Beyond the Gut:The intratumoral microbiome’s influence on tumorigenesis and treatment response  

作　　者：Hao Zhang Li Fu Xinwen Leiliang Chunrun Qu Wantao Wu Rong Wen Ning Huang Qiuguang He Quan Cheng Guodong Liu Yuan Cheng 

机构地区：[1]Department of Neurosurgery,The Second Affiliated Hospital,Chongqing Medical University,Chongqing,P.R.China [2]Department of Gastroenterology,The Second Affiliated Hospital,Chongqing Medical University,Chongqing,P.R.China [3]Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha,Hunan,P.R.China [4]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan,P.R.China [5]Department of Oncology,Xiangya Hospital,Central South University,Changsha,Hunan,P.R.China

出　　处：《Cancer Communications》2024年第10期1130-1167,共38页癌症通讯（英文）

基　　金：National Natural Science Foundation of China,Grant/Award Numbers:82372943,82303610;Hunan Provincial Natural Science Foundation of China,Grant/Award Number:2022JJ20095;Hunan Youth Science and Technology Talent Project,Grant/Award Number:2023RC3074;China Postdoctoral Science Foundation,Grant/Award Number:2023MD734131;Chongqing Postdoctoral Science Foundation,Grant/Award Number:CSTB2023NSCQBHX0002;Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University;Chongqing Postdoctoral Research Special Funding Project,Grant/Award Number:2023CQBSHTB3095。

摘　　要：The intratumoral microbiome(TM)refers to the microorganisms in the tumor tissues,including bacteria,fungi,viruses,and so on,and is distinct from the gut microbiome and circulating microbiota.TM is strongly associated with tumorigenesis,progression,metastasis,and response to therapy.This paper highlights the current status of TM.Tract sources,adjacent normal tissue,circulatory system,and concomitant tumor co-metastasis are the main origin of TM.The advanced techniques in TM analysis are comprehensively summarized.Besides,TMis involved in tumor progression through several mechanisms,including DNA damage,activation of oncogenic signaling pathways(phosphoinositide 3-kinase[PI3K],signal transducer and activator of transcription[STAT],WNT/β-catenin,and extracellular regulated protein kinases[ERK]),influence of cytokines and induce inflammatory responses,and interaction with the tumor microenvironment(anti-tumor immunity,pro-tumor immunity,and microbial-derived metabolites).Moreover,promising directions of TM in tumor therapy include immunotherapy,chemotherapy,radiotherapy,the application of probiotics/prebiotics/synbiotics,fecal microbiome transplantation,engineered microbiota,phage therapy,and oncolytic virus therapy.The inherent challenges of clinical application are also summarized.This review provides a comprehensive landscape for analyzing TM,especially the TM-related mechanisms and TM-based treatment in cancer.

关 键 词：analysis methods IMMUNOTHERAPY intratumoral microbiome treatment application tumorpromotive and tumor-suppressive mechanisms 

分 类 号：R73[医药卫生—肿瘤]