INFLAMMAGING

作品数:14被引量:22H指数:3
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相关期刊:《Genomics, Proteomics & Bioinformatics》《Life Metabolism》《Military Medical Research》《Cellular & Molecular Immunology》更多>>
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Mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration
《Neural Regeneration Research》2025年第3期805-807,共3页JoséM.Izquierdo 
supported by the Ministry of Science and Innovation and the Spanish Research Agency through FEDER funds (PID2021-1261520B-100) (MICINN/AEI/FEDER, EU);CBM receives an institutional grant from the Fundación Ramón Areces, Spain。
The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre...
关键词:LATIN POTENTIAL lasting 
Immune aging and infectious diseases
《Chinese Medical Journal》2024年第24期3010-3049,共40页Ruochan Chen Ju Zou Jiawang Chen Ling Wang Rui Kang Daolin Tang 
supported by grants from the National Natural Sciences Foundation of China(Nos.82070613 and 82370638);the Science and Technology Innovation Program of Hunan Province(No.2022RC1212);the Natural Science Foundation of Hunan Province China(Nos.2023JJ10095 and 2021JJ70146).
The rise in global life expectancy has led to an increase in the older population,presenting significant challenges in managing infectious diseases.Aging affects the innate and adaptive immune systems,resulting in chr...
关键词:AGING Infectious diseases IMMUNOSENESCENCE INFLAMMAGING 
Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: the risk of senescent drift induction in secretome-based therapeutics
《Military Medical Research》2024年第5期792-793,共2页Anna Smirnova Elena Yatsenko Denis Baranovskii Ilya Klabukov 
Regulatory changes in senescent cells could potentially affect the composition of extracellular vehicles(EVs),specifically altering their size and cargo.As a result,the released senescent EVs contain an unpredictable ...
关键词:Cell therapy INFLAMMAGING SECRETOME SENESCENCE 
Cross-sectional analysis of blood leukocyte responsiveness to interleukin-10 and interleukin-6 across age and physical activity level
《Translational Exercise Biomedicine》2024年第3期255-263,共9页Hashim Islam Jordan Boultbee Garett S.Jackson Alice L.Mui Jonathan P.Little 
H.I.was supported by a Natural Sciences and Engineering Council(NSERC)postdoctoral fellowship and a Michael Smith Health Research BC Research Trainee Award;J.B.was supported by and NSERC Undergraduate Student Research Award;G.S.J.was supported by an Indigenous Scholar’s Award;J.P.L is supported by an NSERC Discovery Grant(RGPIN-2019-05204);Killam Accelerator Research Fellowship(AWD-018101).
Objectives To determine how the anti-inflammatory actions of interleukin-10(IL-10)and IL-6 differ across age and physical activity levels.Methods Using a cross-sectional design,fasted blood samples were obtained from ...
关键词:chronic inflammation MONOCYTES lymphocytes STAT3 INFLAMMAGING exercise 
Physical activity and cardiometabolic risk factors in sprint and jump-trained masters athletes,young athletes and non-physically active men
《Translational Exercise Biomedicine》2024年第3期244-254,共11页Jörn Rittweger Wolfram Sies Miriam Capri Dominik Pesta 
funded with internal funding from the DLR.
Objectives Assessing physical activity and cardiometabolic risk in masters athletes as an example of very high physical activity at old age.Methods Forty-three men were studied in full factorial design,either as sprin...
关键词:INFLAMMAGING cardiovascular health exercise training track and field athletics aging 
Impact of immunosenescence and inflammaging on the effects of immune checkpoint inhibitors被引量:3
《Cancer Pathogenesis and Therapy》2024年第1期24-30,共7页Chuandong Hou Zining Wang Xuechun Lu 
This work was supported by the National Key Research and Development Program of China(No.2020YFC2002706);the Key Military Health Project(No.23BJZ25).
Immune checkpoint inhibitors(ICIs)are employed in immunotherapeutic applications for patients with weakened immune systems and can improve the ability of T cells to kill cancer cells.Although ICIs can potentially trea...
关键词:IMMUNOSENESCENCE INFLAMMAGING Immune checkpoint inhibitor 
Taurine as a possible therapy for immunosenescence and inflammaging被引量:1
《Cellular & Molecular Immunology》2024年第1期3-5,共3页JoséM.Izquierdo 
supported by the Ministry of Science and Innovation and the Spanish Research Agency through FEDER funds(PID2021-1261520B-100)(MICINN/AEI/FEDER,EU).
In their recent Science article,Singh et al.identified taurine as an endogenously produced anti-inflammatory,anti-immunosenescence,and anti-aging molecule.The authors also show that restoring taurine to its“youthful...
关键词:TAURINE inflam 
Metabolic reprogramming in inflammaging and aging in T cells
《Life Metabolism》2023年第5期17-24,共8页Alessio Bevilacqua Ping-Chih Ho Fabien Franco 
P.C.H.was supported in part by the Helmut Horten Foundation,the Anna Fuller Grant,the Cancer Research Institute Llyod J.OLD STAR Investigator award,the Melanoma Research Alliance Established Investigator Award,Ludwig Cancer Research,and the University of Lausanne.
Aging represents an emerging challenge for public health due to the declined immune responses against pathogens, weakened vaccination efficacy, and disturbed tissue homeostasis. Metabolic alterations in cellular and s...
关键词:immunometabolism INFLAMMAGING T cells 
Estrogen rapid effects:a window of opportunity for the aging brain?
《Neural Regeneration Research》2022年第8期1629-1632,共4页Ivanny Marchant Jana Stojanova Lilian Acevedo Pablo Olivero 
Estrogen produces several beneficial effects in healthy neurological tissues and exhibits cardioprotective effects.Hormone therapy has been widely used to treat menopausal estrogen deficiency for more than 80 years.De...
关键词:AGING cardiovascular prevention cognitive function ESTROGEN hormone treatment INFLAMMAGING rapid effects timing hypothesis TRPV1 window of opportunity 
Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging被引量:11
《International Journal of Oral Science》2021年第3期251-260,共10页Qian Wang Lulingxiao Nie Pengfei Zhao Xinyi Zhou Yi Ding Qianming Chen Qi Wang 
supported by the National Natural Science Foundation of China[Grant Numbers 81870779;81991500;81991502];the International Cooperation Project of Chengdu Municipal Science and Technology Bureau[Grant Number 2015-GH0200035-HZ]。
Hyperglycemia induces chronic low-grade inflammation(inflammaging),which is a newly identified contributor to diabetes-related tissue lesions,including the inflammatory bone loss in periodontitis.It is also a secondar...
关键词:ELEVATED MACROPHAGE LESIONS 
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