MONOCYTES

作品数：165被引量：689H指数：13
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Impaired efferocytosis by monocytes and monocyte-derived macrophages in patients with poorly controlled type 2 diabetes
《World Journal of Diabetes》2025年第5期283-296,共14页Qian-Yun Mao Hui Ran Qiu-Yue Hu Sun-Yue He Yao Lu Han Li Yi-Meng Chai Zhao-Yin Chu Xu Qian Wan Ding Yi-Xin Niu Hong-Mei Zhang Xiao-Yong Li Qing Su 
Supported by National Natural Science Foundation of China,No.81970669,No.82170835,and No.82100848;Shanghai Municipal Health Commission,No.202240107,and No.20234Y0040;China Endocrine Metabolism Research Program of Excellence,No.2023-N-03-05。
BACKGROUND Deficient efferocytosis(i.e.,phagocytic clearance of apoptotic cells)by macrophages has been frequently reported in experimental models of type 2 diabetes(T2D).AIM To translate these findings to humans by t...
关键词：Type 2 diabetes EFFEROCYTOSIS MONOCYTE MACROPHAGE 
Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies
《Neural Regeneration Research》2025年第3期779-793,共15页Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou Hua 
supported by the National Natural Science Foundation of China,Nos.82060219,82271234;the Natural Science Foundation of Jiangxi Province,Nos.20212ACB216009,20212BAB216048;Jiangxi Province Thousands of Plans,No.jxsq2019201023;Youth Team Project of the Second Affiliated Hospital of Nanchang University,No.2019YNTD12003(all to FH)。
Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple rol...
关键词：blood–brain barrier MACROPHAGES MONOCYTES multiple sclerosis NEUROINFLAMMATION review therapy 
CCL2-CCR2 axis in cardiovascular disease:research advances and challenges
《Science Bulletin》2025年第6期820-824,共5页Yang Yang Jiayan Li Jiayou Tang Bo Wang Jing Wang Xuezeng Xu Wangrui Lei Ying Cheng Liwen Liu 
supported by the National Natural Science Foundation of China(82270526,82070422,82200330,82071932,82371974,and 82272009);Key Medical Research Projects in Xi’an City(24YXYJ0010);Shaanxi Province Traditional Chinese Medicine Research and Innovation Talent Project(TZKN-CXRC-06);Research Plan Project of Shaanxi Institute of Basic Science(22JHQ053);Qinchuangyuan Traditional Chinese Medicine Innovation Research and Development Transformation Project(2022-QCYZH-036).
C-C motif chemokine ligand 2(CCL2)is a member of the chemokine family and is also known as monocyte chemoattractant protein-1.It is a crucial factor for regulating the migration and infiltration of various immune cell...
关键词：monocyte chemoattractant protein chemokine family cardiovascular disease CCL immune cells migration infiltration c chemokine ligand MONOCYTES 
Features of the monocyte inflammatory response in patients with premature coronary artery disease
《Biophysics Reports》2025年第1期12-17,共6页Tatiana Blokhina Tatiana Kirichenko Yuliya Markina Ulyana Khovantseva Ivan Melnikov Olga Guseva Sergey Bazanovich Sergey Kozlov Alexander Orekhov 
supported by Russian Science Foundation(22-15-00134)。
The purpose of this study was to examine the secretion of inflammatory cytokines by cultured monocytes/macrophages in patients with premature coronary artery disease(CAD).The study included 38patients with premature C...
关键词：Coronary artery disease MONOCYTES Inflammatory cytokines Immune tolerance 
Immune indicators and depression in adolescents:Associations with monocytes,lymphocytes,and direct bilirubin
《World Journal of Psychiatry》2025年第2期23-32,共10页Jian Dai Xiao-Tong Lin Lu-Lu Shen Xi-Wen Zhang Zi-Wen Ding Jing Wang Xi-Wang Fan Wei-Dong Ning 
Supported by the Medical Discipline Construction Project of Pudong Health Committee of Shanghai,No.PWZzb2022-09;Nanning City Science Research and Technology Development Program,No.ZC20233017;and Guangxi Medical and Health Appropriate Technology Development and Promotion Project,No.S2021061.
BACKGROUND Depression is a significant psychiatric disorder with particularly high prevalence among adolescents.This mental health condition can have severe consequences,including academic failure,social withdrawal,an...
