CARBOXYLESTERASES

作品数：15被引量：44H指数：4
导出分析报告
相关领域：医药卫生农业科学更多>>
相关期刊：《Emerging Contaminants》《Advances in Entomology》《Journal of Biomedical Research》《Insect Science》更多>>
相关基金：国家自然科学基金湖北省自然科学基金中国博士后科学基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Inhibitory effect of active ingredients of Tripterygium wilfordii Hook.F.on human carboxylesterases
《中国药理学与毒理学杂志》2024年第9期652-660,共9页LIANG Jiahong GONG Jiamin DU Zuo 
川北医学院博士科研启动基金(CBY20-QD02);南充市市校科技战略合作专项资金项目(20SXQT0318)。
OBJECTIVE The inhibitory effect of active ingredients of Tripterygium wilfordii Hook.F.(TWHF)(celastrol,triptolide,triptonide,wilforlide A,wilforgine and wilforine)on human carboxylester⁃ase 1(CES1)and CES2 was detect...
关键词：Tripterygium wilfordii Hook.F. CELASTROL CARBOXYLESTERASES enzyme inhibition 
Gastric carboxylesterases of the edible crab Cancer pagurus (Crustacea, Decapoda) can hydrolyze biodegradable plastics
《Emerging Contaminants》2024年第1期80-89,共10页Lukas Miksch Lars Gutow Reinhard Saborowski 
This work was supported by the European Union's Horizon 2020 research and innovation program(grant agreement number 860407).
A promising strategy to counteract the progressing plastic pollution of the environment can involve the replacement of persistent plastics with biodegradable materials.Biodegradable polymers are enzymatically degradab...
关键词：Biodegradable plastics Microplastics Crustaceans Ingestion ENZYMES Enzymatic degradation 
Cisplatin increases carboxylesterases through increasing PXR mediated by the decrease of DEC1
《The Journal of Biomedical Research》2023年第6期431-447,共17页Minqin Xu Lihua Zhang Lan Lin Zhiyi Qiang Wei Liu Jian Yang 
The work was supported by the National Natural Science Foundation of China(Grant Nos.82073934 and 81872937)to J.Y.
cis-Diamminedichloroplatinum(CDDP)is widely used for the treatment of various solid cancers.Here we reported that CDDP increased the expression and enzymatic activities of carboxylesterase 1(CES1)and carboxylesterase ...
关键词：cis-diamminedichloroplatinum pregnane X receptor differentiated embryonic chondrocyte-expressed gene 1 carboxylesterase 1 carboxylesterase 2 IRINOTECAN 
Lysosome-targeting red fluorescent probe for broad carboxylesterases detection in breast cancer cells
《Chinese Chemical Letters》2022年第9期4229-4232,共4页Yanyan Sun Xiaonan Zhou Liyuan Sun Xiuxiu Zhao Yongrui He Ge Gao Weina Han Jin Zhou 
the financial support from the National Natural Science Foundation of China (No. 21705120);the Technology Support Project of Shandong Province Higher Educational Youth Innovation (No. 2019KJM008);the Natural Science Foundation of Shandong Province, China (No. ZR2017LB016);the Project of Shandong Province Higher Educational Science and Technology Program (No. J17KB074)
Available online The abnormal carboxylesterase(CES)expression is closely related to many diseases such as hyperlipidemia,atherosclerosis,obesity,liver cancer,type 2 diabetes mellitus and gastrointestinal stromal tumor...
关键词：Fluorescent probe CARBOXYLESTERASES Broad detection Breast cancerLysosome-targeting Red fluorescence 
The nucleoside antiviral prodrug remdesivir in treating COVID-19 and beyond with interspecies significance
《Animal Diseases》2022年第1期1-15,共15页Daisy Yan One Hyuk Ra Bingfang Yan 
supported by National Institutes of Health Grants R01 EB018748,R21 Al153031;University of Cincinnati Cancer Center(Yan,B).
Infectious pandemics result in hundreds and millions of deaths,notable examples of the Spanish Flu,the Black Death and smallpox.The current pandemic,caused by SARS-CoV-2(severe acute respiratory syndrome coronavirus 2...
