CELASTROL

作品数：55被引量：194H指数：9
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相关机构：南昌大学第一附属医院中山大学南京师范大学广州医科大学更多>>
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Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression
《Acta Pharmaceutica Sinica B》2025年第2期876-891,共16页Yuyu Zhu Lixin Zhao Wei Yan Hongyue Ma Wanjun Zhao Jiao Qu Wei Zheng Chenyang Zhang Haojie Du Meng Yu Ning Wan Hui Ye Yicheng Xie Bowen Ke Qiang Xu Haiyan Sun Yang Sun Zijun Ouyang 
supported by the National Key Research and Development Plan(2022YFC3500202,China);the National Natural Science Foundation of China(Nos.82230116,81872877,82204715,81803142,82404639,and 82073975);the Natural Science Foundation of Jiangsu Province(No.BK20220476,China);the Jiangsu Provincial Double-Innovation Doctor Program(No.JSSCBS20220477,China);the Natural Science Foundation of Nanjing University of Chinese Medicine(No.XPT82204715,China);the Fundamental Research Funds for the Central Universities(Nos.020814380179 and 020814380174,China);the Fundamental Science(Natural Science)Research Project of the Jiangsu Higher Education Institutions of China(No.22KJB360005);the Innovation Project of Guangdong Provincial Education Department(No.2023KTSCX320,China);the Shenzhen Science and Technology Program(Nos.20231126130044001 and 20230731094501002,China);the School of Life Science(NJU)-Sipimo Joint Funds,and the Mountain-Climbing Talents Project of Nanjing.
Psoriasis is an incurable chronic inflammatory disease that requires new interventions.Here,we found that fibroblasts exacerbate psoriasis progression by promoting macrophage recruitment via CCL2 secretion by single-c...
关键词：PSORIASIS FIBROBLAST CCL2 CELASTROL LRP1 MACROPHAGE C-JUN Drug target 
A biomimetic,triggered-release micelle formulation of methotrexate and celastrol controls collagen-induced arthritis in mice
《BMEMat(BioMedical Engineering Materials)》2024年第4期130-141,共12页He Ren Zewen Wu Jingxuan Li Nan Zhang Coo Yee Nah Jiexin Li Jingyu Zhang Jonathan F.Lovell Liyun Zhang Yumiao Zhang 
This work was supported by the National Natural Science Foundation of China(22375144 and 32071384);the National Key Research and Development Program(2021YFC2102300);the basic research project of Shanxi Science and Technology Department(202103021224342);Key Research and Development(R&D)Projects of Shanxi Province(2021XM01).
Rheumatoid arthritis(RA)is a systemic autoimmune disease that leads to the destruction of articular cartilage and bone.RA is characterized by immune cell infiltration and abnormal proliferation of synoviocytes in the ...
关键词：co-loading MICELLE microenvironment-responsive rheumatoid arthritis self-immolative 
Inhibitory effect of active ingredients of Tripterygium wilfordii Hook.F.on human carboxylesterases
《中国药理学与毒理学杂志》2024年第9期652-660,共9页LIANG Jiahong GONG Jiamin DU Zuo 
川北医学院博士科研启动基金(CBY20-QD02);南充市市校科技战略合作专项资金项目(20SXQT0318)。
OBJECTIVE The inhibitory effect of active ingredients of Tripterygium wilfordii Hook.F.(TWHF)(celastrol,triptolide,triptonide,wilforlide A,wilforgine and wilforine)on human carboxylester⁃ase 1(CES1)and CES2 was detect...
关键词：Tripterygium wilfordii Hook.F. CELASTROL CARBOXYLESTERASES enzyme inhibition 
Celastrol activates caspase-3/GSDME-dependent pyroptosis in tumor cells by inducing endoplasmic reticulum stress Author links open overlay panel
《Journal of Traditional Chinese Medical Sciences》2024年第3期330-339,共10页Jiajian Guo Dongxiao Cui Yuping Tang Sanjiao Wang Cuiyan Ma Wenfu Ma 
supported by grants from startup fund program at Beijing University of Chinese Medicine(90011451310011);key research fund for drug discovery in Chinese medicine at Beijing University of Chinese Medicine(1000061223476);startup fund program at Beijing University of Chinese Medicine(90020361220006).
Objective:To investigate the pyroptosis-inducing effects of celastrol on tumor cells and to explore the potential mechanisms involved,specifically focusing on the role of the caspase-3/gasdermin E(GSDME)signaling path...
