Utilizing dual-responsive iridium(Ⅲ) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy  

作　　者：Jinyu Guo Yandai Lin Shaohua He Yueqing Chen Fenglu Li Renjie Ruan Gaoxing Pan Hexin Nan Jibin Song Jin Zhang 

机构地区：[1]Qingyuan Innovation Laboratory,Quanzhou 362801,China [2]College of Chemical Engineering,Fuzhou University,Fuzhou 350108,China [3]MOE Key Laboratory for Analytical Science of Food Safety and Biology,State Key Laboratory of Photocatalysis on Energy and Environment,College of Chemistry,Fuzhou University,Fuzhou 350108,China [4]Department of Pediatric Surgery,Shengli Clinical Medical College of Fujian Medical University,Fuzhou 350001,China

出　　处：《Chinese Chemical Letters》2024年第9期296-302,共7页中国化学快报（英文版）

基　　金：supported by the National Key R&D Program of China(Nos.2022YFB3808000,2022YFB3808001);the Project for High-Level Talent Innovation and Entrepreneurship of Quanzhou(No.2022C016R);the Medical Innovation Project of Science and Technology Program of Fujian Provincial Health Commission(No.2021CXA006);the Key Program of Qingyuan Innovation Laboratory(No.00221002).

摘　　要：Stimuli-triggered release and alleviating resistance of iridium(Ⅲ)-based drugs at tumor sites remains challengeable for clinical hepatoma therapy.Herein,a doxorubicin@iridium-transferrin(DOX@Ir-TF)nanovesicle was synthesized by carboxylated-transferrin(TF)and doxorubicin-loaded amphiphilic iridium-amino with quaternary ammonium(QA)groups and disulfide bonds.The QA groups enhanced photophysical properties and broadened production capacity of photoinduced-reactive oxygen species(ROS),while the disulfide-bridged bonds regulated oxidative stress levels through reacting with glutathione(GSH);simultaneously,modification of TF improved recognition and endocytosis of the nanovesicle for tumor cells.Based on in-vitro results,a controlled-release behavior of DOX upon a dualresponsiveness of GSH and near-infrared ray(NIR)irradiation was presented,along with high-efficiency generation of ROS.After an intravenous injection,the nanovesicle was targeted at tumor sites,realizing TF-navigated photoacoustic imaging guidance and synergistic chemotherapy-photodynamic therapy under NIR/GSH stimulations.Overall,newly-synthesized DOX@Ir-TF nanovesicle provided a potential in subcutaneous hepatocellular carcinoma therapy due to integrations of targeting delivery,dual-stimuli responsive release,synergistic therapy strategy,and real-time monitoring.

关 键 词：Amphiphilic iridium complex Transferrin targeting NIR/GSH dual-responsiveness Photoacoustic imaging Synergistic tumor therapy 

分 类 号：R735.7[医药卫生—肿瘤] O641.4[医药卫生—临床医学]