supported by the Ministry of Science and Innovation and the Spanish Research Agency through FEDER funds (PID2021-1261520B-100) (MICINN/AEI/FEDER, EU);CBM receives an institutional grant from the Fundación Ramón Areces, Spain。
The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre...
supported by grants from the National Natural Sciences Foundation of China(Nos.82070613 and 82370638);the Science and Technology Innovation Program of Hunan Province(No.2022RC1212);the Natural Science Foundation of Hunan Province China(Nos.2023JJ10095 and 2021JJ70146).
The rise in global life expectancy has led to an increase in the older population,presenting significant challenges in managing infectious diseases.Aging affects the innate and adaptive immune systems,resulting in chr...
Regulatory changes in senescent cells could potentially affect the composition of extracellular vehicles(EVs),specifically altering their size and cargo.As a result,the released senescent EVs contain an unpredictable ...
H.I.was supported by a Natural Sciences and Engineering Council(NSERC)postdoctoral fellowship and a Michael Smith Health Research BC Research Trainee Award;J.B.was supported by and NSERC Undergraduate Student Research Award;G.S.J.was supported by an Indigenous Scholar’s Award;J.P.L is supported by an NSERC Discovery Grant(RGPIN-2019-05204);Killam Accelerator Research Fellowship(AWD-018101).
Objectives To determine how the anti-inflammatory actions of interleukin-10(IL-10)and IL-6 differ across age and physical activity levels.Methods Using a cross-sectional design,fasted blood samples were obtained from ...
Objectives Assessing physical activity and cardiometabolic risk in masters athletes as an example of very high physical activity at old age.Methods Forty-three men were studied in full factorial design,either as sprin...
This work was supported by the National Key Research and Development Program of China(No.2020YFC2002706);the Key Military Health Project(No.23BJZ25).
Immune checkpoint inhibitors(ICIs)are employed in immunotherapeutic applications for patients with weakened immune systems and can improve the ability of T cells to kill cancer cells.Although ICIs can potentially trea...
supported by the Ministry of Science and Innovation and the Spanish Research Agency through FEDER funds(PID2021-1261520B-100)(MICINN/AEI/FEDER,EU).
In their recent Science article,Singh et al.identified taurine as an endogenously produced anti-inflammatory,anti-immunosenescence,and anti-aging molecule.The authors also show that restoring taurine to its“youthful...
P.C.H.was supported in part by the Helmut Horten Foundation,the Anna Fuller Grant,the Cancer Research Institute Llyod J.OLD STAR Investigator award,the Melanoma Research Alliance Established Investigator Award,Ludwig Cancer Research,and the University of Lausanne.
Aging represents an emerging challenge for public health due to the declined immune responses against pathogens, weakened vaccination efficacy, and disturbed tissue homeostasis. Metabolic alterations in cellular and s...
Estrogen produces several beneficial effects in healthy neurological tissues and exhibits cardioprotective effects.Hormone therapy has been widely used to treat menopausal estrogen deficiency for more than 80 years.De...
supported by the National Natural Science Foundation of China[Grant Numbers 81870779;81991500;81991502];the International Cooperation Project of Chengdu Municipal Science and Technology Bureau[Grant Number 2015-GH0200035-HZ]。
Hyperglycemia induces chronic low-grade inflammation(inflammaging),which is a newly identified contributor to diabetes-related tissue lesions,including the inflammatory bone loss in periodontitis.It is also a secondar...