Immunosenescence:molecular mechanisms and diseases  

作　　者：Zaoqu Liu Qimeng Liang Yuqing Ren Chunguang Guo Xiaoyong Ge Libo Wang Quan Cheng Peng Luo Yi Zhang Xinwei Han 

机构地区：[1]Department of Interventional Radiology,The First Affiliated Hospital of Zhengzhou University,450052,Zhengzhou,Henan,China [2]Interventional Institute of Zhengzhou University,450052,Zhengzhou,Henan,China [3]Interventional Treatment and Clinical Research Center of Henan Province,450052,Zhengzhou,Henan,China [4]Nephrology Hospital,the First Affiliated Hospital of Zhengzhou University,Zhengzhou University,4500052,Henan,China [5]Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital of Zhengzhou University,450052,Zhengzhou,Henan,China [6]Department of Endovascular Surgery,The First Affiliated Hospital of Zhengzhou University,450052,Zhengzhou,Henan,China [7]Department of Hepatobiliary and Pancreatic Surgery,The First Affiliated Hospital of Zhengzhou University,450052,Zhengzhou,Henan,China [8]Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha,China [9]Department of Oncology,Zhujiang Hospital,Southern Medical University,Guangzhou,China [10]Biotherapy Center and Cancer Center,The First Affiliated Hospital of Zhengzhou University,450052,Zhengzhou,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第6期2671-2686,共16页信号转导与靶向治疗（英文）

摘　　要：Infection susceptibility,poor vaccination efficacy,age-related disease onset,and neoplasms are linked to innate and adaptive immune dysfunction that accompanies aging(known as immunosenescence).During aging,organisms tend to develop a characteristic inflammatory state that expresses high levels of pro-inflammatory markers,termed inflammaging.This chronic inflammation is a typical phenomenon linked to immunosenescence and it is considered the major risk factor for age-related diseases.Thymic involution,naïve/memory cell ratio imbalance,dysregulated metabolism,and epigenetic alterations are striking features of immunosenescence.Disturbed T-cell pools and chronic antigen stimulation mediate premature senescence of immune cells,and senescent immune cells develop a proinflammatory senescence-associated secretory phenotype that exacerbates inflammaging.Although the underlying molecular mechanisms remain to be addressed,it is well documented that senescent T cells and inflammaging might be major driving forces in immunosenescence.Potential counteractive measures will be discussed,including intervention of cellular senescence and metabolic-epigenetic axes to mitigate immunosenescence.In recent years,immunosenescence has attracted increasing attention for its role in tumor development.As a result of the limited participation of elderly patients,the impact of immunosenescence on cancer immunotherapy is unclear.Despite some surprising results from clinical trials and drugs,it is necessary to investigate the role of immunosenescence in cancer and other age-related diseases.

关 键 词：METABOLISM NEOPLASMS alterations 

分 类 号：R730[医药卫生—肿瘤]