the General Project of the Natural Science Research of Jiangsu Higher Education Institutions(No.23KJB310017);Young Elite Scientists Sponsorship Program by CACM(No.2022-QNRC2-B15).
Developing and identifying effective medications and targets for treating hepatic fibrosis is an urgent priority.Our previous research demonstrated the efficacy of artesunate(ART)in alleviating liver fibrosis by elimi...
关键词：Hepatic stellate cells NUMB endocytic adaptor protein SENESCENCE ARTESUNATE UBIQUITYLATION Liver fibrosis 
Epigenetics disruptions enabled by porphyrin-derived metal-organic frameworks disarm resistances to sonocatalytic ROS anti-tumor actions
《Fundamental Research》2025年第1期296-306,共11页Yan Zhang Dou Du Chao Fang Xin Yu Yujia Fang Xinyu Liu Di Ou Haohao Yin Hui Liu Taixia Wang Lu Lu Xiaolong Li Kun Zhang 
supported by the Excellent Young Scientists Fund of National Natural Science Foundation of China(82022033);National Natural Science Foundation of China(81901753 and 82001820);Shanghai Rising-Star Program(19QA1406800);Shanghai Talent Development Fund(2019040);the Fundamental Research Funds for the Central Universities(22120210561);the program for Shanghai Young Top-Notch Talent.
Post-transcriptional epigenetic modifications provide numerous implications for tumor progression,metastasis and recurrence,which also pose resistances to reactive oxygen species(ROS)-based anti-tumor.Herein,we propos...
关键词：Epigenetics engineering Ubiquitylation modulation SONOCATALYSIS Reactive oxygen species resistance Anti-tumor action 
The emerging and diverse roles of F-box proteins in spermatogenesis and male infertility
《Cell Regeneration》2024年第1期253-264,共12页Xuan Zhuang Jun Ruan Canquan Zhou Zhiming Li 
National Natural Science Foundation of China(82371627);Open Research Fund of Key Laboratory of Reproductive Medicine of Guangdong Province(2020B121206002902);Natural Science Foundation of Fujian Province(2021J011346);Xiamen Medical and Health Guidance Project(3502Z20244ZD1021).
F-box proteins play essential roles in various cellular processes of spermatogenesis by means of ubiquitylation and subsequent target protein degradation.They are the substrate-recognition subunits of SKP1–cullin 1–...
关键词：F-box proteins UBIQUITYLATION SPERMATOGENESIS Male infertility Male germ cells 
IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2
《Bone Research》2024年第4期933-951,共19页Zengfa Deng Dianbo Long Changzhao Li Hailong Liu Wei Li Yanlin Zhong Xiaolin Mo Ruiyun Li Zibo Yang Yan Kang Guping Mao 
supported by the National Natural Science Foundation of China (82202739);Guangdong Basic and Applied Basic Research Foundation Natural Science Fund Project-Youth Promotion Project (2024A1515030260);China Statefunded Postdoctoral Researchers Program (GZC20233265);National Natural Science Foundation of China (81972051)。
Osteoarthritis(OA)is an age-related cartilage-degenerating joint disease.Mitochondrial dysfunction has been reported to promote the development of OA.Poly(ADP-ribose)polymerase family member 12(PARP12)is a key regulat...
关键词：PARP1 INHIBITING cartilage 
Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ
《Frontiers of Medicine》2024年第3期465-483,共19页Fei Xu Han Chen Changyi Zhou Tongtong Zang Rui Wang Shutong Shen Chaofu Li Yue Yu Zhiqiang Pei Li Shen Juying Qian Junbo Ge 
supported by grants from the National Key R&D Program of China(No.2021YFC2500500);the National Natural Science Foundation of China(Nos.T2288101 and 82170342);Shanghai Engineering Research Center of Interventional Medicine(No.19DZ2250300);Shanghai Clinical Research Center for Interventional Medicine(No.19MC1910300).
Atherosclerosis is a chronic artery disease that causes various types of cardiovascular dysfunction.Vascular smooth muscle cells(VSMCs),the main components of atherosclerotic plaque,switch from contractile to syntheti...
关键词：ATHEROSCLEROSIS vascular smooth muscle cell UBIQUITYLATION deubiquitinase OTUB1 PDGFRβ 
Corrigendum: RP11-40C6.2 Inactivates Hippo Signaling by Attenuating YAP1 Ubiquitylation in Hepatitis B Virusassociated Hepatocellular Carcinoma
《Journal of Clinical and Translational Hepatology》2023年第5期1286-1290,共5页
Citation of this article:Huang RR,Giafaglione JM,Hashimoto T,Zhang L,Yu W,Rao J,et al.Corrigendum:RP11-40C6.2 Inactivates Hippo Signaling by Attenuating YAP1 Ubiquitylation in Hepatitis B Virus-associated Hepatocellul...
