PATHOLOGY

作品数:867被引量:2647H指数:23
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相关领域:医药卫生更多>>
相关作者:虞积耀董震王言言何晓徐艳萍更多>>
相关机构:华中科技大学天津医科大学四川大学华西医院第二军医大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划北京市自然科学基金广东省自然科学基金更多>>
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Potential treatment of Alzheimer's disease astrocyte pathology based on nuclear lipid regulation
《Neural Regeneration Research》2026年第1期322-323,共2页Masato Komai Nobumasa Takasugi 
supported by a grant from the Japan Foundation for applied enzymology (to NT);the Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science (26430059, 17K08272, and 20K07014 to NT);the establishment of university fellowships toward the creation of science technology innovation (JPMJFS2128);a Grant-in-Aid for JSPS Fellows (23KJ1603)(to MK)。
The purpose of this perspective is to discuss the future development of a potential treatment of glial pathology in Alzheimer's disease(AD) and a new regulatory mechanism, nuclear lipids, which may be involved in the ...
关键词:PATHOLOGY ALZHEIMER 
Role of resident memory T cells in neuroinflammatory and neurodegenerative diseases in the central nervous system
《Neural Regeneration Research》2025年第11期3227-3228,共2页Kimitoshi Kimura 
The immune system has been attracting increasing attention in the field of chronic neurological disorders in the central nervous system(CNS).Autoreactive T cells targeting CNS antigens play a crucial role in the devel...
关键词:DISEASES DEGENERATIVE PATHOLOGY 
Navigating the pathways:TAR-DNA-binding-protein-43 aggregation,axonal transport,and local synthesis in amyotrophic lateral sclerosis pathology
《Neural Regeneration Research》2025年第10期2921-2922,共2页Ori Bar Avi Eran Perlson 
Neurons are highly polarized cells with axons reaching over a meter long in adult humans.To survive and maintain their proper function,neurons depend on specific mechanisms that regulate spatiotemporal signaling and m...
关键词:SYNTHESIS LOCAL AGGREGATION 
Disruption of neuronal actin barrier promotes the entry of disease-implicated proteins to exacerbate amyotrophic lateral sclerosis pathology
《Neural Regeneration Research》2025年第9期2589-2590,共2页Mikio Shimizu Tatsusada Okuno 
supported in port by the JSPS KAKENHI(grant number 22K07539 to MS);funded by Mitsubishi Tanabe Pharma Corporation。
Amyotrophic lateral sclerosis(ALS)is a devastating neurological disease characterized by the accumulation of aberrant proteins in motor neurons of the brain and spinal cord.Patients with ALS develop skeletal muscle we...
关键词:PARALYSIS SCLEROSIS 
Mechanisms behind elevated serum levels of plasminogen activator inhibitor-1 in frontotemporal lobar degeneration
《Neural Regeneration Research》2025年第8期2317-2318,共2页Francesco Angelucci Jakub Hort 
funded by the project National Institute for Neurological Research(Programme EXCELES,ID Project No.LX22NPO5107);TEAMING:857560(EU);CZ.02.1.01/0.0/0.0/17_043/0009632(CZ)(to FA and JH)。
Frontotemporal lobar degeneration(FTLD)is a form of progressive dementia characterized by degeneration of the frontal and temporal lobes of the brain.This pathology involves a series of cognitive,behavioral,and neurol...
关键词:DEGENERATION ELEVATED PATHOLOGY 
NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation
《Neural Regeneration Research》2025年第7期2038-2052,共15页Zhihao Lin Changzhou Ying Xiaoli Si Naijia Xue Yi Liu Ran Zheng Ying Chen Jiali Pu Baorong Zhang 
supported by the National Natural Science Foundation of China,Nos.82271444(to JP),82271268(to BZ),and 82001346(to YL);the National Key Research and Development Program of China,No.2022YFE0210100(to BZ)。
Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra compacta.Ferroptosis,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,p...
关键词:dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) NEUROINFLAMMATION Parkinson's disease 
Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications
《Neural Regeneration Research》2025年第5期1324-1335,共12页Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh 
supported by the Department of Veterans Affairs(VA Merit Award BX004256)(to AMA);Emory Department of Neurosurgery Catalyst Grant;Emory Medical Care Foundation Grant(to AMA and JG)。
Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery...
关键词:COMPLEMENT NEUROINFLAMMATION NEUROPLASTICITY regeneration spinal cord injury targeted therapy 
Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology
《Neural Regeneration Research》2025年第5期1407-1408,共2页Daniel Adam Felix Langerscheidt Hans Zempel 
TAU is a neuronal microtubule-associated protein preferentially located in axons.In a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosph...
关键词:ALZHEIMER TAU diseases 
Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly
《Neural Regeneration Research》2025年第5期1409-1410,共2页Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela 
Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic plasticity.AD has progressively been recognized as syna ptopathy and ...
关键词:ALZHEIMER PATHOLOGY 
Gastric cancer in patients with Helicobacter pylori-negative autoimmune gastritis
《World Journal of Gastrointestinal Oncology》2025年第4期8-16,共9页Hiroshi Kishikawa Jiro Nishida 
Although Helicobacter pylori(H.pylori)is implicated in the development of most cases of gastric cancer with autoimmune gastritis,cases of gastric cancer have been reported in patients testing negative for H.pylori.Her...
关键词:Helicobacter pylori Autoimmune gastritis Gastric cancer Gastrointestinal pathology GASTRIN Atrophic gastritis ENDOSCOPY 
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