IMMUNOSENESCENCE

作品数：25被引量：95H指数：5
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相关领域：医药卫生农业科学更多>>
相关作者：曹湘博更多>>
相关机构：中国医学科学院北京协和医学院吉林大学更多>>
相关期刊：《Cellular & Molecular Immunology》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《Phenomics》更多>>
相关基金：国家自然科学基金国家教育部博士点基金国家重点基础研究发展计划高等学校学科创新引智计划更多>>
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Immune aging and infectious diseases
《Chinese Medical Journal》2024年第24期3010-3049,共40页Ruochan Chen Ju Zou Jiawang Chen Ling Wang Rui Kang Daolin Tang 
supported by grants from the National Natural Sciences Foundation of China(Nos.82070613 and 82370638);the Science and Technology Innovation Program of Hunan Province(No.2022RC1212);the Natural Science Foundation of Hunan Province China(Nos.2023JJ10095 and 2021JJ70146).
The rise in global life expectancy has led to an increase in the older population,presenting significant challenges in managing infectious diseases.Aging affects the innate and adaptive immune systems,resulting in chr...
关键词：AGING Infectious diseases IMMUNOSENESCENCE INFLAMMAGING 
PMN-MDSC:A Culprit Behind Immunosenescence and Increased Susceptibility to Clostridioides difficile Infection During Aging
《Engineering》2024年第11期59-73,共15页Jianmin Wu Ming Zhang Hao Zhang Mingxuan Sheng Jiazeng Sun Fang Wu Haina Gao Lishui Chen Zhili Li Qiyu Tian Longjiao Zhu Bing Fang 
supported by the National Key Research and Development Program of China(2022YFF1100504);the 111 project from the Education Ministry of China(B18053);the National Natural Science Foundation of China(32101938 and 32302758);the China Postdoctoral Science Foundation(2022M723422);the Postdoctoral Fellowship Program of CPSF(GZB20230848).
Susceptibility to pathogens in the elderly is heightened with age,largely because of immunosenescence.As an immune regulatory organ,bone marrow creates immune cells that move to other organs and tis-sues through the b...
关键词：PMN-MDSC IMMUNOSENESCENCE AGING Mass cytometry Clostridioides difficile 
The role and research progress of MDSC in immune aging-related diseases
《Biomedical Engineering Communications》2024年第2期4-9,共6页Xi-Xing Fang Han-Zhou Li Xue-Mei Piao Yu-Ming Wang Yu-Hong Bian 
supported by S&T Program of Hebei(No.23379902L).
Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous immature cells with a strong immunosuppressive function in myeloid cells,which are impeded in the differentiation of myeloid cells under the patholog...
关键词：MDSC IMMUNOSENESCENCE tumor progression pulmonary fibrosis immunosenescence therapy 
Impact of immunosenescence and inflammaging on the effects of immune checkpoint inhibitors被引量：3
《Cancer Pathogenesis and Therapy》2024年第1期24-30,共7页Chuandong Hou Zining Wang Xuechun Lu 
This work was supported by the National Key Research and Development Program of China(No.2020YFC2002706);the Key Military Health Project(No.23BJZ25).
Immune checkpoint inhibitors(ICIs)are employed in immunotherapeutic applications for patients with weakened immune systems and can improve the ability of T cells to kill cancer cells.Although ICIs can potentially trea...
关键词：IMMUNOSENESCENCE INFLAMMAGING Immune checkpoint inhibitor 
Taurine as a possible therapy for immunosenescence and inflammaging被引量：1
《Cellular & Molecular Immunology》2024年第1期3-5,共3页JoséM.Izquierdo 
supported by the Ministry of Science and Innovation and the Spanish Research Agency through FEDER funds(PID2021-1261520B-100)(MICINN/AEI/FEDER,EU).
In their recent Science article,Singh et al.identified taurine as an endogenously produced anti-inflammatory,anti-immunosenescence,and anti-aging molecule.The authors also show that restoring taurine to its“youthful...
关键词：TAURINE inflam 
The immunomodulatory effects of bone marrow-derived mesenchymal stem cells on lymphocyte in spleens of aging rats
《Biomedical Engineering Communications》2023年第3期1-6,共6页Zhi-Hong Wang Zhi-Feng Lin Yi-Ting Lai Ling-Ling Ding Huai-Cheng Wang Xing Chen Xiao-Ye Chen Hua-Ke Zeng 
supported by joint funds for the innovation of science and technology,Fujian province(2020Y9027);Fujian Natural Science Foundation(2020J011062);Medical Innovation Project of Fujian Provincial Health Commission(2021CXA004).
