Bis-5HT modified Paris Saponin II nanoparticles treat neutrophil infiltrating allergic rhinitis by regulating the alanine metabolism pathway  

作　　者：Wenwen Qi Lei Shi Xinhao Wu Fangyuan Zhu Zhenxiao Teng Xiaochen Gao Xin Bing Na Guo Xue Cao Chengzhilin Li Houyang Hu Fanyu Yuan Yuhan Dong Ming Xia Chengcheng Liu 

机构地区：[1]Department of Otolaryngology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,China [2]Department of Otolaryngology,Shandong Provincial Hospital,Shandong University,Jinan,China [3]Department of Central Laboratory,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,China [4]Medical Science and Technology Innovation Center,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan,China [5]NHC Key Laboratory of Otorhinolaryngology,Jinan,China

出　　处：《Engineered Regeneration》2024年第4期452-467,共16页再生工程(英文)

基　　金：supported by grants from the National Natural Science Foundation of China(#82071013 and#82371118);Joint Fund of Shandong Province(#ZR2021LSW028);the National Natural Science Foundation of Shandong Province(#ZR2023MH106 and#ZR2023MH364);Taishan Scholar Foundation of Shandong Province(#tsqn201812134)。

摘　　要：Allergic rhinitis(AR)has emerged as a global concern,particularly due to the recent rise in disease incidence.There is an urgent need for safer,more effective,and shorter-term targeted immunotherapy approaches.Our previous studies have demonstrated the potential of paris saponins II in mitigating neutrophil infiltration in the nasal mucosa of AR mice.However,its clinical applicability has been hampered by limited by bio availability and bioactivity.In response to these limitations,we have developed bis-5HT-modified paris saponins II(designated as PLGA-5HT-PSII-Ce6)to target neutrophil-specific myeloperoxidase.Our verification,using metabolomics and other techniques,has affirmed the enhanced therapeutic efficacy of this targeted drug for allergic rhinitis.Further-more,the incorporation of photosensitizers has improved the treatment effect particularly when light induction is introduced.This development lead to promising prospects for the treatment of AR.

关 键 词：Allergic rhinitis NEUTROPHILS Paris saponins II Metabolomics ALANINE 

分 类 号：R76[医药卫生—耳鼻咽喉科]