NEUTROPHILS

作品数：236被引量：940H指数：16
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相关作者：刘艳芳孙汭田志刚魏海明徐皓亮更多>>
相关机构：中国医学科学院北京协和医学院第二军医大学中国人民解放军第三〇二医院中国科学技术大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金中国博士后科学基金更多>>
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Bioactive materials from berberine-treated human bone marrow mesenchymal stem cells accelerate tooth extraction socket healing through the jaw vascular unit
《Science China(Life Sciences)》2025年第4期1025-1041,共17页Ruyu Wang Tianxiao Wang Ziyu Chen Jiandong Jiang Yifei Du Hua Yuan Yongchu Pan Yuli Wang 
supported by grants from the Jiangsu Province Capability Improvement Project through Science,Technology and Education-Jiangsu Provincial Research Hospital Cultivation Unit(YJXYYJSDW4);Jiangsu Provincial Medical Innovation Center(CXZX202227)。
Delayed tooth extraction socket(TES)healing can cause failure of subsequent oral implantation and increase socioeconomic burden on patients.Excessive amounts of M1 macrophages,apoptotic neutrophils(ANs),and neutrophil...
关键词：BERBERINE human bone marrow mesenchymal stem cells tooth extraction socket macrophages apoptotic neutrophils neutrophil extracellular traps 
Neutrophils:Key players in the metabolic syndrome puzzle
《hLife》2025年第3期121-131,共11页Hui Ping Yaw Sapna Devi Lai Guan Ng 
supported by the National Natural Science Foun-dation of China(grant number 92374205 and W2431020)to L.G.N。
Metabolic syndrome(MetS)is a group of metabolic abnormalities associated with an increased risk of getting type 2 diabetes mellitus(T2DM)and cardiovascular disease(CVD).For many years,MetS has been viewed solely as a ...
关键词：NEUTROPHILS adiposetissues INFLAMMATION metabolicsyndrome tissuereprogramming 
Metabolic Dysfunction-Associated Steatohepatitis Detected by Neutrophilic Crown-Like Structures in Morbidly Obese Patients:A Multicenter and Clinicopathological Study
《Research》2025年第1期320-332,共13页Mengqi Fan Erfei Song Yuying Zhang Pengfei Zhang Bing Huang Kaixuan Yan Wah Yang Subrata Chakrabarti Hema Mahajan Sen Yan Ying Xu Shuang Hua Wei Liu Cunchuan Wang Aimin Xu Dewei Ye 
financially supported by NSFC(82374171 and 81570701);the Natural Science Foundation of Guangdong Province(2024A1515012945);the Key Laboratory of Model Animal Phenotyping and Basic Research in Metabolic Diseases(2018KSYS003).
Metabolic dysfunction-associated steatohepatitis(MASH)is the progressive form of metabolic dysfunction-associated steatotic liver disease(MASLD),and closely associated with a high risk of liver-related morbidity and m...
关键词：hepatic neutrophils enhanced neutrophil infiltration neutrophilic crown structures morbidly obese clinicopathological study bariatric surgery 
Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms
《Cancer Communications》2025年第1期15-42,共28页Jiali Yao Linlin Ji Guang Wang Jin Ding 
National Natural Science Foundation of China,Grant/Award Numbers:82473431,82303184;Innovation Program of Shanghai Municipal Education Commission,Grant/Award Number:20230548;Shanghai Key Laboratory of Cell Engineering,Grant/Award Number:14DZ2272300;Medical Discipline Construction Project of Pudong Health Committee of Shanghai,Grant/Award Number:PWYgf2021-08。
Neutrophils are key mediators of the immune response and play essential roles in the development of tumors and immune evasion.Emerging studies indicate that neutrophils also play a critical role in the immunotherapy r...
关键词：immune resistance IMMUNOTHERAPY NEUTROPHIL tumor Tumor microenvironment 
Bis-5HT modified Paris Saponin II nanoparticles treat neutrophil infiltrating allergic rhinitis by regulating the alanine metabolism pathway
《Engineered Regeneration》2024年第4期452-467,共16页Wenwen Qi Lei Shi Xinhao Wu Fangyuan Zhu Zhenxiao Teng Xiaochen Gao Xin Bing Na Guo Xue Cao Chengzhilin Li Houyang Hu Fanyu Yuan Yuhan Dong Ming Xia Chengcheng Liu 
supported by grants from the National Natural Science Foundation of China(#82071013 and#82371118);Joint Fund of Shandong Province(#ZR2021LSW028);the National Natural Science Foundation of Shandong Province(#ZR2023MH106 and#ZR2023MH364);Taishan Scholar Foundation of Shandong Province(#tsqn201812134)。
Allergic rhinitis(AR)has emerged as a global concern,particularly due to the recent rise in disease incidence.There is an urgent need for safer,more effective,and shorter-term targeted immunotherapy approaches.Our pre...