Objective:To investigate the effects of bone marrow-derived mesenchymal stem cells(BMSCs)on the proliferation and secretion of IgM,IgG and IL-2 in spleen lymphocytes(L)of aging rats.Methods:BMSCs were isolated by the ...
关键词：bone marrow-derived mesenchymal stem cell IMMUNOSENESCENCE LYMPHOCYTE IMMUNOMODULATION 
Immune‑Ageing Evaluation of Peripheral T and NK Lymphocyte Subsets in Chinese Healthy Adults被引量：5
《Phenomics》2023年第4期360-374,共15页Zhenghu Jia Zhiyao Ren Dongmei Ye Jiawei Li Yan Xu Hui Liu Ziyu Meng Chengmao Yang Xiaqi Chen Xinru Mao Xueli Luo Zhe Yang Lina Ma Anyi Deng Yafang Li Bingyu Han Junping Wei Chongcheng Huang Zheng Xiang Guobing Chen Peiling Li Juan Ouyang Peisong Chen Oscar Junhong Luo Yifang Gao Zhinan Yin 
supported by National Key Research and Development Program of China(2020YFA0803502 to Z.Y.);National Natural Science Foundation of China(32030036 and 31830021 to Z.Y.);the 111 Project(B16021 to Z.Y.);Natural Science Foundation of China(81971301 and 32050410285 to O.J.L.);Guangzhou Planned Project of Science and Technology(202002020039 to O.J.L.);Guangdong Basic and Applied Basic Research Foundation(2021A1515110734 to Z.R.);Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,China(2013A061401007,2017B030314018,2020B1212060026);Guangdong Provincial International Cooperation Base of Science and Technology(Organ Transplantation);The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,China(2015B050501002,2020A0505020003).
Ageing is often accompanied with a decline in immune system function,resulting in immune ageing.Numerous studies have focussed on the changes in different lymphocyte subsets in diseases and immunosenescence.The change...
关键词：IMMUNOSENESCENCE PHENOTYPE T cell subset Natural killer cell subsets Immune-ageing modelling 
Immunosenescence:molecular mechanisms and diseases被引量：19
《Signal Transduction and Targeted Therapy》2023年第6期2671-2686,共16页Zaoqu Liu Qimeng Liang Yuqing Ren Chunguang Guo Xiaoyong Ge Libo Wang Quan Cheng Peng Luo Yi Zhang Xinwei Han 
Infection susceptibility,poor vaccination efficacy,age-related disease onset,and neoplasms are linked to innate and adaptive immune dysfunction that accompanies aging(known as immunosenescence).During aging,organisms ...
关键词：METABOLISM NEOPLASMS alterations 
Sialic acid-mediated photochemotherapy enhances infiltration of CD8^(+)T cells from tumor-draining lymph nodes into tumors of immunosenescent mice被引量：2
《Acta Pharmaceutica Sinica B》2023年第1期425-439,共15页Dezhi Sui Changzhi Li Xueying Tang Xianmin Meng Junqiang Ding Qiongfen Yang Zhaowei Qi Xinrong Liu Yihui Deng Yanzhi Song 
supported by the National Natural Science Foundation of China(Grant Nos.81973271,81703456,and 81573375);the Career Development Plan for Young and Middle-aged Teachers of Shenyang Pharmaceutical University(ZQN2021009,China)。
Immunoscenescence plays a key role in the initiation and development of tumors.Furthermore,immunoscenescence also impacts drug delivery and cancer therapeutic efficacy.To reduce the impact of immunosenescence on anti-...
关键词：IMMUNOSENESCENCE Sialic acid PHOTOCHEMOTHERAPY CD8^(+)T cells DOXORUBICIN NEUTROPHILS Indocyanine green Liposomes 
Common spices & yoga as incredible medicines for geriatric care during COVID-19
《TMR Aging》2021年第1期35-43,共9页Divya Kajaria Tanuja Nesari 
Geriatric care during coronavirus disease 2019 is a real concern for all countries whether it is developed or developing.Poor tolerability for conventional medicines,co-morbidities,weak immune system,high oxidative st...
关键词：IMMUNOSENESCENCE YOGA Suryanamskara Kitchen spices 
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