Complex role of neutrophils in the tumor microenvironment: an avenue for novel immunotherapies  

作　　者：Mao Zhang Haokai Qin Yingcheng Wu Qiang Gao 

机构地区：[1]Department of Liver Surgery and Transplantation,Liver Cancer Institute and Zhongshan Hospital,State Key Laboratory of Genetic Engineering,Human Phenome Institute,Fudan University,Shanghai 200433,China

出　　处：《Cancer Biology & Medicine》2024年第10期849-863,共15页癌症生物学与医学（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.82130077,81961128025,and 82121002);the Research Projects from the Science and Technology Commission of Shanghai Municipality(Grant Nos.21JC1401200,20JC1418900,and 21JC1410100)to QG,the China National Postdoctoral Program for Innovative Talents(Grant No.BX20240090);the China Postdoctoral Science Foundation(Grant No.2024M750551)to MZ.

摘　　要：Neutrophils,which originate from the bone marrow and are characterized by a segmented nucleus and a brief lifespan,have a crucial role in the body’s defense against infections and acute inflammation.Recent research has uncovered the complex roles of neutrophils as regulators in tumorigenesis,during which neutrophils exhibit a dualistic nature that promotes or inhibits tumor progression.This adaptability is pivotal within the tumor microenvironment(TME).In this review,we provide a comprehensive characterization of neutrophil plasticity and heterogeneity,aiming to illuminate current research findings and discuss potential therapeutic avenues.By delineating the intricate interplay of neutrophils in the TME,this review further underscores the urgent need to understand the dual functions of neutrophils with particular emphasis on the anti-tumor effects to facilitate the development of effective therapeutic strategies against cancer.

关 键 词：NEUTROPHIL PLASTICITY tumor microenvironment IMMUNOTHERAPY 

分 类 号：R730.51[医药卫生—肿瘤]