INTRATUMORAL

作品数：49被引量：123H指数：6
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相关领域：医药卫生生物学更多>>
相关作者：金时代束永前卢凯华张智弘冯锋更多>>
相关机构：南方医科大学南方医院深圳市人民医院江苏省人民医院华中科技大学更多>>
相关期刊：《Hepatobiliary & Pancreatic Diseases International》《Chinese Medical Journal》《Chemical Research in Chinese Universities》《Chinese Journal of Cancer Research》更多>>
相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划高等学校学科创新引智计划更多>>
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Orally Administrated Hydrogel Harnessing Intratumoral Microbiome and Microbiota-Related Immune Responses for Potentiated Colorectal Cancer Treatment
《Research》2025年第1期68-88,共21页Lei Li Shouhua He Boyi Liao Manchun Wang Huimin Lin Ben Hu Xinyue Lan Zhilin Shu Chao Zhang Meng Yu Zhaowei Zou 
supported by the Natural Science Foundation of Guangdong Province(2023A1515030291);Science and Technology Program of Guangzhou(202201011130280065);Dongguan Science and Technology of Social Development Program(20211800905282).
The intestinal and intratumoral microbiota are closely associated with tumor progression and response to antitumor treatments.The antibacterial or tumor microenvironment(TME)-modulating approaches have been shown to m...
关键词：intratumoral microbiota antitumor treatmentsthe intestinal microbiota normalizing microbial environment colorectal cancer treatment HYDROGEL microbiota related immune responses 
Beyond the tumor region:Peritumoral radiomics enhances prognostic accuracy in locally advanced rectal cancer
《World Journal of Gastroenterology》2025年第8期49-65,共17页Zhi-Ying Liang Mao-Li Yu Hui Yang Hao-Jiang Li Hui Xie Chun-Yan Cui Wei-Jing Zhang Chao Luo Pei-Qiang Cai Xiao-Feng Lin Kun-Feng Liu Lang Xiong Li-Zhi Liu Bi-Yun Chen 
BACKGROUND The peritumoral region possesses attributes that promote cancer growth and progression.However,the potential prognostic biomarkers in this region remain relatively underexplored in radiomics.AIM To investig...
关键词：Rectal cancer Peritumoral radiomics Intratumoral radiomics Prognosis analysis Variable importance analysis Tumor microenvironment 
Locally producing antibacterial peptide to deplete intratumoral pathogen for preventing metastatic breast cancer
《Acta Pharmaceutica Sinica B》2025年第2期1084-1097,共14页Shizhen Geng Tingting Xiang Yaru Shi Mengnian Cao Danyu Wang Jing Wang Xinling Li Haiwei Song Zhenzhong Zhang Jinjin Shi Junjie Liu Airong Li Ke Sun 
supported by the National Natural Science Foundation of China(82172762,21904119,and 82073395);Science and technology innovation talents support project of Henan Province(23HASTIT041);Henan Science Fund for Outstanding Young Scholars(232300421051,China).
Metastatic dissemination is the major cause of death from breast-cancer(BC).Fusobacterium nucleatum(F.n)is widely enriched in BC and has recently been identified as one of the high-risk factors for promoting BC metast...
关键词：Intratumoral pathogen METASTASIS Antibacterial peptide OPTOGENETICS Breast cancer Fusobacterium nucleatum Cancer-associated fibroblast Mild heat 
A mechanistic study of radiotherapy on intratumoral NK cell infiltration augmentation by regulating the EZH2/CXCL10 pathway in hepatocellular carcinoma cells
《China Medical Abstracts(Internal Medicine)》2024年第4期223-223,共1页ZHAO Xiaofang 
Objective To investigate the effect and associated mechanism of tumor tissue-infiltrating NK cells after receiving radiotherapy for hepatoellular carcinoma(HCC).Methods A HCC tumor-bearing mouse model was constructed ...
关键词：CXCL10 EZH2 carcinoma 
Intratumoral lactic acid neutralization strategy for boosting chemoimmunotherapy using liposomal sodium bicarbonate
《Science Bulletin》2024年第24期3936-3948,共13页Taoxing Peng Xinyue Shao Wenqin Song Weihua Xu Wei Xiong Yihao He Yang Ding Yongzhuo Huang 
the National Key Research and Development Program of China(2021YFC400600,2022YFE0203600);the National Natural Science Foundation of China(81925035 and 82341232);the Future Network(083GJHZ2023012FN);Grand Challenges(083GJHZ2023021GC)of the International Partnership Program of the Chinese Academyof Sciences,CAS President’s International Fellowship Initiative(2024VBB0004);High-level Innovative Research Institute(2021B0909050003)from Department of Science;Technology of Guangdong Province;Zhongshan Municipal Bureau of Science and Technology(LJ2021001 and CXTD2022011).
Glycolysis-related lactic acid overproduction creates an“ion-trapping”barrier and immunosuppressive tumor microenvironment that compromise effective intratumoral drug delivery and therapy.Therefore,normalization of ...
