Syndecans in Alzheimer's disease:pathogenetic mechanisms and potential therapeutic targets  

作　　者：Carmela Rita Balistreri Roberto Monastero 

机构地区：[1]Cellular,Molecular and Clinical Pathological Laboratory,Department of Biomedicine,Neuroscience and Advanced Diagnostics(Bi.N.D.),University of Palermo,Palermo,Italy [2]Memory and Parkinson’s disease Center,Policlinico“Paolo Giaccone”,Palermo,Department of Biomedicine,Neuroscience and Advanced Diagnostics(Bi.N.D.),University of Palermo,Via La Loggia 1,Palermo,Italy

出　　处：《Neural Regeneration Research》2025年第9期2594-2595,共2页中国神经再生研究（英文版）

基　　金：supported by grants from the Next Generation EU-MUR D.M.737/2021-Project PSEBPEHRD-CUP B79J21038330001(to CRB)。

摘　　要：With increasing age,humans become more susceptible to the onset of neurodegenerative diseases(NDs),and among these,Alzheimer's disease(AD)is the most frequent(Nicoletti et al.,2023).NDs are primarily characterized by neuronal loss and atrophy,but also by lesions involving the cerebral and/or cardiovascular system(Balistreri,2021).Lesions such as macroinfa rcts,microinfarcts,hemorrhages,white matter lesions,atherosclerosis,and arteriolosclerosis have also been significantly described in the preclinical stages of cognitive impairment characterizing NDs(Mariani et al.,2007).

关 键 词：ALZHEIMER CARDIOVASCULAR 

分 类 号：R749.16[医药卫生—神经病学与精神病学]