supported by Italian Ministry of Health Ricerca Corrente [RC 2023] and RF-2016-02361294;supported by#NEXTGENERATIONEU (NGEU);funded by the Ministry of University and Research (MUR);National Recovery and Resilience Plan (NRRP);project MNESYS (PE0000006)–A Multiscale integrated approach to the study of the nervous system in health and disease (DN. 1553 11.10.2022)(to FRG);partially supported by a grant from Fondazione Romeo ed Enrica Invernizzi (to FRG)。
Multiple sclerosis(MS) is a chronic, autoimmune and neuroinflammatory disease of the central nervous system(CNS) with a neurodegenerative component, characterized by demyelination and degeneration of nerve fibers. It ...
supported by a grant from the Japan Foundation for applied enzymology (to NT);the Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science (26430059, 17K08272, and 20K07014 to NT);the establishment of university fellowships toward the creation of science technology innovation (JPMJFS2128);a Grant-in-Aid for JSPS Fellows (23KJ1603)(to MK)。
The purpose of this perspective is to discuss the future development of a potential treatment of glial pathology in Alzheimer's disease(AD) and a new regulatory mechanism, nuclear lipids, which may be involved in the ...
supported by grants from the Next Generation EU-MUR D.M.737/2021-Project PSEBPEHRD-CUP B79J21038330001(to CRB)。
With increasing age,humans become more susceptible to the onset of neurodegenerative diseases(NDs),and among these,Alzheimer's disease(AD)is the most frequent(Nicoletti et al.,2023).NDs are primarily characterized by ...
supported by the National Natural Science Foundation of China,Nos.82001178(to LW),81901129(to LH),82001175(to FX);Shanghai Sailing Program,No.20YF1439200(to LW);the Natural Science Foundation of Shanghai,China,No.23ZR1450800(to LH);and the Fundamental Research Funds for the Central Universities,No.YG2023LC15(to ZX)。
Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal trafficking.However,it remains unclear whether protein ...
Animals exhibit complex responses to external and internal stimuli.The information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane potential.How can neuron...
Exosomes, a type of extracellular vesicle, are commonly found in different bodyfluids and are rich in nucleic acids (circRNA, lncRNAs, miRNAs, mRNAs, tRNAs, etc.), proteins,and lipids. They are involved in intercellul...
supported by the National Natural Science Foundation of China(Nos.42375171 and 42105157);the Interdisciplinary Research Project for Young Teachers of USTB(No.06600083);Energy Foundation(Nos.G-2109-33379 and G-2306-34754);the Fundamental Research Funds for the Central Universities(No.06500166).
Civil aviation is one of the industries facing the greatest challenge in reaching carbon neutrality by the middle of this century,and this sector also contributes to adverse impacts on the regional air quality and hum...
supported by the National Natural Science Foundation of China(No.42305109);Quzhou Municipal Science and Technology Bureau(No.2023K222).
Inhalation of atmospheric PM_(2.5)can induce the generation of excessive reactive oxygen species(ROS)in human alveoli,triggering local and systemic inflammation,which can directly or indirectly result in respiratory a...
jointly supported by the National Natural Science Foundation of China[grant numbers U2342202 and 42175005];the Qing Lan Project[grant number R2023Q06]。
In 2021,Cempaka,a tiny tropical cyclone,made landfall in China.As the TC intensified prior to landfall,the tropical cyclone size measured with precipitation decreased significantly.A numerical simulation was conducted...
supported by the Kunming University of Science and Technology“Double First-Class”Joint Special Project(Grant No.202101BE070001-011);Yunnan Fundamental Research Projects(202201BE070001-008,202201AT070192);National Natural Science Foundation of China(52402077);Shaanxi Province Key R&D Program(2021ZDLGY11-08);Open Project of Shaanxi Laboratory(2021SXsyS01-05);Open Project of Yunnan Precious Metals Laboratory(YPML-2023050240);National Natural Science Foundation of China(Grant No.52462009);Yunnan Fundamental Research Projects(Grant Nos.202201AT070192,202101BE070001-011).
The deep potential(DP)is an innovative approach based on deep learning that uses ab initio calculation data derived from density functional theory(DFT),to create high-accuracy potential functions for various materials...