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Traditional Chinese Medicine Integrated Multifunctional Responsive Core-Shell Microneedles for Dermatosis Treatment: 《Research》2025年第1期569-577,共9页Xi Luan Xiaoxuan Zhang Qichen Luan Jingjing Gan Yu Wang Yuanjin Zhao; supported by National Key Research and Development Program of China(2020YFA0908200);National Natural Science Foundation of China(T2225003);National Natural Science Foundation of China(52073060);National Natural Science Foundation of China(61927805);Nanjing Medical Science and Technique Development Foundation(ZKX21019);Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01);Natural Science Foundation of Jiangsu Province(BK20180408);Guangdong Basic and Applied Basic Research Foundation(2021B1515120054);Shenzhen Science and Technology Program(JCYJ20210324133214038).; Microneedles have demonstrated value in targeted treatment of dermatosis.Current investigation aims to enhance the functions and optimize substance delivery to improve therapeutic effects.Here,we present innovative sh...; 关键词：SCLERODERMA light ph dual responsiveness treat sclerodermaby chinese herb drugs spatiotemporal sequential release

Tumor-related fungi and crosstalk with gut fungi in the tumor microenvironment被引量：1: 《Cancer Biology & Medicine》2024年第11期977-994,共18页Yue Wang Yiwen Wang Yuhang Zhou Yun Feng Tao Sun Junnan Xu; supported by the National Natural Science Foundation of China(Grant No.82373113 to XJ);Shenyang Public Health R&D Special Project(Grant No.22-321-31-04 to ST);Liaoning Revitalization Talents Program(Grant No.XLYC1907160 to XJ);Beijing Medical Award Foundation(Grant Nos.YXJL-2020-0941-0752 to ST and CORP239-N27 to CH);Wu Jieping Medical Foundation(Grant Nos.320.6750.2020-12-21 and 320.6750.2020-6-30 to ST);the Fundamental Research Funds for the Central Universities(Grant Nos.202229 to ST and 202230 to XJ)。; Most studies on the human gut microbiome have focused on the bacterial fraction rather than fungal biomics,which as resulted in an incomplete understanding of the fungal microbiome.Recent advances in microbiota detect...; 关键词：Gut microbiota FUNGI INTRATUMORAL CANCER cancer treatment responsiveness Candida albicans

Multifunctional phase change film with high recyclability, adjustable thermal responsiveness, and intrinsic self-healing ability for thermal energy storage: 《Journal of Energy Chemistry》2024年第10期216-227,I0005,共13页Bo Yang Xuelai Zhang Jun Ji Weisan Hua Miaomiao Jiang; supported by the Project of Shanghai Science and Technology Commission (Grant No. 19DZ1203102);National Key Research and Development Project (2018YFD0401300);Shanghai Municipal Science and Technology Project (16040501600)。; Phase change materials(PCMs) present promising potential for guaranteeing safety in thermal management systems.However,most reported PCMs have a single application in energy storage for thermal management systems,whic...; 关键词：Phase change film Multifunctional material Energy storage SELF-HEALING RECYCLABILITY

Spatiotemporal responsive hydrogel microspheres for the treatment of gastric cancer: 《Aggregate》2024年第5期445-453,共9页Li Wang Lu Fan Anne M.Filppula Yu Wang Luoran Shang Hongbo Zhang; National Natural Science Foundation of China,Grant/Award Number:82372145;Research Fellow,Grant/Award Number:353146;Research Project,Grant/Award Number:347897;Solutions for Health Proﬁle,Grant/Award Number:336355;InFLAMES Flagship,Grant/Award Number:337531;Finland China Food and Health International Pilot project funded by Finnish MInistry of Education and Culture。; The development of tumor drug microcarriers has attracted considerable interest due to their distinctive therapeutic performances.Current attempts tend to elab-orate on the micro/nano-structure design of the microcarr...; 关键词：combination therapy gastric cancer inverse opal MICROCARRIERS spatiotemporal responsiveness

Infection-responsive polysaccharide-based drug-loaded nano-assembly for dual-modal treatment against drug-resistant bacterial lung infection: 《BMEMat(BioMedical Engineering Materials)》2024年第3期123-136,共14页Lin Han Zhonghua Yuan Hui-Min Ren Weizhuo Song Ruonan Wu Jie Li Zhaoyan Guo Bingran Yu Shun Duan Fu-Jian Xu; Beijing Outstanding Young Scientist Program,Grant/Award Number:BJJWZYJH01201910010024;National Natural Science Foundation of China,Grant/Award Numbers:52073024,52122304,52221006,52293382;Beijing Municipal Science and Technology Project,Grant/Award Number:Z191100006619099。; The escalating issue of lung infections induced by multi-drug resistant(MDR)bacteria is threatening human health.Thus,the development of efficient drug delivery systems is essential to eliminate MDR bacterial lung inf...; 关键词：ANTIBACTERIAL infection responsiveness multi-drug resistant bacteria NANO-ASSEMBLY POLYSACCHARIDE

