Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: the risk of senescent drift induction in secretome-based therapeutics  

作　　者：Anna Smirnova Elena Yatsenko Denis Baranovskii Ilya Klabukov 

机构地区：[1]National Medical Research Radiological Center,Obninsk,249036,Russia [2]Obninsk Institute for Nuclear Power Engineering,National Research Nuclear University MEPhI,Obninsk,249031,Russia

出　　处：《Military Medical Research》2024年第5期792-793,共2页军事医学研究（英文版）

摘　　要：Regulatory changes in senescent cells could potentially affect the composition of extracellular vehicles(EVs),specifically altering their size and cargo.As a result,the released senescent EVs contain an unpredictable cocktail of growth factors and cytokines.These biomolecules have dual effects,potentially guiding the induction of senescence in affected cells and promoting an inflammation-related“domino effect”within the cellular environment,ultimately leading to tissue inflammaging.

关 键 词：Cell therapy INFLAMMAGING SECRETOME SENESCENCE 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]