关键词：Allergic rhinitis NEUTROPHILS Paris saponins II Metabolomics ALANINE 
Impact of negative pressure wound therapy on inflammatory cell counts in porcine deep dermal burn wound models
《Chinese Journal of Plastic and Reconstructive Surgery》2024年第4期166-171,共6页Giri Yurista Nabilah Anisa Novebri Irianiwati Muhammad Rosadi Seswandhan 
supported by the Community Fund Grant from the Faculty of Medicine,Public Health,and Nursing,Universitas Gadjah Mada,under the 2022 Scheme for Faculty-Postgraduate Medical Education Students(grant no.371/UN1/FKKMK/PPKE/PT/2022).
Background: The inflammatory phase of acute burns can last for 7 days. Meanwhile, severe burns may exhibit persistent inflammation long after the initial tissue damage. Negative pressure wound therapy(NPWT) is recomme...
关键词：Burn wounds LYMPHOCYTES Negative pressure wound therapy NEUTROPHILS Plasma cells Wound healing 
Spontaneous NETosis and type I IFN signaling activation in resting neutrophils of chronic granulomatous disease patients with CYBB mutations
《Genes & Diseases》2024年第6期8-11,共4页Zhengjing Lu Wenjun Mou Jianxin He Xuedong Ge Xiaolin Wang Jingang Gui 
supported by grants from the National Natural Science Foundation of China (No.82173084,82002637).
Mutations in CYBB,encoding gp91^(phox)subunit of NADPH oxidase in phagocytes,impair the respiratory burst of neutrophils and result in X-linked chronic granulomatous disease(CGD).While inflammatory response and NETosi...
关键词：NEUTROPHILS GRANULOMA RESPIRATORY 
Targeted nuclear degranulation of neutrophils promotes the progression of pneumonia in ulcerative colitis
《Precision Clinical Medicine》2024年第4期307-317,共11页Yiming Shao Qibing Zheng Xiaobei Zhang Ping Li Xingxin Gao Liming Zhang Jiahong Xu Lingchao Meng Yanyun Tian Qinqin Zhang Guangxi Zhou 
supported by grants from the National Natural Science Foundation of China(Grants No.82270562,82302800);China Postdoctoral Science Foundation(Grant No.2024M751108);Tai Shan Young Scholar Foundation of Shandong Province(Grant No.tsqn202103190);Postdoctoral Fund of The Affiliated Hospital of Jining Medical University(Grant No.JYFY364862);Postdoctoral Innovation Program in Shandong Province(Grant No.SDCX-ZG-202400032);Doctor Fund of The Affiliated Hospital of Jining Medical University(Grant No.2022-BS-07)。
Background:Both intestinal and pulmonary systems are parts of the mucosal immune system,comprising~80%of all immune cells.These immune cells migrate or are transported between various mucosal tissues to maintain tissu...
关键词：NEUTROPHILS targeted nuclear degranulation reverse migration ulcerative colitis PNEUMONIA 
Diabetes Primes Neutrophils for Neutrophil Extracellular Trap Formation through Trained Immunity
《Research》2024年第4期696-709,共14页Sanjeeb Shrestha Yu-Bin Lee Hoyul Lee Yeon-Kyung Choi Bo-Yoon Park Mi-Jin Kim Young-Jin Youn Sun-Hwa Kim Soo-Jung Jung Dong-Keun Song Hee Kyung Jin Jae-Sung Bae In-Kyu Lee Jae-Han Jeon Chang-Won Hong 
supported by National Research Foundation of Korea Grants 2022R1A2C2006898(to C.-W.H.);2020R1A4A2002691(to H.K.J.,J.-S.B.,and C.-W.H.);2020R1C1C1012729(to J.-H.J.);2021H1D3A2A01099688(to S.S.);Biomedical Research Institute Grant from Kyungpook National University Hospital(2018)and the Korean Health Industry Development Institute(KHIDI);funded by the Ministry of Health and Welfare,Republic of Korea(to J.-H.J.and C.-W.H.).
Neutrophils are primed for neutrophil extracellular trap(NET)formation during diabetes,and excessive NET formation from primed neutrophils compromises wound healing in patients with diabetes.Here,we demonstrate that t...
关键词：IMMUNITY HEALING inhibited 
Complex role of neutrophils in the tumor microenvironment: an avenue for novel immunotherapies
《Cancer Biology & Medicine》2024年第10期849-863,共15页Mao Zhang Haokai Qin Yingcheng Wu Qiang Gao 
supported by the National Natural Science Foundation of China(Grant Nos.82130077,81961128025,and 82121002);the Research Projects from the Science and Technology Commission of Shanghai Municipality(Grant Nos.21JC1401200,20JC1418900,and 21JC1410100)to QG,the China National Postdoctoral Program for Innovative Talents(Grant No.BX20240090);the China Postdoctoral Science Foundation(Grant No.2024M750551)to MZ.
Neutrophils,which originate from the bone marrow and are characterized by a segmented nucleus and a brief lifespan,have a crucial role in the body’s defense against infections and acute inflammation.Recent research h...
关键词：NEUTROPHIL PLASTICITY tumor microenvironment IMMUNOTHERAPY 
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