关键词：YAP1 CARCINOMA COR 
RP11-40C6.2 Inactivates Hippo Signaling by Attenuating YAP1 Ubiquitylation in Hepatitis B Virus-associated Hepatocellular Carcinoma被引量：4
《Journal of Clinical and Translational Hepatology》2023年第2期323-333,共11页Han Zhuo Chen Wu Junwei Tang Feihong Zhang Zhenggang Xu Dongwei Sun Yue Teng Zhongming Tan 
supported by grants from the National Natural Science Foundation (Grant Number 81972675 to T.Z.M.)。
Background and Aims:Chronic hepatitis caused by hepatitis B virus(HBV)infection is a leading cause of hepatocellular carcinoma(HCC).We investigated the roles of oncogenic HBV infection-associated long noncoding RNAs i...
关键词：Hepatocellular carcinoma Hippo signaling lncRNA YAP1 HBV 
Chemical tools for E3 ubiquitin ligase study
《Chinese Chemical Letters》2023年第4期67-74,共8页Yangwode Jing Chong Zuo Yun-Xiang Du Junxiong Mao Ruichao Ding Jiachen Zhang Lu-Jun Liang Qian Qu 
E3 ubiquitin ligases catalyze the final step of ubiquitylation,a crucial post-translational modification involved in almost every process in eukaryotic cells.E3 ubiquitin ligases are key regulators of cellular events,...
关键词：Chemical tools Protein chemical synthesis UBIQUITYLATION E3 ligase Enzymatic mechanism 
Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke被引量：4
《Journal of Pharmaceutical Analysis》2023年第2期156-169,共14页Zexuan Hong Jun Cao Dandan Liu Maozhu Liu Mengyuan Chen Fanning Zeng Zaisheng Qin Jigang Wang Tao Tao 
the National Natural Science Foundation of China(Grant No.:81973305);the Science and Technology Planning Project of Guangzhou,China(Grant No.:201904010487);the Natural Science Foundation of Guangdong Province,China(Grant No.:2021A1515010897);the Discipline Construction Fund of Central People’s Hospital of Zhanjiang(Grant Nos.:2020A01 and 2020A02).
Stroke is the second leading cause of death worldwide,and oxidative stress plays a crucial role.Celastrol exhibits strong antioxidant properties in several diseases;however,whether it can affect oxidation in cerebral ...
关键词：CELASTROL Cerebral ischemia Reperfusion injury Oxidative stress Nedd4 Nrf2 UBIQUITYLATION 
A non-metabolic function of hexokinase 2 in small cell lung cancer:promotes cancer cell stemness by increasing USP11-mediated CD133 stability被引量：7
《Cancer Communications》2022年第10期1008-1027,共20页Juhong Wang Fei Shao Yannan Yang Wei Wang Xueying Yang Renda Li Hong Cheng Sijin Sun Xiaoli Feng Yibo Gao Jie He Zhimin Lu 
Ministry of Science and Technology of the People’s Republic of China,Grant/Award Number:2020YFA0803300;National Natural Science Foundation of China,Grant/Award Numbers:82188102,82030074,82122053,32100574;Beijing Municipal Science&Technology Commission,Grant/Award Number:Z191100006619115;R&D Program of Beijing Municipal Education commission,Grant/Award Number:KJZD20191002302;CAMS Innovation Fund for Medical Science,Grant/Award Numbers:2021-1-I2M-012,2021-I2M-1-067;Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences,Grant/Award Number:2021-PT310-001;Key-Area Research and Development Program of Guangdong Province,Grant/Award Number:2021B0101420005;Sanming Project of Medicine in Shenzhen,Grant/Award Numbers:SZSM201612097,SZSM201812062;Aiyou Foundation,Grant/Award Number:KY201701;Natural Science Foundation of Shandong Province,Grant/Award Number:ZR2020QH191;Zhejiang Natural Science Foundation-Key Project,Grant/Award Number:LD21H160003;Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang,Grant/Award Number:2019R01001;Zhimin Lu is the Kuancheng Wang Distinguished Chair。
Background:Maintenance of cancer stem-like cell(CSC)stemness supported by aberrantly regulated cancer cell metabolism is critical for CSC self-renewal and tumor progression.As a key glycolytic enzyme,hexokinase 2(HK2)...
关键词：HK2 metabolic enzyme non-metabolic function cancer stem-like cell CD133 USP11 UBIQUITYLATION SCLC 
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