关键词：Sodium bicarbonate Lactic acid neutralization Tumor microenvironment normalization CHEMOIMMUNOTHERAPY PD-1 antibody Ion-trapping barrier 
Tumor-related fungi and crosstalk with gut fungi in the tumor microenvironment被引量：1
《Cancer Biology & Medicine》2024年第11期977-994,共18页Yue Wang Yiwen Wang Yuhang Zhou Yun Feng Tao Sun Junnan Xu 
supported by the National Natural Science Foundation of China(Grant No.82373113 to XJ);Shenyang Public Health R&D Special Project(Grant No.22-321-31-04 to ST);Liaoning Revitalization Talents Program(Grant No.XLYC1907160 to XJ);Beijing Medical Award Foundation(Grant Nos.YXJL-2020-0941-0752 to ST and CORP239-N27 to CH);Wu Jieping Medical Foundation(Grant Nos.320.6750.2020-12-21 and 320.6750.2020-6-30 to ST);the Fundamental Research Funds for the Central Universities(Grant Nos.202229 to ST and 202230 to XJ)。
Most studies on the human gut microbiome have focused on the bacterial fraction rather than fungal biomics,which as resulted in an incomplete understanding of the fungal microbiome.Recent advances in microbiota detect...
关键词：Gut microbiota FUNGI INTRATUMORAL CANCER cancer treatment responsiveness Candida albicans 
Beyond the Gut:The intratumoral microbiome’s influence on tumorigenesis and treatment response
《Cancer Communications》2024年第10期1130-1167,共38页Hao Zhang Li Fu Xinwen Leiliang Chunrun Qu Wantao Wu Rong Wen Ning Huang Qiuguang He Quan Cheng Guodong Liu Yuan Cheng 
National Natural Science Foundation of China,Grant/Award Numbers:82372943,82303610;Hunan Provincial Natural Science Foundation of China,Grant/Award Number:2022JJ20095;Hunan Youth Science and Technology Talent Project,Grant/Award Number:2023RC3074;China Postdoctoral Science Foundation,Grant/Award Number:2023MD734131;Chongqing Postdoctoral Science Foundation,Grant/Award Number:CSTB2023NSCQBHX0002;Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University;Chongqing Postdoctoral Research Special Funding Project,Grant/Award Number:2023CQBSHTB3095。
The intratumoral microbiome(TM)refers to the microorganisms in the tumor tissues,including bacteria,fungi,viruses,and so on,and is distinct from the gut microbiome and circulating microbiota.TM is strongly associated ...
关键词：analysis methods IMMUNOTHERAPY intratumoral microbiome treatment application tumorpromotive and tumor-suppressive mechanisms 
Legumain-triggered aggregable gold nanoparticles for enhanced intratumoral retention被引量：1
《Chinese Chemical Letters》2024年第7期388-393,共6页Zhi Li Wenpei Li Shaoping Jiang Chuan Hu Yuanyu Huang Maxim Shevtsov Huile Gao Shaobo Ruan 
supported by the Beijing Natural Science Foundation(No.L222128);Beijing Institute of Technology Research Fund Program for Young Scholars(No.XSQD-202121010);National Natural Science Foundation of China(No.81961138009)。
Insufficient intratumoral retention of nanomedicines remains the major challenge for broad implementation in clinical sets.Herein,we proposed a legumain-triggered aggregable gold nanoparticle(GNP)delivery platform(GNP...
关键词：LEGUMAIN Size-tunable Enhanced retention Stimulus-responsive NANOMEDICINE 
Preoperatively predicting vessels encapsulating tumor clusters in hepatocellular carcinoma:Machine learning model based on contrast-enhanced computed tomography
《World Journal of Gastrointestinal Oncology》2024年第3期857-874,共18页Chao Zhang Hai Zhong Fang Zhao Zhen-Yu Ma Zheng-Jun Dai Guo-Dong Pang 
The study was reviewed and approved by the Second Hospital of Shandong University Institutional Review Board,IRB No.KYLL-2023LW044.
BACKGROUND Recently,vessels encapsulating tumor clusters(VETC)was considered as a distinct pattern of tumor vascularization which can primarily facilitate the entry of the whole tumor cluster into the bloodstream in a...
关键词：Hepatocellular carcinoma Vessels encapsulating tumor clusters Intratumoral and peritumoral regions Radiomics features Nomog 
Intratumoral CD103^(+)CD8^(+)T cells predict response to neoadjuvant chemoimmunotherapy in advanced head and neck squamous cell carcinoma被引量：2
《Cancer Communications》2023年第10期1143-1163,共21页Siqi Ren Tianjun Lan Fan Wu Suling Chen Xue Jiang Chuying Huo Zitian Li Shule Xie Donghui Wu Ruixin Wang Yanyan Li Lin Qiu Guoxin Huang Shurui Li Xiaojuan Wang Meifeng Cen Tingting Cai Zhaoyu Lin Jinsong Li Bowen Li 
supported by the National Natural Science Foundation of China(82272788,82072990,81903045,and 82072988);China Postdoctoral Science Foundation(2021M703692);Department of Health of Guangdong Province Science Foundation(A2022165 and A2021142);Guangzhou Municipal Science and Technology Project(202201011479);Guangdong Science and Technology Development Fund(2019A1515011867 and 2020A1515010405).
Background Immune cell heterogenicity is known to determine the therapeutic response to cancer progression.Neoadjuvant chemoimmunotherapy(NACI)has shown clinical benefits in some patients with advanced head and neck s...
关键词：CD103 CD8 head and neck squamous cell carcinoma neoadjuvant chemoimmunotherapy predictive marker tumor-infiltrating lymphocyte 
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