CHEMOIMMUNOTHERAPY

作品数：30被引量：85H指数：5
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Safety and effectiveness of induction chemoimmunotherapy followed by definitive radiotherapy or concurrent chemoradiotherapy in esophageal squamous cell carcinoma
《World Journal of Clinical Oncology》2025年第3期30-39,共10页Zhuo-Jun Wei Lin Wang Rui-Qi Wang Yu Wang Huan Chen Hong-Lian Ma Yu-Jin Xu 
Supported by Natural Science Foundation of Zhejiang Province,China,No.LGF21H160005;Zhejiang Medical and Health Science and Technology Project,China,No.2024KY049.
BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a common malignancy in China,often diagnosed at an advanced stage,with poor prognosis.Standard treatments such as definitive chemoradiotherapy offer limited surviv...
关键词：Esophageal squamous cell carcinoma RADIOTHERAPY Immune checkpoint inhibitors CHEMOTHERAPY Patient safety Treatment outcome 
Intratumoral lactic acid neutralization strategy for boosting chemoimmunotherapy using liposomal sodium bicarbonate
《Science Bulletin》2024年第24期3936-3948,共13页Taoxing Peng Xinyue Shao Wenqin Song Weihua Xu Wei Xiong Yihao He Yang Ding Yongzhuo Huang 
the National Key Research and Development Program of China(2021YFC400600,2022YFE0203600);the National Natural Science Foundation of China(81925035 and 82341232);the Future Network(083GJHZ2023012FN);Grand Challenges(083GJHZ2023021GC)of the International Partnership Program of the Chinese Academyof Sciences,CAS President’s International Fellowship Initiative(2024VBB0004);High-level Innovative Research Institute(2021B0909050003)from Department of Science;Technology of Guangdong Province;Zhongshan Municipal Bureau of Science and Technology(LJ2021001 and CXTD2022011).
Glycolysis-related lactic acid overproduction creates an“ion-trapping”barrier and immunosuppressive tumor microenvironment that compromise effective intratumoral drug delivery and therapy.Therefore,normalization of ...
关键词：Sodium bicarbonate Lactic acid neutralization Tumor microenvironment normalization CHEMOIMMUNOTHERAPY PD-1 antibody Ion-trapping barrier 
Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for reinforcing immunogenic cell death and potentiating cancer immunotherapy
《Acta Pharmaceutica Sinica B》2024年第8期3643-3660,共18页Jie Wang Zilong Zhang Yan Zhuo Zhuan Zhang Rongrong Chen Li Liang Xiaohe Jiang Di Nie Chang Liu Zhiwen Zou Xiang Li Jiaxin Li Bingqi Wang Rui Wang Yong Gan Miaorong Yu 
the financial support from the National Science Fund of Distinguished Young Scholars(No.82025032,China);the National Natural Science Foundation of China(No.82073773,China);the Key Research Program of Chinese Academy of Sciences(No.ZDBS-ZRKJZ-TLC005,China);the"Open Competition to Select the Best Candidates"Key Technology Program for Nucleic Acid Drugs of NCTIB(No.NCTIB2022HS01006,China);Young Elite Scientists Sponsorship Program by CAST(No.2022QNRC001,China);Shanghai Action Plan for Science,Technology,and Innovation(No.23HC1401200,China);Shanghai Post-doctoral Excellence Program(No.2022693,China);Shanghai Institute of Materia Medica,Chinese Academy of Sciences(No.SIMM0220232001,China).
The prospect of employing chemoimmunotherapy targeted towards the endoplasmic reticulum(ER)presents an opportunity to amplify the synergistic effects of chemotherapy and immunotherapy.In this study,we initially valida...
关键词：CHEMOIMMUNOTHERAPY Targeted drug delivery Endoplasmic reticulum Endoplasmic reticulum stress Immunogenic cell death SIRNA CHEMOIMMUNOTHERAPY Targeted drug delivery Endoplasmic reticulum Endoplasmic reticulum stress Immunogenic cell death SIRNA 
Dendritic nanomedicine enhances chemoimmunotherapy by disturbing metabolism of cancer-associated fibroblasts for deep penetration and activating function of immune cells
《Acta Pharmaceutica Sinica B》2024年第8期3680-3696,共17页Yunkun Li Xiaoding Shen Haitao Ding Yuxin Zhang Dayi Pan Liping Su Yahui Wu Zaixiang Fang Jie Zhoua Qiyong Gong Kui Luo 
supported by the National Science and Technology Major Project of China(2023YFB3810004);the National Natural Science Foundation of China(32271445,52103175,32271382,32101145);the National Key Research and Development Program of China(2022YFC2009900);Department of Science and Technology of Sichuan Province(24NSFJQ0167,China);1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC21013,China);Post-Doctor Research Project,West China Hospital,Sichuan University(2021HXBH055,2021HXBH057,China);China Postdoctoral Science Foundation(2021M692314).
Inefficient drug penetration hurdled by the stroma in the tumor tissue leads to a diminished therapeutic effect for drugs and a reduced infiltration level of immune cells.Herein,we constructed a PEGylated dendritic ep...