关键词：CELASTROL Tumor cells PYROPTOSIS GSDME CASPASE-3 Endoplasmic reticulum stress stress Cell death Traditional Chinese medicine 
Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for reinforcing immunogenic cell death and potentiating cancer immunotherapy
《Acta Pharmaceutica Sinica B》2024年第8期3643-3660,共18页Jie Wang Zilong Zhang Yan Zhuo Zhuan Zhang Rongrong Chen Li Liang Xiaohe Jiang Di Nie Chang Liu Zhiwen Zou Xiang Li Jiaxin Li Bingqi Wang Rui Wang Yong Gan Miaorong Yu 
the financial support from the National Science Fund of Distinguished Young Scholars(No.82025032,China);the National Natural Science Foundation of China(No.82073773,China);the Key Research Program of Chinese Academy of Sciences(No.ZDBS-ZRKJZ-TLC005,China);the"Open Competition to Select the Best Candidates"Key Technology Program for Nucleic Acid Drugs of NCTIB(No.NCTIB2022HS01006,China);Young Elite Scientists Sponsorship Program by CAST(No.2022QNRC001,China);Shanghai Action Plan for Science,Technology,and Innovation(No.23HC1401200,China);Shanghai Post-doctoral Excellence Program(No.2022693,China);Shanghai Institute of Materia Medica,Chinese Academy of Sciences(No.SIMM0220232001,China).
The prospect of employing chemoimmunotherapy targeted towards the endoplasmic reticulum(ER)presents an opportunity to amplify the synergistic effects of chemotherapy and immunotherapy.In this study,we initially valida...
关键词：CHEMOIMMUNOTHERAPY Targeted drug delivery Endoplasmic reticulum Endoplasmic reticulum stress Immunogenic cell death SIRNA CHEMOIMMUNOTHERAPY Targeted drug delivery Endoplasmic reticulum Endoplasmic reticulum stress Immunogenic cell death SIRNA 
The effect of celastrol in combination with 5-fluorouracil on proliferation and apoptosis of gastric cancer cell lines
《Oncology Research》2024年第7期1231-1237,共7页MOHAMMAD-TAGHI MORADI DHIYA ALTEMEMY MAJID ASADI-SAMANI PEGAH KHOSRAVIAN MARZIYEH SOLTANI LEILA HASHEMI AZADEH SAMIEI-SEFAT 
supported by Shahrekord University of Medical Sciences,Shahrekord,Iran(Ethics Code:IR.SKUMS.REC.1397.119,Grant No.3696 and Ethics Code:IR.SKUMS.REC.1401.197,Grant No.6651).
Background:Despite the availability of chemotherapy drugs such as 5-fluorouracil(5-FU),the treatment of some cancers such as gastric cancer remains challenging due to drug resistance and side effects.This study aimed t...
关键词：Gastric cancer CELASTROL TERPENOID Cell cycle regulation APOPTOSIS Synergism 
The Mechanism of Celastrol in the Treatment of Metastatic Lung Adenocarcinoma Revealed by Network Pharmacology and Molecular Docking
《Journal of Biosciences and Medicines》2024年第6期275-285,共11页Caihua Zhang Wei Du 
Background: Celastrol is an active ingredient extracted from Traditional Chinese Medicine (TCM), which can restrain the progression of lung cancer, whereas its underlying mechanism is unclear. In our study, the underl...
关键词：CELASTROL Lung Adenocarcinoma METASTASIS Network Pharmacology Molecular Docking 
Ferroptosis inhibitors reduce celastrol toxicity and preserve its insulin sensitizing effects in insulin resistant HepG2 cells
《Journal of Integrative Medicine》2024年第3期286-294,共9页Jia-jia Liu Xue Zhang Bang-lan Cai Man-man Qi Yong-bin Chi Bin Peng Deng-hai Zhang 
Objective:Research has shown that celastrol can effectively treat a variety of diseases,yet when passing a certain dosage threshold,celastrol becomes toxic,causing complications such as liver and kidney damage and ery...
关键词：CELASTROL Insulin resistance Ferroptosis N-ACETYLCYSTEINE Palmitic acid Molecular docking 
Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis被引量：1
《Bioactive Materials》2024年第6期83-95,共13页Peng Hua Ruifeng Liang Suleixin Yang Yanbei Tu Meiwan Chen 
supported by the Science and Technology Development Fund,Macao SAR(File no.0124/2019/A3);the University of Macao(File no.MYRG2022-00203-ICMS,MYRG-GRG2023-00134-ICMS-UMDF).
Abnormal proliferation of aggressive fibroblast-like synoviocytes(FLS)and perpetuate synovial inflammation can inevitably accelerate the progression of rheumatoid arthritis(RA).Herein,a strategy of simultaneously prom...
关键词：Rheumatoid arthritis PUMA CELASTROL ANTI-INFLAMMATION Fibroblast-like synoviocyte apoptosis 
Celastrol inhibits inflammatory factors expression in glioblastoma
《Traditional Medicine Research》2024年第6期1-11,共11页Na Qin Shu-Xian Yang Shi-Man Gao Ting Zhu 
supported by the National Natural Science Foundation of China(No.82204663);the Natural Science Foundation of Shandong Province(No.ZR2022QH058).
Background:Glioblastoma is one of the most common primary intracranial tumors of the central nervous system in adults.Although chemotherapy is an important component of glioblastoma treatment,its effectiveness remains...
关键词：GLIOBLASTOMA monocytes/macrophages single-cell RNA sequencing MIF/CD74 signaling pathway CELASTROL 
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