The role and research progress of MDSC in immune aging-related diseases  

作　　者：Xi-Xing Fang Han-Zhou Li Xue-Mei Piao Yu-Ming Wang Yu-Hong Bian 

机构地区：[1]Medical School,Hubei Minzu University,Enshi 445099,China [2]College of Integrative Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [3]Nursing Department,People's Hospital of Longjing City,Longjing 133499,China

出　　处：《Biomedical Engineering Communications》2024年第2期4-9,共6页生物医学工程通讯

基　　金：supported by S&T Program of Hebei(No.23379902L).

摘　　要：Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous immature cells with a strong immunosuppressive function in myeloid cells,which are impeded in the differentiation of myeloid cells under the pathological conditions of hypoxia,inflammation,infection,and cancer.As individuals age,there is a significant increase in myeloid-derived suppressor cells(MDSCs),which subsequently enhance the immunosuppressive functions of Tregs(regulatory T cells)and Bregs(regulatory B cells).Therefore,MDSC may be related to immune system remodeling,thereby preventing excessive lesions caused by aging.This indicates that MDSC could serve as a potent inducer of immune senescence.Immune senescence,characterized by immune dysfunction with aging,is closely linked to the onset of diseases like infections,pulmonary fibrosis,and tumors.To achieve the purpose of anti-aging by intervening in immune aging and slow down the occurrence and development of related diseases.Therefore,understanding the biological characteristics of MDSC and its role in immune aging is crucial for immunotherapy targeting MDSC.This article reviews the different roles of MDSC in immune aging and its relationship with pulmonary fibrosis,tumor and other related diseases to provide theoretical basis for more comprehensive targeted MDSC immunotherapy.

关 键 词：MDSC IMMUNOSENESCENCE tumor progression pulmonary fibrosis immunosenescence therapy 

分 类 号：R73[医药卫生—肿瘤]