关键词：DEPRESSION Adolescents Immune markers MONOCYTE LYMPHOCYTE Direct bilirubin 
Development of a novel HER2-CAR monocyte cell therapy with controllable proliferation and enhanced anti-tumor efficacy被引量：1
《Chinese Medical Journal》2024年第21期2590-2602,共13页Bing Yang Xiaoxue Wang Xundong Wei Jie Ma 
supported by the National High-Level Hospital Clinical Research Funding(No.BJ-2022-118);CAMS Innovation Fund for Medical Sciences(No.2021-1-I2M-050);National Natural Science Foundation of China(Nos.52273281 and 82173109);Guangxi Science and Technology Base and Talent Special Projects(No.AD21220001).
Background:One of the significant challenges for cell therapies,such as chimeric antigen receptor(CAR)-T cell therapy,is the poor infiltration of immune cells into tumor tissues.CAR-monocytes/macrophages(CAR-M)are pro...
关键词：Receptors chimeric antigen Macrophages MONOCYTES Cell suicide Antibody-dependent cell phagocytosis METALLOPROTEINASES 
Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node被引量：1
《Cellular & Molecular Immunology》2024年第9期999-1007,共9页Carolina R.Melo-Silva Luis J.Sigal 
The interstitial fluids in tissues are constantly drained into the lymph nodes(LNs)as lymph through afferent lymphatic vessels and from LNs into the blood through efferent lymphatics.LNs are strategically positioned a...
关键词：Virus infection lymph borne virus lymph node virus control innate immunity adaptive immunity dendritic cells Langerhans cells macrophages inflammatory monocytes natural killer cells CD8+T-cells 
Cross-sectional analysis of blood leukocyte responsiveness to interleukin-10 and interleukin-6 across age and physical activity level
《Translational Exercise Biomedicine》2024年第3期255-263,共9页Hashim Islam Jordan Boultbee Garett S.Jackson Alice L.Mui Jonathan P.Little 
H.I.was supported by a Natural Sciences and Engineering Council(NSERC)postdoctoral fellowship and a Michael Smith Health Research BC Research Trainee Award;J.B.was supported by and NSERC Undergraduate Student Research Award;G.S.J.was supported by an Indigenous Scholar’s Award;J.P.L is supported by an NSERC Discovery Grant(RGPIN-2019-05204);Killam Accelerator Research Fellowship(AWD-018101).
Objectives To determine how the anti-inflammatory actions of interleukin-10(IL-10)and IL-6 differ across age and physical activity levels.Methods Using a cross-sectional design,fasted blood samples were obtained from ...
关键词：chronic inflammation MONOCYTES lymphocytes STAT3 INFLAMMAGING exercise 
Identification of potential immune-related mechanisms related to the development of multiple myeloma
《Chinese Medical Journal》2024年第13期1603-1613,共11页Yaomei Wang Wenli Zhang Tiandong Li Mengmeng Liu Mengya Gao Xinqing Li Yufei Chen Yongping Song Wei Li Chunyan Du Fang Wang Lina Liu 
Natural Science Foundation of China(No.81900108);Henan Province Young and Middle-aged Health Science and Technology Innovation Outstanding Young Talent Training Project(No.YXKC2022049);Henan Medical Science and Technology Research Program(No.SBGJ202002024)
Background:Although significant advances have been made in the treatment of multiple myeloma(MM),leading to unprecedented response and survival rates among patients,the majority eventually relapse,and a cure remains e...
关键词：Multiple myeloma Monocytes/macrophages Single-cell RNA sequencing Immune cell MICROENVIRONMENT Bone marrow Molecular characterization 
Celastrol inhibits inflammatory factors expression in glioblastoma
《Traditional Medicine Research》2024年第6期1-11,共11页Na Qin Shu-Xian Yang Shi-Man Gao Ting Zhu 
supported by the National Natural Science Foundation of China(No.82204663);the Natural Science Foundation of Shandong Province(No.ZR2022QH058).
Background:Glioblastoma is one of the most common primary intracranial tumors of the central nervous system in adults.Although chemotherapy is an important component of glioblastoma treatment,its effectiveness remains...
关键词：GLIOBLASTOMA monocytes/macrophages single-cell RNA sequencing MIF/CD74 signaling pathway CELASTROL 
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