Electric vehicle optimal scheduling method considering charging piles matching based on edge intelligence: 《iEnergy》2024年第3期152-161,共10页Ning Guo Tuo Ji Xiaolong Xiao Tiankui Sun Jinming Chen Xiaoxing Lu Xinyi Zheng Shufeng Dong; supported by the Science and Technology Project of State Grid Jiangsu Electric Power Company(J2023114).; To adress the problems of insufficient consideration of charging pile resource limitations,discrete-time scheduling methods that do not meet the actual demand and insufficient descriptions of peak-shaving response cap...; 关键词：Edge intelligence electric vehicle charging pile optimal scheduling matching relationship peak shaving responsiveness

Utilizing dual-responsive iridium(Ⅲ) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy: 《Chinese Chemical Letters》2024年第9期296-302,共7页Jinyu Guo Yandai Lin Shaohua He Yueqing Chen Fenglu Li Renjie Ruan Gaoxing Pan Hexin Nan Jibin Song Jin Zhang; supported by the National Key R&D Program of China(Nos.2022YFB3808000,2022YFB3808001);the Project for High-Level Talent Innovation and Entrepreneurship of Quanzhou(No.2022C016R);the Medical Innovation Project of Science and Technology Program of Fujian Provincial Health Commission(No.2021CXA006);the Key Program of Qingyuan Innovation Laboratory(No.00221002).; Stimuli-triggered release and alleviating resistance of iridium(Ⅲ)-based drugs at tumor sites remains challengeable for clinical hepatoma therapy.Herein,a doxorubicin@iridium-transferrin(DOX@Ir-TF)nanovesicle was syn...; 关键词：Amphiphilic iridium complex Transferrin targeting NIR/GSH dual-responsiveness Photoacoustic imaging Synergistic tumor therapy

Cross-sectional analysis of blood leukocyte responsiveness to interleukin-10 and interleukin-6 across age and physical activity level: 《Translational Exercise Biomedicine》2024年第3期255-263,共9页Hashim Islam Jordan Boultbee Garett S.Jackson Alice L.Mui Jonathan P.Little; H.I.was supported by a Natural Sciences and Engineering Council(NSERC)postdoctoral fellowship and a Michael Smith Health Research BC Research Trainee Award;J.B.was supported by and NSERC Undergraduate Student Research Award;G.S.J.was supported by an Indigenous Scholar’s Award;J.P.L is supported by an NSERC Discovery Grant(RGPIN-2019-05204);Killam Accelerator Research Fellowship(AWD-018101).; Objectives To determine how the anti-inflammatory actions of interleukin-10(IL-10)and IL-6 differ across age and physical activity levels.Methods Using a cross-sectional design,fasted blood samples were obtained from ...; 关键词：chronic inflammation MONOCYTES lymphocytes STAT3 INFLAMMAGING exercise

Responsiveness of functional performance and muscle strength,power,and size to resistance training:A systematic review: 《Sports Medicine and Health Science》2024年第2期111-122,共12页Tome Edson dos Reis Moda Ricardo Borges Viana Rayra Khalinka Neves Dias Eduardo Macedo Penna Victor Silveira Coswig; There is a recent and growing interest in assessing differential responders to resistance training(RT)for diverse outcomes.Thus,the individual ability to respond to an intervention for a specific measurement,called re...; 关键词：Strength training HETEROGENEITY Muscle strength Skeletal muscle Functional performance Inter-individual variation Biological individuality

Dynamic compliance of energy-saving legged elastic parallel joints for quadruped robots:design and realization: 《Frontiers of Mechanical Engineering》2024年第2期45-58,共14页Yaguang ZHU Minghuan ZHANG Xiaoyu ZHANG Haipeng QIN; supported in part by the National Natural Science Foundation of China(Grant No.62373064);in part by the State Key Laboratory of Robotics and Systems,Harbin Institute of Technology,China(Grant No.SKLRS-2023-KF-05);in part by the Fundamental Research Funds for Central Universities,China(Grants Nos.300102259308,300102259401).; Achieving dynamic compliance for energy-efficient legged robot motion is a longstanding challenge.Although recent predictive control methods based on single-rigid-body models can generate dynamic motion,they all assum...; 关键词：dynamic responsiveness energy dissipation legged locomotion parallel joints quadruped robot

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