关键词：Animal model CARBOXYLESTERASES COVID-19 CORONAVIRUS Drug-drug interactions interspecies difference Pandemic Remdesivir SARS-CoV-2 
Molecular and functional characterization of three novel carboxylesterases in the detoxification of permethrin in the mosquito, Culex quinquefasciatus被引量：1
《Insect Science》2022年第1期199-214,共16页Youhui Gong Ming Li Ting Li Nannan Liu 
The project described was supported by the following awards:AAES Hatch/Multistate Grants ALA08-045,ALA015-1-10026,ALA015-1-16009 to NL.
Carboxylesterases (CarEs) belong to a super family of multifunctional enzymes associated with the degradation of endogenous and exogenous compounds. Many insect CarEs are known to play important roles in catalyzing th...
关键词：CARBOXYLESTERASE Culex quinquefasciatus gene expression in vitro protein expression metabolism permethrin resistance 
Carboxylesterases mediated herb-drug interactions:a systematic review
《TMR Modern Herbal Medicine》2019年第1期25-35,共11页Dan-Dan Wang Yun-Qing Song Ya-Di Zhu Yi-Nan Wang Hai-Feng Li Guang-Bo Ge Ling Yang 
the National Key Research and Development Program of China(2017YFC1700200,2017YFC1702000);the National Scientific and Technological Major Projects of China(2017ZX09101004);the National Natural Science Foundation of China(81703604,81773687 and 81573501);Program of Shanghai Academic/Technology Research Leader(18XD1403600);Shuguang Program(No.18SG40);Shanghai Education Development Foundation and Shanghai Municipal Education Commission,Project funded by China Postdoctoral Science Foundation(2017M621520,and 2018T110406).
Esterases participate in the metabolism of^10%of the clinical drugs that contain ester or amide bonds,but the esterases mediated drug/herb-drug interactions(DDIs or HDIs)have not been reviewed in depth.Carboxylesteras...
关键词：Human carboxylesterases(CEs) HCE1 hCE2 herb-drug interactions Natural inhibitors 
Assay development for determination of DZ2002, a new reversible SAHH inhibitor, and its acid metabolite DZA in blood and application to rat pharmacokinetic study被引量：1
《Journal of Pharmaceutical Analysis》2019年第1期25-33,共9页Weiwei Jia Jing Li Feifei Du Yan Sun Fang Xu Fengqing Wang Olajide E.Olaleye Danghui Chen Wei Tang Jianping Zuo Chuan Li 
funded by grants from the National Science & Technology Major Project of China ‘Key New Drug Creation and Manufacturing Program’ (2017ZX09301012-006);the National Natural Science Foundation of China (81603380);the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA12050306)
Methyl(S)-4-(6-amino-9 H-purin-9-yl)-2-hydroxybutanoate(DZ2002) is a potent reversible inhibitor of S-adenosyl-L-homocysteine hydrolase(SAHH). Due to its ester structure, DZ2002 is rapidly hydrolyzed in rat blood to 4...
关键词：S-adenosyl-L-homocysteine HYDROLASE DZ2002 CARBOXYLESTERASES PHARMACOKINETICS 
Human carboxylesterases:a comprehensive review被引量：18
《Acta Pharmaceutica Sinica B》2018年第5期699-712,共14页Dandan Wang Liwei Zou Qiang Jin Jie Hou Guangbo Ge Ling Yang 
supported by the National Key Research and Development Program of China (2016YFC1303900,2017YFC1700200,2017YFC1702000);the National Scientific and Technological Major Projects of China (2017ZX09101004);the National Natural Science Foundation of China (81703604,81773687,21602219,81573501 and 81473181);Program of Shanghai Academic/Technology Research Leader (18XD1403600);the Innovative Entrepreneurship Program of High-level Talents in Dalian (2016RQ025)
Mammalian carboxylesterases(CEs) are key enzymes from the serine hydrolase superfamily.In the human body, two predominant carboxylesterases(CES1 and CES2) have been identified and extensively studied over the past dec...
关键词：Human CARBOXYLESTERASES CES1 CES2 Substrate PREFERENCE Inhibitor spectra INDUCER 
Carboxylesterases in lipid metabolism： From mouse to human被引量：12
《Protein & Cell》2018年第2期178-195,共18页Jihong Lian Randal Nelson Richard Lehner 
Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of car- boxylesterases in lipid metabolism and energy home- ostasis in vivo ha...
关键词：CARBOXYLESTERASE LIPASE lipid lipoprotein iver ADIPOSE INTESTINE 
全选清除导出
共2页<12>
检索报告 对象比较 聚类工具 使用帮助 返回顶部