Spontaneous NETosis and type I IFN signaling activation in resting neutrophils of chronic granulomatous disease patients with CYBB mutations  

作　　者：Zhengjing Lu Wenjun Mou Jianxin He Xuedong Ge Xiaolin Wang Jingang Gui 

机构地区：[1]Laboratory of Tumor Immunology,Key Laboratory of Major Diseases in Children,Ministry of Education,Beijing Pediatric Research Institute,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China [2]Department of Respiratory Medicine,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,China National Clinical Research Center for Respiratory Diseases,Beijing 100045,China [3]Information Center,PLA Rocket Force Characteristic Medical Center,Beijing 100088,China

出　　处：《Genes & Diseases》2024年第6期8-11,共4页基因与疾病（英文）

基　　金：supported by grants from the National Natural Science Foundation of China (No.82173084,82002637).

摘　　要：Mutations in CYBB,encoding gp91^(phox)subunit of NADPH oxidase in phagocytes,impair the respiratory burst of neutrophils and result in X-linked chronic granulomatous disease(CGD).While inflammatory response and NETosis are important modalities employed by neutrophils for pathogen clearance,variants in these cell functions in CGD neutrophils(CGD-PMN)could possibly explain the insufficient defense and accumulation of phagocytes in the sites of infection.

关 键 词：NEUTROPHILS GRANULOMA RESPIRATORY 

分 类 号：R73[医药卫生—肿瘤]