Navigating the pathways:TAR-DNA-binding-protein-43 aggregation,axonal transport,and local synthesis in amyotrophic lateral sclerosis pathology  

作　　者：Ori Bar Avi Eran Perlson 

机构地区：[1]Department of Physiology and Pharmacology,Faculty of Medical&Health Science,Tel-Aviv University,Tel-Aviv,Israel [2]Sagol School of Neuroscience,Tel-Aviv University,Tel-Aviv,Israel

出　　处：《Neural Regeneration Research》2025年第10期2921-2922,共2页中国神经再生研究（英文版）

摘　　要：Neurons are highly polarized cells with axons reaching over a meter long in adult humans.To survive and maintain their proper function,neurons depend on specific mechanisms that regulate spatiotemporal signaling and metabolic events,which need to be carried out at the right place,time,and intensity.Such mechanisms include axonal transport,local synthesis,and liquid-liquid phase separations.Alterations and malfunctions in these processes are correlated to neurodegenerative diseases such as amyotrophic lateral sclerosis(ALS).

关 键 词：SYNTHESIS LOCAL AGGREGATION 

分 类 号：R744.8[医药卫生—神经病学与精神病学]