关键词：Dendritic prodrug Enhanced penetration Metabolic intervention Cancer-associated fibroblasts Immunogenic cell death Chemotherapy Immunotherapy Immune microenvironment reconstitution 
Machine learning based on metabolomics unveils neutrophil extracellular trap-related metabolic signatures in non-small cell lung cancer patients undergoing chemoimmunotherapy
《World Journal of Clinical Cases》2024年第20期4091-4107,共17页Yu-Ning Li Jia-Lin Su Shu-Hua Tan Xing-Long Chen Tian-Li Cheng Zhou Jiang Yong-Zhong Luo Le-Meng Zhang 
the National Natural Science Foundation of Hunan Province,No.2023JJ60039;Natural Science Foundation of Hunan Province National Health Commission,No.B202303027655;Natural Science Foundation of Changsha Science and Technology Bureau,No.Kq2208150;Wu Jieping Foundation of China,No.320.6750.2022-22-59,320.6750.2022-17-41;Guangdong Association of Clinical Trials(GACT)/Chinese Thoracic Oncology Group(CTONG);and Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer,No.2017B030314120.
BACKGROUND Non-small cell lung cancer(NSCLC)is the primary form of lung cancer,and the combination of chemotherapy with immunotherapy offers promising treatment options for patients suffering from this disease.However...
关键词：Non-small cell lung cancer CHEMOIMMUNOTHERAPY Neutrophil extracellular traps Metabolomics Machine learning 
A pH/ROS dual-responsive system for effective chemoimmunotherapy against melanoma via remodeling tumor immune microenvironment被引量：1
《Acta Pharmaceutica Sinica B》2024年第5期2263-2280,共18页Leilei Wang Shanshan He Rong Liu Yuan Xue Yuan Quan Rongying Shi Xueying Yang Qing Lin Xun Sun Zhirong Zhang Ling Zhang 
We acknowledge the support from the National Science Fund for Excellent Young Scholars(No.82022070);the Regional Innovation and Development Joint Fund(No.U20A20411).
Chemotherapeutics can induce immunogenic cell death(ICD)in tumor cells,offering new possibilities for cancer therapy.However,the efficiency of the immune response generated is insufficient due to the inhibitory nature...
关键词：QUERCETIN Nanoparticle RESPONSIVENESS CHEMOIMMUNOTHERAPY Tumor immune microenvironment 
Leveraging genomics,transcriptomics and epigenomics to understand chemoimmunotherapy resistance in chronic lymphocytic leukemia
《Cancer Drug Resistance》2024年第1期956-966,共11页Shin Yeu Ong Lili Wang 
Patients with chronic lymphocytic leukemia(CLL)have differing clinical outcomes.Recent advances integrating multi-omic data have uncovered molecular subtypes in CLL with different prognostic implications and may allow...
关键词：Chronic lymphocytic leukemia CHEMOIMMUNOTHERAPY RESISTANCE 
Complete response of a locally advanced pulmonary hepatoid adenocarcinoma patient to perioperative XELOX-containing chemoimmunotherapy
《Genes & Diseases》2024年第1期1-3,共3页Kaiyan Chen Ying Yu Zhiyu Huang Lei Gong Yun Fan 
With morphological features resembling hepatocellular carcinoma,hepatoid adenocarcinoma of the lung(HAL)is a rare and aggressive subtype of lung cancer with a 5-year survival of only 8%.1 Most HAL patients present inc...
关键词：ADENOCARCINOMA PATIENT lung 
Activation of autophagy by in situ Zn^(2+) chelation reaction for enhanced tumor chemoimmunotherapy被引量：3
《Bioactive Materials》2023年第11期116-131,共16页Yang Yang Yefei Zhu Kairuo Wang Yunqiu Miao Yuanyuan Zhang Jie Gao Huanlong Qin Yang Zhang 
the National Natural Science Foundation of China(Grant No.81730102,32271384);Shanghai Basic Research Program(Grant No.20JC1411702);Shanghai Science and Technology Program(Grant No.20ZR1456100).
Chemotherapy can induce a robust T cell antitumor immune response by triggering immunogenic cell death(ICD),a process in which tumor cells convert from nonimmunogenic to immunogenic forms.However,the antitumor immune ...
关键词：CHEMOIMMUNOTHERAPY Immunogenic cell death(ICD) Damage-associated molecular patterns(DAMPs) Autophagy In situ chelation 
Intratumoral CD103^(+)CD8^(+)T cells predict response to neoadjuvant chemoimmunotherapy in advanced head and neck squamous cell carcinoma被引量：2
《Cancer Communications》2023年第10期1143-1163,共21页Siqi Ren Tianjun Lan Fan Wu Suling Chen Xue Jiang Chuying Huo Zitian Li Shule Xie Donghui Wu Ruixin Wang Yanyan Li Lin Qiu Guoxin Huang Shurui Li Xiaojuan Wang Meifeng Cen Tingting Cai Zhaoyu Lin Jinsong Li Bowen Li 
supported by the National Natural Science Foundation of China(82272788,82072990,81903045,and 82072988);China Postdoctoral Science Foundation(2021M703692);Department of Health of Guangdong Province Science Foundation(A2022165 and A2021142);Guangzhou Municipal Science and Technology Project(202201011479);Guangdong Science and Technology Development Fund(2019A1515011867 and 2020A1515010405).
Background Immune cell heterogenicity is known to determine the therapeutic response to cancer progression.Neoadjuvant chemoimmunotherapy(NACI)has shown clinical benefits in some patients with advanced head and neck s...
关键词：CD103 CD8 head and neck squamous cell carcinoma neoadjuvant chemoimmunotherapy predictive marker tumor-infiltrating lymphocyte 
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