Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology  

作　　者：Daniel Adam Felix Langerscheidt Hans Zempel 

机构地区：[1]Institute of Human Genetics,University Hospital Cologne,Cologne,Germany [2]Center for Molecular Medicine Cologne(CMMC),University of Cologne,Cologne,Germany

出　　处：《Neural Regeneration Research》2025年第5期1407-1408,共2页中国神经再生研究（英文版）

摘　　要：TAU is a neuronal microtubule-associated protein preferentially located in axons.In a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关 键 词：ALZHEIMER TAU diseases 

分 类 号：R749.16[医药卫生—神经病学与精神病学]