Carboxylesterases in lipid metabolism： From mouse to human  

作　　者：Jihong Lian Randal Nelson Richard Lehner 

机构地区：[1]Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada [2]Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada [3]Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada

出　　处：《Protein & Cell》2018年第2期178-195,共18页蛋白质与细胞（英文版）

摘　　要：Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of car- boxylesterases in lipid metabolism and energy home- ostasis in vivo have been demonstrated by genetic manipulations and chemical inhibition in mice, and in vitro through （over）expression, knockdown of expression, and chemical inhibition in a variety of cells. Recent research advances have revealed the relevance of carboxylesterases to metabolic diseases such as obesity and fatty liver disease, suggesting these enzymes might be potential targets for treatment of metabolic disorders. In order to translate pre-clinical studies in cellular and mouse models to humans, dif- ferences and similarities of carboxylesterases between mice and human need to be elucidated. This review presents and discusses the research progress in structure and function of mouse and human car- boxylesterases, and the role of these enzymes in lipid metabolism and metabolic disorders.Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of car- boxylesterases in lipid metabolism and energy home- ostasis in vivo have been demonstrated by genetic manipulations and chemical inhibition in mice, and in vitro through （over）expression, knockdown of expression, and chemical inhibition in a variety of cells. Recent research advances have revealed the relevance of carboxylesterases to metabolic diseases such as obesity and fatty liver disease, suggesting these enzymes might be potential targets for treatment of metabolic disorders. In order to translate pre-clinical studies in cellular and mouse models to humans, dif- ferences and similarities of carboxylesterases between mice and human need to be elucidated. This review presents and discusses the research progress in structure and function of mouse and human car- boxylesterases, and the role of these enzymes in lipid metabolism and metabolic disorders.

关 键 词：CARBOXYLESTERASE LIPASE lipid lipoprotein iver ADIPOSE INTESTINE 

分 类 号：TQ658[化学工程—精细化工] TS974.1[轻工技术与工程]