Spatiotemporal responsive hydrogel microspheres for the treatment of gastric cancer  

作　　者：Li Wang Lu Fan Anne M.Filppula Yu Wang Luoran Shang Hongbo Zhang 

机构地区：[1]Joint Centre of Translational Medicine,Wenzhou Key Laboratory of Interdiscipline and Translational Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China [2]Pharmaceutical Sciences Laboratory,Åbo Akademi University,Turku,Finland [3]Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,Zhejiang,China [4]Shanghai Xuhui Central Hospital,Zhongshan-Xuhui Hospital,the Shanghai Key Laboratory of Medical Epigenetics,the International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology),Institutes of Biomedical Sciences,Fudan University,Shanghai,China [5]Turku Bioscience Centre,University of Turku andÅbo Akademi University,Turku,Finland

出　　处：《Aggregate》2024年第5期445-453,共9页聚集体（英文）

基　　金：National Natural Science Foundation of China,Grant/Award Number:82372145;Research Fellow,Grant/Award Number:353146;Research Project,Grant/Award Number:347897;Solutions for Health Profile,Grant/Award Number:336355;InFLAMES Flagship,Grant/Award Number:337531;Finland China Food and Health International Pilot project funded by Finnish MInistry of Education and Culture。

摘　　要：The development of tumor drug microcarriers has attracted considerable interest due to their distinctive therapeutic performances.Current attempts tend to elab-orate on the micro/nano-structure design of the microcarriers to achieve multiple drug delivery and spatiotemporal responsive features.Here,the desired hydrogel microspheres are presented with spatiotemporal responsiveness for the treatment of gastric cancer.The microspheres are generated based on inverse opals,their skele-ton is fabricated by biofriendly hyaluronic acid methacrylate(HAMA)and gelatin methacrylate(GelMA),and is thenfilled with a phase-changing hydrogel composed offish gelatin and agarose.Besides,the incorporated black phosphorus quantum dots(BPQDs)within thefilling hydrogel endow the microspheres with outstanding pho-tothermal responsiveness.Two antitumor drugs,sorafenib(SOR)and doxorubicin(DOX),are loaded in the skeleton andfilling hydrogel,respectively.It is found that the drugs show different release profiles upon near-infrared(NIR)irradiation,which exerts distinct performances in a controlled manner.Through both in vitro and in vivo experiments,it is demonstrated that such microspheres can significantly reduce tumor cell viability and enhance the efficiency in treating gastric cancer,indicating a promising stratagem in thefield of drug delivery and tumor therapy.

关 键 词：combination therapy gastric cancer inverse opal MICROCARRIERS spatiotemporal responsiveness 

分 类 号：R730.5[医药卫生—肿瘤]