CCL2-CCR2 axis in cardiovascular disease:research advances and challenges  

心血管疾病中的CCL2-CCR2轴:研究进展和挑战

作　　者：Yang Yang Jiayan Li Jiayou Tang Bo Wang Jing Wang Xuezeng Xu Wangrui Lei Ying Cheng Liwen Liu 杨阳;李佳妍;唐嘉佑;王博;王静;徐学增;雷王蕊;陈颖;刘丽雯

机构地区：[1]Xijing Hypertrophic Cardiomyopathy Center,Department of Ultrasound,Xijing Hospital,The Airforce Military Medical University,Xi’an 710032,China [2]Xi’an Key Laboratory of Innovative Drug Research for Heart Failure,Faculty of Life Sciences and Medicine,Northwest University,Xi’an 710069,China [3]Department of Cardiovascular Surgery,Xijing Hospital,The Fourth Military Medical University,Xi’an 710032,China

出　　处：《Science Bulletin》2025年第6期820-824,共5页科学通报(英文版)

基　　金：supported by the National Natural Science Foundation of China(82270526,82070422,82200330,82071932,82371974,and 82272009);Key Medical Research Projects in Xi’an City(24YXYJ0010);Shaanxi Province Traditional Chinese Medicine Research and Innovation Talent Project(TZKN-CXRC-06);Research Plan Project of Shaanxi Institute of Basic Science(22JHQ053);Qinchuangyuan Traditional Chinese Medicine Innovation Research and Development Transformation Project(2022-QCYZH-036).

摘　　要：C-C motif chemokine ligand 2(CCL2)is a member of the chemokine family and is also known as monocyte chemoattractant protein-1.It is a crucial factor for regulating the migration and infiltration of various immune cells,such as monocytes.

关 键 词：monocyte chemoattractant protein chemokine family cardiovascular disease CCL immune cells migration infiltration c chemokine ligand MONOCYTES 

分 类 号：R54[医药卫生—心血管疾病]